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Dabrafenib and Ipi
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Dabrafenib and Ipi

› Forums › General Melanoma Community › Dabrafenib and Ipi

  • Post
    • August 12, 2013 at 5:47 pm
    DeniseK
    Participant

      Wow, I must really be breaking ground here.  I went to look up what the side effects could be from combining Dabrafenib and Ipi and there are no results.  There is a clinical trial being conducted with this combo but no results posted because it's a fairly new trial.  I can tell you that I don't feel bad at all, matter of fact I feel good, no side effects to speak of and the tumor on my arm is getting smaller.  I did get sunburned on Saturday pretty bad but seemed to have just about healed this morning.  

      Wow, I must really be breaking ground here.  I went to look up what the side effects could be from combining Dabrafenib and Ipi and there are no results.  There is a clinical trial being conducted with this combo but no results posted because it's a fairly new trial.  I can tell you that I don't feel bad at all, matter of fact I feel good, no side effects to speak of and the tumor on my arm is getting smaller.  I did get sunburned on Saturday pretty bad but seemed to have just about healed this morning.  

      Is anyone else taking Dabrafenib instead of Z and did you take Z first?  Just wondering if you can tell the difference. 

      Today is a good day!  

      All my best to you all

      Denise

    Viewing 11 reply threads
    • Replies
        • August 13, 2013 at 1:40 am
        POW
        Participant

          Yes, Denise, you really are blazing the trail here. Actually, based on clinical trial results I always thought that I would rather take Dabrafenib than Zelboraf (assuming I had to take either one). But Zelboraf completed their trials first, got FDA approval first, and got all the publicity first. Dabrafenif is going to be playing "catch up" for quite a while yet. 

          I am delighted that you are getting a good response and that your side effects are minimal. Please do update this thread periodically so that future melanoma patients will get a "hit" when they do a search! And if you hear any preliminary reports about the clinical trial, tell us about those, too. I am very hopeful that this combination will work for a lot of people. 

          • August 13, 2013 at 1:40 am
          POW
          Participant

            Yes, Denise, you really are blazing the trail here. Actually, based on clinical trial results I always thought that I would rather take Dabrafenib than Zelboraf (assuming I had to take either one). But Zelboraf completed their trials first, got FDA approval first, and got all the publicity first. Dabrafenif is going to be playing "catch up" for quite a while yet. 

            I am delighted that you are getting a good response and that your side effects are minimal. Please do update this thread periodically so that future melanoma patients will get a "hit" when they do a search! And if you hear any preliminary reports about the clinical trial, tell us about those, too. I am very hopeful that this combination will work for a lot of people. 

            • August 13, 2013 at 1:40 am
            POW
            Participant

              Yes, Denise, you really are blazing the trail here. Actually, based on clinical trial results I always thought that I would rather take Dabrafenib than Zelboraf (assuming I had to take either one). But Zelboraf completed their trials first, got FDA approval first, and got all the publicity first. Dabrafenif is going to be playing "catch up" for quite a while yet. 

              I am delighted that you are getting a good response and that your side effects are minimal. Please do update this thread periodically so that future melanoma patients will get a "hit" when they do a search! And if you hear any preliminary reports about the clinical trial, tell us about those, too. I am very hopeful that this combination will work for a lot of people. 

              • August 13, 2013 at 7:48 am
              GAngel
              Participant

                Hi Denise, my husband took Zel first for a couple of months and is now on the Dabrafenib/MEK combo and he wanted me to post and let you know that he can definitely tell the difference in that the side effects are fewer and less severe and he feels MUCH better than he did when on Zel. We are praying for you and hoping that your current treatment plan works for you. We truly think that in order for healing to take place that one has to believe that it is possible!

                May you never stop believing!

                Gina 

                • August 13, 2013 at 7:48 am
                GAngel
                Participant

                  Hi Denise, my husband took Zel first for a couple of months and is now on the Dabrafenib/MEK combo and he wanted me to post and let you know that he can definitely tell the difference in that the side effects are fewer and less severe and he feels MUCH better than he did when on Zel. We are praying for you and hoping that your current treatment plan works for you. We truly think that in order for healing to take place that one has to believe that it is possible!

                  May you never stop believing!

                  Gina 

                  • August 13, 2013 at 7:48 am
                  GAngel
                  Participant

                    Hi Denise, my husband took Zel first for a couple of months and is now on the Dabrafenib/MEK combo and he wanted me to post and let you know that he can definitely tell the difference in that the side effects are fewer and less severe and he feels MUCH better than he did when on Zel. We are praying for you and hoping that your current treatment plan works for you. We truly think that in order for healing to take place that one has to believe that it is possible!

                    May you never stop believing!

                    Gina 

                    • August 13, 2013 at 11:52 am
                    Tina D
                    Participant

                      Hi Denise… No answers for you, but I am sure glad to hear that you are feeling well 🙂

                      And, thrilled to hear that your SQ is shrinking!!

                      Tina

                      • August 13, 2013 at 11:52 am
                      Tina D
                      Participant

                        Hi Denise… No answers for you, but I am sure glad to hear that you are feeling well 🙂

                        And, thrilled to hear that your SQ is shrinking!!

                        Tina

                        • August 13, 2013 at 11:52 am
                        Tina D
                        Participant

                          Hi Denise… No answers for you, but I am sure glad to hear that you are feeling well 🙂

                          And, thrilled to hear that your SQ is shrinking!!

                          Tina

                          • August 14, 2013 at 5:31 pm
                          DeniseK
                          Participant

                            There is definately a difference in the side effects being less, which is great news for those who cannot tolerate the Z.  Not only that the dabrafenib is supposed to break the brain barrier so it seems to be the better choice drug to take for BRAF patients.  

                            • August 14, 2013 at 5:31 pm
                            DeniseK
                            Participant

                              There is definately a difference in the side effects being less, which is great news for those who cannot tolerate the Z.  Not only that the dabrafenib is supposed to break the brain barrier so it seems to be the better choice drug to take for BRAF patients.  

                              • August 14, 2013 at 5:31 pm
                              DeniseK
                              Participant

                                There is definately a difference in the side effects being less, which is great news for those who cannot tolerate the Z.  Not only that the dabrafenib is supposed to break the brain barrier so it seems to be the better choice drug to take for BRAF patients.  

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