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Chemo after IPI
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Chemo after IPI

› Forums › General Melanoma Community › Chemo after IPI

  • Post
    • May 12, 2013 at 7:53 am
    Sandy11
    Participant

      Any recent experience with Chemo?  My husband completed IPI treatments in December.  IPI was awesome against the lung mets, but hasn't touched other tumors.  He also is among the not so lucky 2% that came away with Adrenal gland issues.  (Currently controlled with hydrocortisone)  He is not symptomatic and no mets in vital organs…

      Any recent experience with Chemo?  My husband completed IPI treatments in December.  IPI was awesome against the lung mets, but hasn't touched other tumors.  He also is among the not so lucky 2% that came away with Adrenal gland issues.  (Currently controlled with hydrocortisone)  He is not symptomatic and no mets in vital organs… that's the good news and he's still positive and fighting the fight.  He ws negative for the BRAF gene, so the doc says the next treatment option would be chemo.  We know that doesn't have the best track record against melanoma, but anyone have experience to share?  Nothing happening right now as my husband is feeling pretty well and plans on enjoying the summer. 

    Viewing 11 reply threads
    • Replies
        • May 12, 2013 at 10:42 am
        Amanda
        Participant

          Is he eligible for a Pd-1 trial?  My boyfriend did yervoy and achieved stable disease, but no shrinkage for about 6 months, then progressed.  Then started an Anti-Pd1 trial february 1st, all this tumors have shrunk dramatically, and are still shrinking slowly now.  Only side effects were some joint pain in his knees.  

          I'm sure others will chime in with opinoins as well.  Feel free to ask me any questions and i'd be glad to ask to the best of my knowledge and experience..

          • May 12, 2013 at 10:42 am
          Amanda
          Participant

            Is he eligible for a Pd-1 trial?  My boyfriend did yervoy and achieved stable disease, but no shrinkage for about 6 months, then progressed.  Then started an Anti-Pd1 trial february 1st, all this tumors have shrunk dramatically, and are still shrinking slowly now.  Only side effects were some joint pain in his knees.  

            I'm sure others will chime in with opinoins as well.  Feel free to ask me any questions and i'd be glad to ask to the best of my knowledge and experience..

            • May 12, 2013 at 10:42 am
            Amanda
            Participant

              Is he eligible for a Pd-1 trial?  My boyfriend did yervoy and achieved stable disease, but no shrinkage for about 6 months, then progressed.  Then started an Anti-Pd1 trial february 1st, all this tumors have shrunk dramatically, and are still shrinking slowly now.  Only side effects were some joint pain in his knees.  

              I'm sure others will chime in with opinoins as well.  Feel free to ask me any questions and i'd be glad to ask to the best of my knowledge and experience..

              • May 13, 2013 at 2:13 am
              awillett1991
              Participant
                I would definitely be aggressive in researching an anti PD1 trial. There are some slots around, and supposedly more coming soon. I did biochemo, it did not work. Chemo is not a cure for melanoma and often makes you feel terrible and leaves a lot of damage in its wake. Better to research and get in a trial while he’s feeling good, instead of waiting until you’re desperate. There are a lot of requirements and timing issues involved.
                  • May 13, 2013 at 4:33 am
                  Sandy11
                  Participant

                    thanks to all for the thoughts on anti PD1.. will definitely look into it. I don't know yet if his adrenal system shut down will put him out of the running for the trial. Will be seeing the doctor later this month. My husband's doc is very open to trials and the latest treatments available so no concerns there. What type of treatment is this? i.e. pill, infusion.. it appears to hold less side effects than ipi.

                    • May 14, 2013 at 9:27 am
                    Amanda
                    Participant

                      Yes, Pd-1 has shown to have less side effects that Yervoy, and it is administered as an infusion in the vein, just like yervoy..but for the Pd-1 (at least for us) the infusion itself is about a 30 minute infusion, as apposed to the about an hour and a half infusion we had on the Yervoy.  

                      • May 14, 2013 at 9:27 am
                      Amanda
                      Participant

                        Yes, Pd-1 has shown to have less side effects that Yervoy, and it is administered as an infusion in the vein, just like yervoy..but for the Pd-1 (at least for us) the infusion itself is about a 30 minute infusion, as apposed to the about an hour and a half infusion we had on the Yervoy.  

                        • May 14, 2013 at 9:27 am
                        Amanda
                        Participant

                          Yes, Pd-1 has shown to have less side effects that Yervoy, and it is administered as an infusion in the vein, just like yervoy..but for the Pd-1 (at least for us) the infusion itself is about a 30 minute infusion, as apposed to the about an hour and a half infusion we had on the Yervoy.  

                          • May 13, 2013 at 4:33 am
                          Sandy11
                          Participant

                            thanks to all for the thoughts on anti PD1.. will definitely look into it. I don't know yet if his adrenal system shut down will put him out of the running for the trial. Will be seeing the doctor later this month. My husband's doc is very open to trials and the latest treatments available so no concerns there. What type of treatment is this? i.e. pill, infusion.. it appears to hold less side effects than ipi.

                            • May 13, 2013 at 4:33 am
                            Sandy11
                            Participant

                              thanks to all for the thoughts on anti PD1.. will definitely look into it. I don't know yet if his adrenal system shut down will put him out of the running for the trial. Will be seeing the doctor later this month. My husband's doc is very open to trials and the latest treatments available so no concerns there. What type of treatment is this? i.e. pill, infusion.. it appears to hold less side effects than ipi.

                            • May 13, 2013 at 2:13 am
                            awillett1991
                            Participant
                              I would definitely be aggressive in researching an anti PD1 trial. There are some slots around, and supposedly more coming soon. I did biochemo, it did not work. Chemo is not a cure for melanoma and often makes you feel terrible and leaves a lot of damage in its wake. Better to research and get in a trial while he’s feeling good, instead of waiting until you’re desperate. There are a lot of requirements and timing issues involved.
                              • May 13, 2013 at 2:13 am
                              awillett1991
                              Participant
                                I would definitely be aggressive in researching an anti PD1 trial. There are some slots around, and supposedly more coming soon. I did biochemo, it did not work. Chemo is not a cure for melanoma and often makes you feel terrible and leaves a lot of damage in its wake. Better to research and get in a trial while he’s feeling good, instead of waiting until you’re desperate. There are a lot of requirements and timing issues involved.
                                • May 13, 2013 at 5:13 am
                                JerryfromFauq
                                Participant

                                  i AGREE THAT THE pd-1 tRIALS LOOK LIKE BOTH THE EASIEST AND MOST LIKELY SUCCESFUL TREATMENTS TO GO TO,

                                  I will also point out that Ipi the IL-2 has shown succes in some cases.  

                                  An additional point to remember is that after either Ipi or IL-2 there is a greater chance that older Chemo treatments may be more beneficial then when used as a stand-a-lone chemo.

                                  • May 13, 2013 at 5:13 am
                                  JerryfromFauq
                                  Participant

                                    i AGREE THAT THE pd-1 tRIALS LOOK LIKE BOTH THE EASIEST AND MOST LIKELY SUCCESFUL TREATMENTS TO GO TO,

                                    I will also point out that Ipi the IL-2 has shown succes in some cases.  

                                    An additional point to remember is that after either Ipi or IL-2 there is a greater chance that older Chemo treatments may be more beneficial then when used as a stand-a-lone chemo.

                                    • May 13, 2013 at 5:13 am
                                    JerryfromFauq
                                    Participant

                                      i AGREE THAT THE pd-1 tRIALS LOOK LIKE BOTH THE EASIEST AND MOST LIKELY SUCCESFUL TREATMENTS TO GO TO,

                                      I will also point out that Ipi the IL-2 has shown succes in some cases.  

                                      An additional point to remember is that after either Ipi or IL-2 there is a greater chance that older Chemo treatments may be more beneficial then when used as a stand-a-lone chemo.

                                        • May 13, 2013 at 5:17 am
                                        JerryfromFauq
                                        Participant

                                          I will also point out that Ipi THEN IL-2 has shown success in some cases.

                                          • May 13, 2013 at 5:17 am
                                          JerryfromFauq
                                          Participant

                                            I will also point out that Ipi THEN IL-2 has shown success in some cases.

                                            • May 13, 2013 at 5:17 am
                                            JerryfromFauq
                                            Participant

                                              I will also point out that Ipi THEN IL-2 has shown success in some cases.

                                            • May 14, 2013 at 7:32 pm
                                            Tamils
                                            Participant

                                              I saw you're in the Davis area; UCSF (Dr. Adil Daud) is recruiting for Merck's anti-PD1 trial.  No randomization. 

                                              http://clinicaltrials.gov/ct2/show/NCT01295827?term=lambrolizumab&rank=1

                                              • May 14, 2013 at 7:32 pm
                                              Tamils
                                              Participant

                                                I saw you're in the Davis area; UCSF (Dr. Adil Daud) is recruiting for Merck's anti-PD1 trial.  No randomization. 

                                                http://clinicaltrials.gov/ct2/show/NCT01295827?term=lambrolizumab&rank=1

                                                • May 14, 2013 at 7:32 pm
                                                Tamils
                                                Participant

                                                  I saw you're in the Davis area; UCSF (Dr. Adil Daud) is recruiting for Merck's anti-PD1 trial.  No randomization. 

                                                  http://clinicaltrials.gov/ct2/show/NCT01295827?term=lambrolizumab&rank=1

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