can ipi stop working within a month or so
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can ipi stop working within a month or so

› Forums › General Melanoma Community › can ipi stop working within a month or so

  • Post
    • November 21, 2011 at 2:30 am
    Terra
    Participant

    Hi

    We had mid Oct scans that showed ipi was working – approx 50% decrease in liver disease – yet he is now feeling some consistent pressure on his lower left side again and the most recent scan did not involve his head where he had a tumour behind his eye (on earlier scan) – he is now thinking his eye looks slightly swollen and feel slightly oily.

     

    Thanks for any possible answers – we more have scan in a month 

    Hi

    We had mid Oct scans that showed ipi was working – approx 50% decrease in liver disease – yet he is now feeling some consistent pressure on his lower left side again and the most recent scan did not involve his head where he had a tumour behind his eye (on earlier scan) – he is now thinking his eye looks slightly swollen and feel slightly oily.

     

    Thanks for any possible answers – we more have scan in a month 

Viewing 8 reply threads
  • Replies
      • November 21, 2011 at 6:24 am
      FormerCaregiver
      Participant

      Terra, I feel that more time is needed to evaluate what is happening. I am not sure if
      ipi has could have stopped working already, but it seems unlikely. From:
      http://meeting.ascopubs.org/cgi/content/abstract/25/18_suppl/8525 "Preliminary results
      suggest that ORs with ipilimumab may be later in onset … and may occur after
      progression. This late onset of effect likely reflects the immune-related
      mechanism of action of ipilimumab …"

      Perhaps it would be wise to discuss your concerns with the oncologist?

      Take care

      Frank from Australia

      • November 21, 2011 at 6:24 am
      FormerCaregiver
      Participant

      Terra, I feel that more time is needed to evaluate what is happening. I am not sure if
      ipi has could have stopped working already, but it seems unlikely. From:
      http://meeting.ascopubs.org/cgi/content/abstract/25/18_suppl/8525 "Preliminary results
      suggest that ORs with ipilimumab may be later in onset … and may occur after
      progression. This late onset of effect likely reflects the immune-related
      mechanism of action of ipilimumab …"

      Perhaps it would be wise to discuss your concerns with the oncologist?

      Take care

      Frank from Australia

      • November 21, 2011 at 6:24 am
      FormerCaregiver
      Participant

      Terra, I feel that more time is needed to evaluate what is happening. I am not sure if
      ipi has could have stopped working already, but it seems unlikely. From:
      http://meeting.ascopubs.org/cgi/content/abstract/25/18_suppl/8525 "Preliminary results
      suggest that ORs with ipilimumab may be later in onset … and may occur after
      progression. This late onset of effect likely reflects the immune-related
      mechanism of action of ipilimumab …"

      Perhaps it would be wise to discuss your concerns with the oncologist?

      Take care

      Frank from Australia

      • November 21, 2011 at 11:37 am
      jmmm
      Participant
      It can happen, even if it’s unusual. My husband received ipi from may-July. His 14 week scan showed of the two tumors he had, one was completely gone, and one was dead and half the size. There was one small new tumor. Over the next two months, more tumors grew. Again, his melanoma specialist (who has used ipi a lot), said it was a very unusual reaction. So, his ipi worked immediately, but stopped working before he even finished the treatment.
      Also keep in mind that sometimes the tumors seem to grow before they shrink. Maybe that’s all that’s happening? Hang in there and know that the reaction can take 4-6 months to show up. Don’t give up yet.
      • November 21, 2011 at 11:37 am
      jmmm
      Participant
      It can happen, even if it’s unusual. My husband received ipi from may-July. His 14 week scan showed of the two tumors he had, one was completely gone, and one was dead and half the size. There was one small new tumor. Over the next two months, more tumors grew. Again, his melanoma specialist (who has used ipi a lot), said it was a very unusual reaction. So, his ipi worked immediately, but stopped working before he even finished the treatment.
      Also keep in mind that sometimes the tumors seem to grow before they shrink. Maybe that’s all that’s happening? Hang in there and know that the reaction can take 4-6 months to show up. Don’t give up yet.
      • November 21, 2011 at 11:37 am
      jmmm
      Participant
      It can happen, even if it’s unusual. My husband received ipi from may-July. His 14 week scan showed of the two tumors he had, one was completely gone, and one was dead and half the size. There was one small new tumor. Over the next two months, more tumors grew. Again, his melanoma specialist (who has used ipi a lot), said it was a very unusual reaction. So, his ipi worked immediately, but stopped working before he even finished the treatment.
      Also keep in mind that sometimes the tumors seem to grow before they shrink. Maybe that’s all that’s happening? Hang in there and know that the reaction can take 4-6 months to show up. Don’t give up yet.
      • November 21, 2011 at 11:37 am
      jmmm
      Participant
      It can happen, even if it’s unusual. My husband received ipi from may-July. His 14 week scan showed of the two tumors he had, one was completely gone, and one was dead and half the size. There was one small new tumor. Over the next two months, more tumors grew. Again, his melanoma specialist (who has used ipi a lot), said it was a very unusual reaction. So, his ipi worked immediately, but stopped working before he even finished the treatment.
      Also keep in mind that sometimes the tumors seem to grow before they shrink. Maybe that’s all that’s happening? Hang in there and know that the reaction can take 4-6 months to show up. Don’t give up yet.
      • November 21, 2011 at 11:37 am
      jmmm
      Participant
      It can happen, even if it’s unusual. My husband received ipi from may-July. His 14 week scan showed of the two tumors he had, one was completely gone, and one was dead and half the size. There was one small new tumor. Over the next two months, more tumors grew. Again, his melanoma specialist (who has used ipi a lot), said it was a very unusual reaction. So, his ipi worked immediately, but stopped working before he even finished the treatment.
      Also keep in mind that sometimes the tumors seem to grow before they shrink. Maybe that’s all that’s happening? Hang in there and know that the reaction can take 4-6 months to show up. Don’t give up yet.
        • November 21, 2011 at 1:21 pm
        Lisa13
        Participant

        Hi Terra,

        I'm sure it's possible that ipi might not work down the road, but if your husbands scan was quite successful, I'd have a hard time believing anything would happen for awhile.  On October 31st, my scans showed 50% regression as well as some were gone.  I had 2 old spots that grew a bit, but we're not sure if this is inflammation.  I have another scan on Nov 30th and as much as I'm nervous about a change in success, I just don't believe that to be true.

        If you're husband is having pain in his lower left side – isn't this the colon/bowel area and not the liver?  The liver is on the right side I thought.  Maybe your husband is getting side effects from ipi which can last months after last treatment. 

        If your husband didn't have any new tumours and had success on all of them, that is good news that will likely stay that way for a while. Besides, if something comes back, he can go on ipi again and have a 50% chance of it working.

        Keep positive. It's so hard not to think the worst sometime and think that every pain we have is cancer.

        Here's hoping the ipi will continue for a long time.

        Lisa

        • November 21, 2011 at 1:21 pm
        Lisa13
        Participant

        Hi Terra,

        I'm sure it's possible that ipi might not work down the road, but if your husbands scan was quite successful, I'd have a hard time believing anything would happen for awhile.  On October 31st, my scans showed 50% regression as well as some were gone.  I had 2 old spots that grew a bit, but we're not sure if this is inflammation.  I have another scan on Nov 30th and as much as I'm nervous about a change in success, I just don't believe that to be true.

        If you're husband is having pain in his lower left side – isn't this the colon/bowel area and not the liver?  The liver is on the right side I thought.  Maybe your husband is getting side effects from ipi which can last months after last treatment. 

        If your husband didn't have any new tumours and had success on all of them, that is good news that will likely stay that way for a while. Besides, if something comes back, he can go on ipi again and have a 50% chance of it working.

        Keep positive. It's so hard not to think the worst sometime and think that every pain we have is cancer.

        Here's hoping the ipi will continue for a long time.

        Lisa

        • November 21, 2011 at 1:21 pm
        Lisa13
        Participant

        Hi Terra,

        I'm sure it's possible that ipi might not work down the road, but if your husbands scan was quite successful, I'd have a hard time believing anything would happen for awhile.  On October 31st, my scans showed 50% regression as well as some were gone.  I had 2 old spots that grew a bit, but we're not sure if this is inflammation.  I have another scan on Nov 30th and as much as I'm nervous about a change in success, I just don't believe that to be true.

        If you're husband is having pain in his lower left side – isn't this the colon/bowel area and not the liver?  The liver is on the right side I thought.  Maybe your husband is getting side effects from ipi which can last months after last treatment. 

        If your husband didn't have any new tumours and had success on all of them, that is good news that will likely stay that way for a while. Besides, if something comes back, he can go on ipi again and have a 50% chance of it working.

        Keep positive. It's so hard not to think the worst sometime and think that every pain we have is cancer.

        Here's hoping the ipi will continue for a long time.

        Lisa

      • November 21, 2011 at 11:37 am
      jmmm
      Participant
      It can happen, even if it’s unusual. My husband received ipi from may-July. His 14 week scan showed of the two tumors he had, one was completely gone, and one was dead and half the size. There was one small new tumor. Over the next two months, more tumors grew. Again, his melanoma specialist (who has used ipi a lot), said it was a very unusual reaction. So, his ipi worked immediately, but stopped working before he even finished the treatment.
      Also keep in mind that sometimes the tumors seem to grow before they shrink. Maybe that’s all that’s happening? Hang in there and know that the reaction can take 4-6 months to show up. Don’t give up yet.
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