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Breaking Tolerance to Invoke an Immune Response to Cancer (Melanoma)
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Breaking Tolerance to Invoke an Immune Response to Cancer (Melanoma)

› Forums › General Melanoma Community › Breaking Tolerance to Invoke an Immune Response to Cancer (Melanoma)

  • Post
    • February 11, 2012 at 2:08 pm
    jim Breitfeller
    Participant

      This post has been in the works for five years. It is with my tenacity and help from researchers around the world I am able to present this paper. It is still in draft form but I thought was important enough to just get it out there. It may be to technical for the average person/patient but, it is well worth downloading and presenting to your oncologist and or medical team.

      This post has been in the works for five years. It is with my tenacity and help from researchers around the world I am able to present this paper. It is still in draft form but I thought was important enough to just get it out there. It may be to technical for the average person/patient but, it is well worth downloading and presenting to your oncologist and or medical team.

      The gist of the paper is we have responders and non-responders to therapy. WHY?? with the help of Four on the most influential researchers in the Melanoma field, Dr. Craig Slingluff, Dr. Thomas Gajewski, Dr.Kingston Mills, Dr. Jim Allison and others, I was able to put some puzzle pieces together to tell a story. A story that may just save your life

      In short, the non-responders may be/are missing the "Danger Signals" inflammatory Cytokines. Why, because their tumors are most likely harboring M2 phenotype macrophages (TAMs) Tumor assisted Macrophages.

      But these TAMs have plasticity. This means they can change phenotype based on their miroenviroment. With some coaxing they can be change into M1 macrophages which in turn actiavate the T-cells. This means the patient needs to have therapies that promote M1 and Th1 cells. Well both Dr. Allison and Dr. Mills have discovered ways to do just that.

      Please take some time to download and read this historic paper. It just may be the game changer for cancer.

       https://www.box.net/s/mzxb1b2o0tue44a3z3xo

       

      I am going end with one slide.

       

       

      “It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change.”

      ~Charles Darwin~
      Take Care,
      Jimmy B

    Viewing 8 reply threads
    • Replies
        • February 11, 2012 at 9:16 pm
        James from Sydney
        Participant

          thanks Jimmy, i will pass this on to someone i know at The Melanoma Institute. 

          best wishes

          James

          • February 11, 2012 at 9:16 pm
          James from Sydney
          Participant

            thanks Jimmy, i will pass this on to someone i know at The Melanoma Institute. 

            best wishes

            James

            • February 11, 2012 at 9:16 pm
            James from Sydney
            Participant

              thanks Jimmy, i will pass this on to someone i know at The Melanoma Institute. 

              best wishes

              James

              • February 13, 2012 at 1:02 am
              FormerCaregiver
              Participant

                Jimmy, thank you for your groundbreaking efforts to provide solutions to an intricate puzzle. I know that it is not easy to get people to take notice of the work that one has been doing. A long time ago, I wrote extensively about an unrelated health topic and it is only recently that the concepts that I discussed have been accepted.

                Best wishes

                Frank from Australia

                • February 13, 2012 at 1:02 am
                FormerCaregiver
                Participant

                  Jimmy, thank you for your groundbreaking efforts to provide solutions to an intricate puzzle. I know that it is not easy to get people to take notice of the work that one has been doing. A long time ago, I wrote extensively about an unrelated health topic and it is only recently that the concepts that I discussed have been accepted.

                  Best wishes

                  Frank from Australia

                  • February 13, 2012 at 1:02 am
                  FormerCaregiver
                  Participant

                    Jimmy, thank you for your groundbreaking efforts to provide solutions to an intricate puzzle. I know that it is not easy to get people to take notice of the work that one has been doing. A long time ago, I wrote extensively about an unrelated health topic and it is only recently that the concepts that I discussed have been accepted.

                    Best wishes

                    Frank from Australia

                    • February 13, 2012 at 3:07 am
                    Tracy Seattle
                    Participant
                      Wondering how this information can be used now? I was a non-responder to Ipilumamab and recently read an interview given by Allison. In the interview, they asked him why he thought some people were responders and others were not. My take of what he said (can’t find the article right now) was that you needed some type of cell death to create inflammation which in turn would help the immune system recognize the tumor or cancer. I took the article to my oncologist and she didn’t really seem to have an idea on what to do with the information. It’s frustrating to say the least. My treatment options are somewhat limited as I am not HLA positive. Starting to look to alternatives but I would be interested in perusing this avenue if you have any suggestions on how to do so.
                        • February 17, 2012 at 9:57 pm
                        boot2aboot
                        Participant

                          thanks Jimmy

                          boots

                          • February 17, 2012 at 9:57 pm
                          boot2aboot
                          Participant

                            thanks Jimmy

                            boots

                            • February 17, 2012 at 9:57 pm
                            boot2aboot
                            Participant

                              thanks Jimmy

                              boots

                            • February 13, 2012 at 3:07 am
                            Tracy Seattle
                            Participant
                              Wondering how this information can be used now? I was a non-responder to Ipilumamab and recently read an interview given by Allison. In the interview, they asked him why he thought some people were responders and others were not. My take of what he said (can’t find the article right now) was that you needed some type of cell death to create inflammation which in turn would help the immune system recognize the tumor or cancer. I took the article to my oncologist and she didn’t really seem to have an idea on what to do with the information. It’s frustrating to say the least. My treatment options are somewhat limited as I am not HLA positive. Starting to look to alternatives but I would be interested in perusing this avenue if you have any suggestions on how to do so.
                              • February 13, 2012 at 3:07 am
                              Tracy Seattle
                              Participant
                                Wondering how this information can be used now? I was a non-responder to Ipilumamab and recently read an interview given by Allison. In the interview, they asked him why he thought some people were responders and others were not. My take of what he said (can’t find the article right now) was that you needed some type of cell death to create inflammation which in turn would help the immune system recognize the tumor or cancer. I took the article to my oncologist and she didn’t really seem to have an idea on what to do with the information. It’s frustrating to say the least. My treatment options are somewhat limited as I am not HLA positive. Starting to look to alternatives but I would be interested in perusing this avenue if you have any suggestions on how to do so.
                            Viewing 8 reply threads
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