› Forums › General Melanoma Community › BRCA2 gene, genetic testing, melanoma, lymphoma
- This topic has 12 replies, 3 voices, and was last updated 11 years, 1 month ago by chalknpens.
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- February 21, 2013 at 8:12 pm
Hi – I'm doing fine myself, having had no new melanoma sites discovered at my three month and six month follow up visits. But I have a relative who has had melanoma for several years, beginniing about a decade ago. She now has lymphoma. And in our family, we have what is called a cancer gene, BRCA 2. That gene is linked to many types of cancer, and it raises the likelihood of developing cancer tremendously.
Hi – I'm doing fine myself, having had no new melanoma sites discovered at my three month and six month follow up visits. But I have a relative who has had melanoma for several years, beginniing about a decade ago. She now has lymphoma. And in our family, we have what is called a cancer gene, BRCA 2. That gene is linked to many types of cancer, and it raises the likelihood of developing cancer tremendously.
Is anyone else familiar with this gene? And have other people with melanoma later been diagnosed with lymphoma, and are the two cancers related? I've alerted my doctor to the family link to BRCA 2, and we are looking into genetic testing.
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- February 22, 2013 at 4:06 am
Some types of Melanoma and some types of lymphoma's, some Leukema's and some varieties of GIST all have C-kit oncoprotiens and c-kit DNA mutations. Was your or your relative's melanoma tumors tested for any of the C-kit mutations? (I have been a Stagae IV c-kit melanoma patient for 6 years now.)
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- February 27, 2013 at 6:38 pm
My melanoma was stage 1 at the surface only; I don't believe there were actual tumors, but as I didn't know about the BRCA 2 gene until recently, I don't think my biopsies would have looked for that. And my neice's melanoma tumors also predated the BRCA2 information in our family. But she is now on a 'watchful waiting' regime with her oncologist, so I'll listen for any direct link to her case. Her sister, also my neice, has just been diagnosed with an aggressive breast cancer and will begin chemotherepy soon.
Thank you for answering my post.
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- February 27, 2013 at 6:38 pm
My melanoma was stage 1 at the surface only; I don't believe there were actual tumors, but as I didn't know about the BRCA 2 gene until recently, I don't think my biopsies would have looked for that. And my neice's melanoma tumors also predated the BRCA2 information in our family. But she is now on a 'watchful waiting' regime with her oncologist, so I'll listen for any direct link to her case. Her sister, also my neice, has just been diagnosed with an aggressive breast cancer and will begin chemotherepy soon.
Thank you for answering my post.
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- February 27, 2013 at 6:38 pm
My melanoma was stage 1 at the surface only; I don't believe there were actual tumors, but as I didn't know about the BRCA 2 gene until recently, I don't think my biopsies would have looked for that. And my neice's melanoma tumors also predated the BRCA2 information in our family. But she is now on a 'watchful waiting' regime with her oncologist, so I'll listen for any direct link to her case. Her sister, also my neice, has just been diagnosed with an aggressive breast cancer and will begin chemotherepy soon.
Thank you for answering my post.
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- February 22, 2013 at 4:06 am
Some types of Melanoma and some types of lymphoma's, some Leukema's and some varieties of GIST all have C-kit oncoprotiens and c-kit DNA mutations. Was your or your relative's melanoma tumors tested for any of the C-kit mutations? (I have been a Stagae IV c-kit melanoma patient for 6 years now.)
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- February 22, 2013 at 4:06 am
Some types of Melanoma and some types of lymphoma's, some Leukema's and some varieties of GIST all have C-kit oncoprotiens and c-kit DNA mutations. Was your or your relative's melanoma tumors tested for any of the C-kit mutations? (I have been a Stagae IV c-kit melanoma patient for 6 years now.)
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- February 27, 2013 at 9:37 pm
My mother was diagnosed with melanoma in her 60s. In her 90s she was diagnosed with lymphoma and died of it. I had breast cancer before my melanoma but was found to be BRCA negative. Our family is being researched by NCI for familial melanoma because there were 3 others in the family that also had it. I believe one of the things they will be looking at will be CDK4. Don't know much about it yet. One of the side points of this is that my mother was never biopsied to definitively determine whether the lymphoma might have been metastatic melanoma. Perhaps the doctor was so sure she felt she did not need a biopsy. But it certainly has left a question in my mind with my own metastatic melanoma emerging 6 years after her death and my mother's doctor refusing to communicate with me because of HIPPA, I presume. Hard to know for sure when a doctor does not return your calls.
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- March 1, 2013 at 5:50 pm
Thank you for your replies. I'll be interviewed by an oncologist – phlebotomist this week, to 'predetermine' whether the genetic testing is 'medically indicated' or not. I'll keep you posted.
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- March 1, 2013 at 5:50 pm
Thank you for your replies. I'll be interviewed by an oncologist – phlebotomist this week, to 'predetermine' whether the genetic testing is 'medically indicated' or not. I'll keep you posted.
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- March 1, 2013 at 5:50 pm
Thank you for your replies. I'll be interviewed by an oncologist – phlebotomist this week, to 'predetermine' whether the genetic testing is 'medically indicated' or not. I'll keep you posted.
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- February 27, 2013 at 9:37 pm
My mother was diagnosed with melanoma in her 60s. In her 90s she was diagnosed with lymphoma and died of it. I had breast cancer before my melanoma but was found to be BRCA negative. Our family is being researched by NCI for familial melanoma because there were 3 others in the family that also had it. I believe one of the things they will be looking at will be CDK4. Don't know much about it yet. One of the side points of this is that my mother was never biopsied to definitively determine whether the lymphoma might have been metastatic melanoma. Perhaps the doctor was so sure she felt she did not need a biopsy. But it certainly has left a question in my mind with my own metastatic melanoma emerging 6 years after her death and my mother's doctor refusing to communicate with me because of HIPPA, I presume. Hard to know for sure when a doctor does not return your calls.
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- February 27, 2013 at 9:37 pm
My mother was diagnosed with melanoma in her 60s. In her 90s she was diagnosed with lymphoma and died of it. I had breast cancer before my melanoma but was found to be BRCA negative. Our family is being researched by NCI for familial melanoma because there were 3 others in the family that also had it. I believe one of the things they will be looking at will be CDK4. Don't know much about it yet. One of the side points of this is that my mother was never biopsied to definitively determine whether the lymphoma might have been metastatic melanoma. Perhaps the doctor was so sure she felt she did not need a biopsy. But it certainly has left a question in my mind with my own metastatic melanoma emerging 6 years after her death and my mother's doctor refusing to communicate with me because of HIPPA, I presume. Hard to know for sure when a doctor does not return your calls.
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