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BRAF/MEK trial, 8 week scan tomorrow

Forums General Melanoma Community BRAF/MEK trial, 8 week scan tomorrow

  • Post
    Bugandi
    Participant

      Hi,

      I have been on the GSK BRAF/Mek trial for 8 weeks now, and go for my first ct scan tomorrow.   Hoping and Praying for good results.  So far, the trial as been ok, but some of the side effects have gotten me.  Extreme joint pain in my feet and hands.  Taking oxycodone for it, which leaves me fatigued.  Otherwise, very few other side effects.  Anyway, wish me luck.

      B

      Hi,

      I have been on the GSK BRAF/Mek trial for 8 weeks now, and go for my first ct scan tomorrow.   Hoping and Praying for good results.  So far, the trial as been ok, but some of the side effects have gotten me.  Extreme joint pain in my feet and hands.  Taking oxycodone for it, which leaves me fatigued.  Otherwise, very few other side effects.  Anyway, wish me luck.

      B

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    • Replies
        dawn dion
        Participant

          Good luck to you – when did your side effects start?  I started the GSK BRAF/Mek trial on 3/3 so far I haven't had any side effects.   Keep us posted.

          Dawn (Stage IV, Florida)

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            Bugandi
            Participant

              Hi Dawn, the first 3-4 weeks were good.  Towards the end of week 4 is when my side effects started, and were at the worst at week 6.  they are better now, but I started taking pain meds at week 6 too.  Hope that helps.  will be discussing with doctor on Thursday as well.

              B

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              dawn dion
              Participant

                 

                Thanks for the info – That makes me feel a better – I had heard it took a few days for the effects to kick in but really wasn't sure what to expect.   Good luck once again – I am crossing my fingers for you!

                Hugs and Smiles

                Dawn (stage IV, Florida )

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                dawn dion
                Participant

                   

                  Thanks for the info – That makes me feel a better – I had heard it took a few days for the effects to kick in but really wasn't sure what to expect.   Good luck once again – I am crossing my fingers for you!

                  Hugs and Smiles

                  Dawn (stage IV, Florida )

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                  Bugandi
                  Participant

                    Hi Dawn, the first 3-4 weeks were good.  Towards the end of week 4 is when my side effects started, and were at the worst at week 6.  they are better now, but I started taking pain meds at week 6 too.  Hope that helps.  will be discussing with doctor on Thursday as well.

                    B

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                  dawn dion
                  Participant

                    Good luck to you – when did your side effects start?  I started the GSK BRAF/Mek trial on 3/3 so far I haven't had any side effects.   Keep us posted.

                    Dawn (Stage IV, Florida)

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                    KellieSue
                    Participant

                      Good luck on your scans. Hoping super happy positive NED thoughts for you. :D

                      I've been on B-RAF for a week and a half now and aside from a bit of diarhhea I haven't had any side effects. Thanks for the heads-up about what may be coming(I know everyone is different.)

                      Kellie(from Iowa) Stage IV on B-RAF

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                      KellieSue
                      Participant

                        Good luck on your scans. Hoping super happy positive NED thoughts for you. :D

                        I've been on B-RAF for a week and a half now and aside from a bit of diarhhea I haven't had any side effects. Thanks for the heads-up about what may be coming(I know everyone is different.)

                        Kellie(from Iowa) Stage IV on B-RAF

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                        Lisa – Aust
                        Participant

                          Hi

                          My partner Craig started the GSK BRAF/MEK trial about 4 weeks ago and his sympts have subsided as time has gone on. He had very sensitive hands and feet and quite bad joint pain. The joint pain is still happening but overall the sympts have reduced. Are you on the phase III trial? We were told that Craig was the first in the world on this particular trial – i wonder how they are different? I guess there are lots going on!

                          All the very best for your scan – Craig will be scanned at 6 weeks, hopefully its good news for both of you.

                          Lisa

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                          Lisa – Aust
                          Participant

                            Hi

                            My partner Craig started the GSK BRAF/MEK trial about 4 weeks ago and his sympts have subsided as time has gone on. He had very sensitive hands and feet and quite bad joint pain. The joint pain is still happening but overall the sympts have reduced. Are you on the phase III trial? We were told that Craig was the first in the world on this particular trial – i wonder how they are different? I guess there are lots going on!

                            All the very best for your scan – Craig will be scanned at 6 weeks, hopefully its good news for both of you.

                            Lisa

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                              killmel
                              Participant

                                Hi Lisa,

                                Is Craig on a GSK Braf/Mek trial that is PHASE 3??? Can you provide the clinical trial gov. link or the NCT number. I would like to read about Craig's trial.

                                Thanks,

                                Wendy

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                                Lisa – Aust
                                Participant

                                  Hi Wendy,

                                  Yeah Craigs trial is phase III, the title is:

                                  "A Phase III Randomised, Open-label Study Comparing GSK2118436 to DTIC in Previously Untreated Subjects with BRAF Mutation Positive Advanced (Stage III) or Metastatic (Stage IV) Melanoma. GSK Protocol: BRF113683

                                  We are at Sir Charles Gairdiner Hospital in Perth

                                  It doesnt mention the MEK part but the onco nurse seemed to think it was? Not sure if the 'B-RAF' term includes MEK ?  

                                  Hope this helps!

                                  Lisa

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                                  Lisa – Aust
                                  Participant

                                    Hi Wendy,

                                    Yeah Craigs trial is phase III, the title is:

                                    "A Phase III Randomised, Open-label Study Comparing GSK2118436 to DTIC in Previously Untreated Subjects with BRAF Mutation Positive Advanced (Stage III) or Metastatic (Stage IV) Melanoma. GSK Protocol: BRF113683

                                    We are at Sir Charles Gairdiner Hospital in Perth

                                    It doesnt mention the MEK part but the onco nurse seemed to think it was? Not sure if the 'B-RAF' term includes MEK ?  

                                    Hope this helps!

                                    Lisa

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                                    killmel
                                    Participant

                                      Hi Lisa,

                                      Is Craig on a GSK Braf/Mek trial that is PHASE 3??? Can you provide the clinical trial gov. link or the NCT number. I would like to read about Craig's trial.

                                      Thanks,

                                      Wendy

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