BRAF/Meck Combo – When did your side effects start?

I've been on the combo since August 2013.  The combo took me from a heavy tumor burden and bleak prognosis to a much more modest tumor burden.  For me, thankfully, the side effects have been very minor (particularly relative to the benefit).  Occasional joint pain, occasional acne.  The side effect that the doctors are most concerned about is high grade fever.

I've been on the combo since August 2013.  The combo took me from a heavy tumor burden and bleak prognosis to a much more modest tumor burden.  For me, thankfully, the side effects have been very minor (particularly relative to the benefit).  Occasional joint pain, occasional acne.  The side effect that the doctors are most concerned about is high grade fever.

I've been on the combo since August 2013.  The combo took me from a heavy tumor burden and bleak prognosis to a much more modest tumor burden.  For me, thankfully, the side effects have been very minor (particularly relative to the benefit).  Occasional joint pain, occasional acne.  The side effect that the doctors are most concerned about is high grade fever.

Side effects and when they start are really variable from person to person. I've been on the combo since December and really have had very few side effects. I had none for at least the first 2 months. I had extra dry skin and some acne, but some of that may have been dry winter air. More recently (last 2 months or so) I've had some very minor folliculitis (body acne) on the backs of my legs (dont' ask me why there and not other areas, I have no idea). That is diminishing at this point as well. Otherwise, really nothing.

Side effects and when they start are really variable from person to person. I've been on the combo since December and really have had very few side effects. I had none for at least the first 2 months. I had extra dry skin and some acne, but some of that may have been dry winter air. More recently (last 2 months or so) I've had some very minor folliculitis (body acne) on the backs of my legs (dont' ask me why there and not other areas, I have no idea). That is diminishing at this point as well. Otherwise, really nothing.

Side effects and when they start are really variable from person to person. I've been on the combo since December and really have had very few side effects. I had none for at least the first 2 months. I had extra dry skin and some acne, but some of that may have been dry winter air. More recently (last 2 months or so) I've had some very minor folliculitis (body acne) on the backs of my legs (dont' ask me why there and not other areas, I have no idea). That is diminishing at this point as well. Otherwise, really nothing.

Hi,

taking the combo since February. I started with Dabrafenib as single drug for a few days while waiting for the other to arrive. The first day I had high fevers and nothing since then.

The onc told me that fevers may mean that you respond well to the drug as your immune system reacts to it.

When I say nothing I mean that I do not know when I am just tired at night after work if this might be worse than normal due to the drug. So nothing that I could really attribute to it.

WIth the tumor burden I had in February when I was dx I would probably not be here anymore without the combo.

So I would say getting these drugs is something to look forward to, not so much to be afraid of. Do not read the list of possible side effects to thoruoghly and worry about whtat could happen to you! My feeling is that the more you are afraid of things, the more likely they occur (just my theory).

Hi,

taking the combo since February. I started with Dabrafenib as single drug for a few days while waiting for the other to arrive. The first day I had high fevers and nothing since then.

The onc told me that fevers may mean that you respond well to the drug as your immune system reacts to it.

When I say nothing I mean that I do not know when I am just tired at night after work if this might be worse than normal due to the drug. So nothing that I could really attribute to it.

WIth the tumor burden I had in February when I was dx I would probably not be here anymore without the combo.

So I would say getting these drugs is something to look forward to, not so much to be afraid of. Do not read the list of possible side effects to thoruoghly and worry about whtat could happen to you! My feeling is that the more you are afraid of things, the more likely they occur (just my theory).

Hi,

taking the combo since February. I started with Dabrafenib as single drug for a few days while waiting for the other to arrive. The first day I had high fevers and nothing since then.

The onc told me that fevers may mean that you respond well to the drug as your immune system reacts to it.

When I say nothing I mean that I do not know when I am just tired at night after work if this might be worse than normal due to the drug. So nothing that I could really attribute to it.

WIth the tumor burden I had in February when I was dx I would probably not be here anymore without the combo.

So I would say getting these drugs is something to look forward to, not so much to be afraid of. Do not read the list of possible side effects to thoruoghly and worry about whtat could happen to you! My feeling is that the more you are afraid of things, the more likely they occur (just my theory).

My husband is taking Dabrafenib only, he started 6 days ago, and the side effects started within hours of him taking the first dose.  He has joint pain, lower back pain, his blood pressure is low (100/80 and he is normally taking drugs for high blood pressure), elevated heart rate (95-105, while before is was around 60), cough, headaches, the sole of his feet are tender and hurt when he's walking.  Also, his face appeared to be flushed, but no fever. The one that really bothers him is the lower back pain, which he describes as thightening muscles (and he's taking Robaxacet) everything else is manageable and they come and go. 

My husband is taking Dabrafenib only, he started 6 days ago, and the side effects started within hours of him taking the first dose.  He has joint pain, lower back pain, his blood pressure is low (100/80 and he is normally taking drugs for high blood pressure), elevated heart rate (95-105, while before is was around 60), cough, headaches, the sole of his feet are tender and hurt when he's walking.  Also, his face appeared to be flushed, but no fever. The one that really bothers him is the lower back pain, which he describes as thightening muscles (and he's taking Robaxacet) everything else is manageable and they come and go. 

My husband is taking Dabrafenib only, he started 6 days ago, and the side effects started within hours of him taking the first dose.  He has joint pain, lower back pain, his blood pressure is low (100/80 and he is normally taking drugs for high blood pressure), elevated heart rate (95-105, while before is was around 60), cough, headaches, the sole of his feet are tender and hurt when he's walking.  Also, his face appeared to be flushed, but no fever. The one that really bothers him is the lower back pain, which he describes as thightening muscles (and he's taking Robaxacet) everything else is manageable and they come and go. 

Hello.

I've been on this drug for six weeks. 

Had joint pains, swelling of feet, folliculitis in legs from second week, some fevers. Nothing that prevented me working full-time. It's different for each person, but I've found this drug easier to tolerate than Zelboraf on its own so far. 

All the best,

Paul

Hello.

I've been on this drug for six weeks. 

Had joint pains, swelling of feet, folliculitis in legs from second week, some fevers. Nothing that prevented me working full-time. It's different for each person, but I've found this drug easier to tolerate than Zelboraf on its own so far. 

All the best,

Paul

Hello.

I've been on this drug for six weeks. 

Had joint pains, swelling of feet, folliculitis in legs from second week, some fevers. Nothing that prevented me working full-time. It's different for each person, but I've found this drug easier to tolerate than Zelboraf on its own so far. 

All the best,

Paul