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braf inhibitor food/particle study for stage iv

Forums General Melanoma Community braf inhibitor food/particle study for stage iv

  • Post
    theonlydrea
    Participant

    i was wondering if anyone has or is currently on the Braf particle or food study. My husband will start on the study here soon.

    everything i have read posted was just on the doseage or double blind study. the dosage they are saying is now se (i beleive it was 300mg ever 12 hours)t, it is not a double blind study and at this point they are testing if food effects it and if the type of form given effects it. If anyone has any information on what to expect and experiences please let me know. 

    i was wondering if anyone has or is currently on the Braf particle or food study. My husband will start on the study here soon.

    everything i have read posted was just on the doseage or double blind study. the dosage they are saying is now se (i beleive it was 300mg ever 12 hours)t, it is not a double blind study and at this point they are testing if food effects it and if the type of form given effects it. If anyone has any information on what to expect and experiences please let me know. 

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  • Replies
      MichaelFL
      Participant

      Can you give more information on the trial, as i am not sure I have the correct one? You can do a search on http://www.clinicaltrial.gov/ and someone will be better able to assist you.

      I looked it up at http://www.clinicaltrial.gov/ct2/show/NCT01264380?term=braf+food+melanoma&rank=1 and if I have the right trial, it states that it is a Single Oral Dose of RO5185426, Followed by Administration of 960 mg RO5185426 Twice Daily to BRAF V600E Positive Metastatic Melanoma Patients.

      This trial is fairly new as it was first received: December 20, 2010, so I do not believe anyone here is on it as yet. I will say that the side effects of the BRAF trials are not so harsh as other treatments.

      Good luck, and keep us posted.

      Michael

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        MichaelFL
        Participant

        I also read your profile an see that IL-2 (interleukin-2) was attempted and with no success. I see that he is BRAF positive, so as I stated in my previous post, this treatment should not be as difficult as the IL-2.

        Good luck and keep us posted!

        Michael

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        MichaelFL
        Participant

        After reading further, I found another trial as well. Is this the one?

        http://www.clinicaltrial.gov/ct2/show/NCT01231568?term=braf+particle&rank=1

        Michael

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        MichaelFL
        Participant

        After reading further, I found another trial as well. Is this the one?

        http://www.clinicaltrial.gov/ct2/show/NCT01231568?term=braf+particle&rank=1

        Michael

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        MichaelFL
        Participant

        I also read your profile an see that IL-2 (interleukin-2) was attempted and with no success. I see that he is BRAF positive, so as I stated in my previous post, this treatment should not be as difficult as the IL-2.

        Good luck and keep us posted!

        Michael

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        theonlydrea
        Participant

        Thanks Michael i will pull up link.

        Information on package given to us about study says : GlaxosmithKline aka GSK

        BRAF genetick screening Food and Particle size study.

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        theonlydrea
        Participant

        genetic.. lol sorry

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        MichaelFL
        Participant

        Yes, I believe the second trial I found is the one. This is also a fairly new trial as it was First Received: October 21, 2010, and only has an enrollment of 28.

        Sounds like your husband needs a high fat diet. Let us know how the trial goes!

        Good luck, and do your best to research your next option!

        You may wish to discuss a drug called Yervoy (also called ipilimumab) as well.

        Michael 

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        theonlydrea
        Participant

        that was on the list of second choice before he did il2 but they feel that braf would be better at this point.  theres another drug too they mentioned but i dont remember

        thanks again

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        Shelby – MRF
        Keymaster

        Hi Andrea,

        I just wanted to let you know that the MRF recently partnered with EmergingMed to offer patients a free clinical trial finder.  It looks like your husband may already be signed up for one, but I just wanted to make sure you knew about the service.  It basically navigates the clinical trial system for you.  Here is the link if you need or want it: http://www.emergingmed.com/networks/MRF/ 

        Let us know if we can help in any way. 

        Shelby – MRF

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        theonlydrea
        Participant

        thanks shelby

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        theonlydrea
        Participant

        thanks shelby

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        Shelby – MRF
        Keymaster

        Hi Andrea,

        I just wanted to let you know that the MRF recently partnered with EmergingMed to offer patients a free clinical trial finder.  It looks like your husband may already be signed up for one, but I just wanted to make sure you knew about the service.  It basically navigates the clinical trial system for you.  Here is the link if you need or want it: http://www.emergingmed.com/networks/MRF/ 

        Let us know if we can help in any way. 

        Shelby – MRF

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        theonlydrea
        Participant

        that was on the list of second choice before he did il2 but they feel that braf would be better at this point.  theres another drug too they mentioned but i dont remember

        thanks again

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        MichaelFL
        Participant

        Yes, I believe the second trial I found is the one. This is also a fairly new trial as it was First Received: October 21, 2010, and only has an enrollment of 28.

        Sounds like your husband needs a high fat diet. Let us know how the trial goes!

        Good luck, and do your best to research your next option!

        You may wish to discuss a drug called Yervoy (also called ipilimumab) as well.

        Michael 

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        theonlydrea
        Participant

        genetic.. lol sorry

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        theonlydrea
        Participant

        Thanks Michael i will pull up link.

        Information on package given to us about study says : GlaxosmithKline aka GSK

        BRAF genetick screening Food and Particle size study.

        Loading spinner
      MichaelFL
      Participant

      Can you give more information on the trial, as i am not sure I have the correct one? You can do a search on http://www.clinicaltrial.gov/ and someone will be better able to assist you.

      I looked it up at http://www.clinicaltrial.gov/ct2/show/NCT01264380?term=braf+food+melanoma&rank=1 and if I have the right trial, it states that it is a Single Oral Dose of RO5185426, Followed by Administration of 960 mg RO5185426 Twice Daily to BRAF V600E Positive Metastatic Melanoma Patients.

      This trial is fairly new as it was first received: December 20, 2010, so I do not believe anyone here is on it as yet. I will say that the side effects of the BRAF trials are not so harsh as other treatments.

      Good luck, and keep us posted.

      Michael

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