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braf inhibitor food/particle study for stage iv
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braf inhibitor food/particle study for stage iv

› Forums › General Melanoma Community › braf inhibitor food/particle study for stage iv

  • Post
    • March 29, 2011 at 12:10 am
    theonlydrea
    Participant

      i was wondering if anyone has or is currently on the Braf particle or food study. My husband will start on the study here soon.

      everything i have read posted was just on the doseage or double blind study. the dosage they are saying is now se (i beleive it was 300mg ever 12 hours)t, it is not a double blind study and at this point they are testing if food effects it and if the type of form given effects it. If anyone has any information on what to expect and experiences please let me know. 

      i was wondering if anyone has or is currently on the Braf particle or food study. My husband will start on the study here soon.

      everything i have read posted was just on the doseage or double blind study. the dosage they are saying is now se (i beleive it was 300mg ever 12 hours)t, it is not a double blind study and at this point they are testing if food effects it and if the type of form given effects it. If anyone has any information on what to expect and experiences please let me know. 

    Viewing 1 reply thread
    • Replies
        • March 29, 2011 at 1:09 am
        MichaelFL
        Participant

          Can you give more information on the trial, as i am not sure I have the correct one? You can do a search on http://www.clinicaltrial.gov/ and someone will be better able to assist you.

          I looked it up at http://www.clinicaltrial.gov/ct2/show/NCT01264380?term=braf+food+melanoma&rank=1 and if I have the right trial, it states that it is a Single Oral Dose of RO5185426, Followed by Administration of 960 mg RO5185426 Twice Daily to BRAF V600E Positive Metastatic Melanoma Patients.

          This trial is fairly new as it was first received: December 20, 2010, so I do not believe anyone here is on it as yet. I will say that the side effects of the BRAF trials are not so harsh as other treatments.

          Good luck, and keep us posted.

          Michael

            • March 29, 2011 at 1:18 am
            MichaelFL
            Participant

              I also read your profile an see that IL-2 (interleukin-2) was attempted and with no success. I see that he is BRAF positive, so as I stated in my previous post, this treatment should not be as difficult as the IL-2.

              Good luck and keep us posted!

              Michael

              • March 29, 2011 at 1:20 am
              MichaelFL
              Participant

                After reading further, I found another trial as well. Is this the one?

                http://www.clinicaltrial.gov/ct2/show/NCT01231568?term=braf+particle&rank=1

                Michael

                • March 29, 2011 at 1:20 am
                MichaelFL
                Participant

                  After reading further, I found another trial as well. Is this the one?

                  http://www.clinicaltrial.gov/ct2/show/NCT01231568?term=braf+particle&rank=1

                  Michael

                  • March 29, 2011 at 1:18 am
                  MichaelFL
                  Participant

                    I also read your profile an see that IL-2 (interleukin-2) was attempted and with no success. I see that he is BRAF positive, so as I stated in my previous post, this treatment should not be as difficult as the IL-2.

                    Good luck and keep us posted!

                    Michael

                    • March 29, 2011 at 1:20 am
                    theonlydrea
                    Participant

                      Thanks Michael i will pull up link.

                      Information on package given to us about study says : GlaxosmithKline aka GSK

                      BRAF genetick screening Food and Particle size study.

                      • March 29, 2011 at 1:21 am
                      theonlydrea
                      Participant

                        genetic.. lol sorry

                        • March 29, 2011 at 1:27 am
                        MichaelFL
                        Participant

                          Yes, I believe the second trial I found is the one. This is also a fairly new trial as it was First Received: October 21, 2010, and only has an enrollment of 28.

                          Sounds like your husband needs a high fat diet. Let us know how the trial goes!

                          Good luck, and do your best to research your next option!

                          You may wish to discuss a drug called Yervoy (also called ipilimumab) as well.

                          Michael 

                          • March 29, 2011 at 1:30 am
                          theonlydrea
                          Participant

                            that was on the list of second choice before he did il2 but they feel that braf would be better at this point.  theres another drug too they mentioned but i dont remember

                            thanks again

                            • March 29, 2011 at 2:05 pm
                            Anonymous
                            Inactive

                              Hi Andrea,

                              I just wanted to let you know that the MRF recently partnered with EmergingMed to offer patients a free clinical trial finder.  It looks like your husband may already be signed up for one, but I just wanted to make sure you knew about the service.  It basically navigates the clinical trial system for you.  Here is the link if you need or want it: http://www.emergingmed.com/networks/MRF/ 

                              Let us know if we can help in any way. 

                              Shelby – MRF

                              • March 29, 2011 at 2:38 pm
                              theonlydrea
                              Participant

                                thanks shelby

                                • March 29, 2011 at 2:38 pm
                                theonlydrea
                                Participant

                                  thanks shelby

                                  • March 29, 2011 at 2:05 pm
                                  Anonymous
                                  Inactive

                                    Hi Andrea,

                                    I just wanted to let you know that the MRF recently partnered with EmergingMed to offer patients a free clinical trial finder.  It looks like your husband may already be signed up for one, but I just wanted to make sure you knew about the service.  It basically navigates the clinical trial system for you.  Here is the link if you need or want it: http://www.emergingmed.com/networks/MRF/ 

                                    Let us know if we can help in any way. 

                                    Shelby – MRF

                                    • March 29, 2011 at 1:30 am
                                    theonlydrea
                                    Participant

                                      that was on the list of second choice before he did il2 but they feel that braf would be better at this point.  theres another drug too they mentioned but i dont remember

                                      thanks again

                                      • March 29, 2011 at 1:27 am
                                      MichaelFL
                                      Participant

                                        Yes, I believe the second trial I found is the one. This is also a fairly new trial as it was First Received: October 21, 2010, and only has an enrollment of 28.

                                        Sounds like your husband needs a high fat diet. Let us know how the trial goes!

                                        Good luck, and do your best to research your next option!

                                        You may wish to discuss a drug called Yervoy (also called ipilimumab) as well.

                                        Michael 

                                        • March 29, 2011 at 1:21 am
                                        theonlydrea
                                        Participant

                                          genetic.. lol sorry

                                          • March 29, 2011 at 1:20 am
                                          theonlydrea
                                          Participant

                                            Thanks Michael i will pull up link.

                                            Information on package given to us about study says : GlaxosmithKline aka GSK

                                            BRAF genetick screening Food and Particle size study.

                                          • March 29, 2011 at 1:09 am
                                          MichaelFL
                                          Participant

                                            Can you give more information on the trial, as i am not sure I have the correct one? You can do a search on http://www.clinicaltrial.gov/ and someone will be better able to assist you.

                                            I looked it up at http://www.clinicaltrial.gov/ct2/show/NCT01264380?term=braf+food+melanoma&rank=1 and if I have the right trial, it states that it is a Single Oral Dose of RO5185426, Followed by Administration of 960 mg RO5185426 Twice Daily to BRAF V600E Positive Metastatic Melanoma Patients.

                                            This trial is fairly new as it was first received: December 20, 2010, so I do not believe anyone here is on it as yet. I will say that the side effects of the BRAF trials are not so harsh as other treatments.

                                            Good luck, and keep us posted.

                                            Michael

                                        Viewing 1 reply thread
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