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Braf Gene mutation
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Braf Gene mutation

› Forums › General Melanoma Community › Braf Gene mutation

  • Post
    • December 26, 2014 at 10:14 pm
    Rosegargala
    Participant
      If I have it does that mean I will be fighting new melanomas all the time ?
    Viewing 5 reply threads
    • Replies
        • December 26, 2014 at 10:40 pm
        Bubbles
        Participant

          No!  Here is a post whose first part may help explain what having BRAF positive melanoma means – http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/02/braf-inhibitors-for-melanoma-dabrafenib.html

          Perhaps that will help a bit.  Best wishes – c

          • December 26, 2014 at 10:40 pm
          Bubbles
          Participant

            No!  Here is a post whose first part may help explain what having BRAF positive melanoma means – http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/02/braf-inhibitors-for-melanoma-dabrafenib.html

            Perhaps that will help a bit.  Best wishes – c

              • December 26, 2014 at 10:55 pm
              Rosegargala
              Participant
                Thanks so much C !!! Wow you sure know how to make me feel better!!! You’re such an inspiration!!!!
                • December 26, 2014 at 10:55 pm
                Rosegargala
                Participant
                  Thanks so much C !!! Wow you sure know how to make me feel better!!! You’re such an inspiration!!!!
                  • December 26, 2014 at 10:55 pm
                  Rosegargala
                  Participant
                    Thanks so much C !!! Wow you sure know how to make me feel better!!! You’re such an inspiration!!!!
                    • December 26, 2014 at 10:56 pm
                    Rosegargala
                    Participant
                      Anxiety is hitting me hard today!!!
                      • December 26, 2014 at 10:56 pm
                      Rosegargala
                      Participant
                        Anxiety is hitting me hard today!!!
                        • December 26, 2014 at 10:56 pm
                        Rosegargala
                        Participant
                          Anxiety is hitting me hard today!!!
                        • December 26, 2014 at 10:40 pm
                        Bubbles
                        Participant

                          No!  Here is a post whose first part may help explain what having BRAF positive melanoma means – http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/02/braf-inhibitors-for-melanoma-dabrafenib.html

                          Perhaps that will help a bit.  Best wishes – c

                          • December 29, 2014 at 2:41 pm
                          sweetaugust
                          Participant

                            Thank you Celeste, for trying to make it easy for us all to understand.  But I still have confusion about my NRAS mutation.  I had seen everyone on here talking about BRAF positive or negative for so long, so I finally asked my doctors if I were BRAF positive or negative.  And they said actually I am wild type with an NRAS mutation.  So I was thrown at that point and didn't really know what to ask from there.  They just mentioned that the NRAS mutation is a bit tougher to treat and that they are working on treatments for it now.  I have forgotten to ask them more questions about that….like….does that mean my melanoma is more aggressive and harder to treat?  Does that mean that the Keytruda has a harder battle to fight to keep me clear and stable and winning this battle?  These are the questions I need to ask to be better informed on my options.  Thanks so much, Laurie

                             

                            • December 29, 2014 at 2:41 pm
                            sweetaugust
                            Participant

                              Thank you Celeste, for trying to make it easy for us all to understand.  But I still have confusion about my NRAS mutation.  I had seen everyone on here talking about BRAF positive or negative for so long, so I finally asked my doctors if I were BRAF positive or negative.  And they said actually I am wild type with an NRAS mutation.  So I was thrown at that point and didn't really know what to ask from there.  They just mentioned that the NRAS mutation is a bit tougher to treat and that they are working on treatments for it now.  I have forgotten to ask them more questions about that….like….does that mean my melanoma is more aggressive and harder to treat?  Does that mean that the Keytruda has a harder battle to fight to keep me clear and stable and winning this battle?  These are the questions I need to ask to be better informed on my options.  Thanks so much, Laurie

                               

                              • December 29, 2014 at 2:41 pm
                              sweetaugust
                              Participant

                                Thank you Celeste, for trying to make it easy for us all to understand.  But I still have confusion about my NRAS mutation.  I had seen everyone on here talking about BRAF positive or negative for so long, so I finally asked my doctors if I were BRAF positive or negative.  And they said actually I am wild type with an NRAS mutation.  So I was thrown at that point and didn't really know what to ask from there.  They just mentioned that the NRAS mutation is a bit tougher to treat and that they are working on treatments for it now.  I have forgotten to ask them more questions about that….like….does that mean my melanoma is more aggressive and harder to treat?  Does that mean that the Keytruda has a harder battle to fight to keep me clear and stable and winning this battle?  These are the questions I need to ask to be better informed on my options.  Thanks so much, Laurie

                                 

                                  • December 30, 2014 at 3:41 am
                                  Bubbles
                                  Participant

                                    Laurie,

                                    NRAS is just another melanoma mutation.  Folks who are BRAF positive, negative, NRAS positive or negative…seem to be responding equally to the anti-PD1 drugs and ipi (Yervoy).  These various mutations do no better and no worse in their response rates to immunotherapies.  BRAF inhibitors, however, only work well for BRAF positive mutations.  However, MEK inhibitors and some other targeted drugs are helping NRAS patients.

                                    Here is a post from my blog that might help:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2013/01/better-news-for-mek-and-brafmek-combos.html

                                    In this interview Weber and Ribas discuss various therapies:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/06/pretty-darn-impressivea-chat-between.html

                                    Particularly this in regard to NRAS targeted therapy:

                                    Targeted therapies
                                    Weber:  "I was very impressed with Sosman's presentation of the CDK-4 inhibitor combined with the MEK inhibitor 162…a 33% response rate, …phase 1 study with only 22 patients….Nonetheless, the NRAS-mutated population – which are BRAF wild-type because the 2 mutations are mutually exclusive – was a relatively hopeless cohort in terms of targeted therapy, and now it looks like there will be a useful and efficacious targeted therapy for at least 15% of melanoma patients who are NRAS-mutated BRAF wild-type."

                                    There is also this link that might be helpful:  http://www.cancercommons.org/2013/07/17/targeting-nras-mutations-in-melanoma/

                                    Hope that helps.  Celeste

                                    • December 30, 2014 at 3:41 am
                                    Bubbles
                                    Participant

                                      Laurie,

                                      NRAS is just another melanoma mutation.  Folks who are BRAF positive, negative, NRAS positive or negative…seem to be responding equally to the anti-PD1 drugs and ipi (Yervoy).  These various mutations do no better and no worse in their response rates to immunotherapies.  BRAF inhibitors, however, only work well for BRAF positive mutations.  However, MEK inhibitors and some other targeted drugs are helping NRAS patients.

                                      Here is a post from my blog that might help:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2013/01/better-news-for-mek-and-brafmek-combos.html

                                      In this interview Weber and Ribas discuss various therapies:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/06/pretty-darn-impressivea-chat-between.html

                                      Particularly this in regard to NRAS targeted therapy:

                                      Targeted therapies
                                      Weber:  "I was very impressed with Sosman's presentation of the CDK-4 inhibitor combined with the MEK inhibitor 162…a 33% response rate, …phase 1 study with only 22 patients….Nonetheless, the NRAS-mutated population – which are BRAF wild-type because the 2 mutations are mutually exclusive – was a relatively hopeless cohort in terms of targeted therapy, and now it looks like there will be a useful and efficacious targeted therapy for at least 15% of melanoma patients who are NRAS-mutated BRAF wild-type."

                                      There is also this link that might be helpful:  http://www.cancercommons.org/2013/07/17/targeting-nras-mutations-in-melanoma/

                                      Hope that helps.  Celeste

                                      • January 2, 2015 at 3:49 pm
                                      sweetaugust
                                      Participant

                                        Thanks so much Celeste, for taking the time to try and help.  It's good to hear that having the NRAS mutation is no better or worse a diagnosis.  My brain is always thinking…and I am always wondering if and when I should come off of the trial…because how much is too much and would it be healthier for my body to come off of it for a bit…or is it better to stay on it?? 

                                        Even though I am totally healthy and feel great right now…these are still the questions I ask myself every single day.

                                        Thanks so much, Laurie

                                        • January 2, 2015 at 3:49 pm
                                        sweetaugust
                                        Participant

                                          Thanks so much Celeste, for taking the time to try and help.  It's good to hear that having the NRAS mutation is no better or worse a diagnosis.  My brain is always thinking…and I am always wondering if and when I should come off of the trial…because how much is too much and would it be healthier for my body to come off of it for a bit…or is it better to stay on it?? 

                                          Even though I am totally healthy and feel great right now…these are still the questions I ask myself every single day.

                                          Thanks so much, Laurie

                                          • January 2, 2015 at 3:49 pm
                                          sweetaugust
                                          Participant

                                            Thanks so much Celeste, for taking the time to try and help.  It's good to hear that having the NRAS mutation is no better or worse a diagnosis.  My brain is always thinking…and I am always wondering if and when I should come off of the trial…because how much is too much and would it be healthier for my body to come off of it for a bit…or is it better to stay on it?? 

                                            Even though I am totally healthy and feel great right now…these are still the questions I ask myself every single day.

                                            Thanks so much, Laurie

                                            • December 30, 2014 at 3:41 am
                                            Bubbles
                                            Participant

                                              Laurie,

                                              NRAS is just another melanoma mutation.  Folks who are BRAF positive, negative, NRAS positive or negative…seem to be responding equally to the anti-PD1 drugs and ipi (Yervoy).  These various mutations do no better and no worse in their response rates to immunotherapies.  BRAF inhibitors, however, only work well for BRAF positive mutations.  However, MEK inhibitors and some other targeted drugs are helping NRAS patients.

                                              Here is a post from my blog that might help:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2013/01/better-news-for-mek-and-brafmek-combos.html

                                              In this interview Weber and Ribas discuss various therapies:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/06/pretty-darn-impressivea-chat-between.html

                                              Particularly this in regard to NRAS targeted therapy:

                                              Targeted therapies
                                              Weber:  "I was very impressed with Sosman's presentation of the CDK-4 inhibitor combined with the MEK inhibitor 162…a 33% response rate, …phase 1 study with only 22 patients….Nonetheless, the NRAS-mutated population – which are BRAF wild-type because the 2 mutations are mutually exclusive – was a relatively hopeless cohort in terms of targeted therapy, and now it looks like there will be a useful and efficacious targeted therapy for at least 15% of melanoma patients who are NRAS-mutated BRAF wild-type."

                                              There is also this link that might be helpful:  http://www.cancercommons.org/2013/07/17/targeting-nras-mutations-in-melanoma/

                                              Hope that helps.  Celeste

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