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BRAF

› Forums › General Melanoma Community › BRAF

  • Post
    • September 17, 2011 at 2:00 pm
    vickykay
    Participant

      Hi, can someone explain BRAF mutation to me where I can understand . I had the BRAF and it came back negative. What does this mean for me?

      Hi, can someone explain BRAF mutation to me where I can understand . I had the BRAF and it came back negative. What does this mean for me?

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    • Replies
        • September 17, 2011 at 2:40 pm
        jim Breitfeller
        Participant

          Some Melanoma tumors (50%) grow using the BRAF pathway. This pathway allow the tumor to survive and proliferate.

           

          Since you don't have the BRAF mutation, the melanoma is using a different pathway to survive and proliferate. This means that the BRAF therapy will not work with your tumor type.

          • September 17, 2011 at 2:40 pm
          jim Breitfeller
          Participant

            Some Melanoma tumors (50%) grow using the BRAF pathway. This pathway allow the tumor to survive and proliferate.

             

            Since you don't have the BRAF mutation, the melanoma is using a different pathway to survive and proliferate. This means that the BRAF therapy will not work with your tumor type.

            • September 17, 2011 at 5:58 pm
            washoegal
            Participant

              The BRAF protein is a key component of the cellular pathways and may become mutated and cause tumor growth.  New BRAF therapies target this mutation to eliminate tumor progression . 

              You had the tumor tested for BRAF and it came back negative.  That means that those therapies that target the BRAF protien would not work for you.  There are still many therapies available to you, Yervoy/Ipi being the newest one approved by the FDA.

              Mary

              Stage 3

                • September 17, 2011 at 6:52 pm
                vickykay
                Participant

                  Thanks so much, this helps alot.

                  • September 17, 2011 at 6:52 pm
                  vickykay
                  Participant

                    Thanks so much, this helps alot.

                  • September 17, 2011 at 5:58 pm
                  washoegal
                  Participant

                    The BRAF protein is a key component of the cellular pathways and may become mutated and cause tumor growth.  New BRAF therapies target this mutation to eliminate tumor progression . 

                    You had the tumor tested for BRAF and it came back negative.  That means that those therapies that target the BRAF protien would not work for you.  There are still many therapies available to you, Yervoy/Ipi being the newest one approved by the FDA.

                    Mary

                    Stage 3

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