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Bone Mets & BRAF Inhibitors
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Bone Mets & BRAF Inhibitors

› Forums › General Melanoma Community › Bone Mets & BRAF Inhibitors

  • Post
    • August 28, 2013 at 3:19 pm
    Mat
    Participant

      Hi Everyone,

      Hi Everyone,

      I've been on the Taflinar-Mekinist combo for about a month now and have had outstanding results.  One nuisance (minor in the scheme of things)–before I started on the combo, I developed a numbness in part of my lower right jaw and chin.  The sensation is similar to the effect of a shot of novacane at a dentist's office (albeit one that never goes away).  An MRI revealed a lesion in my jaw–likely bumping-up against a nerve.  The combo has not resolved the issue.  Any thoughts?  Is it the case that BRAF inhibitors somehow "don't get to" bone mets?  Thanks in advance for your replies.

      Mat

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    • Replies
        • August 29, 2013 at 5:42 am
        Lisa – Aust
        Participant
          Hi Mat,
          My husband was on a braf inhibitor for 2.5 years after progressing with 2 mets – one to his rib and one to a lymph node in his abdo area. He was lucky enough to have a complete response – so the rib met is barely detectable on scans. He also had radiation to the rib just prior to starting the trial – so unsure which had the effect – but at this point, the rib is still fine. He does still complain of achey-ness around the rib, but i guess he has essentially had a pathological fracture which has healed – so that isnt completely surprising. Unfort the lymph node has just started growing again, so he’s had to come off the trial and will hopefully start a new one soon 🙂
          Not sure if this is helpful, but he certainly had good results with braf for his bone met.
          Cheers, Lisa
          • August 29, 2013 at 5:42 am
          Lisa – Aust
          Participant
            Hi Mat,
            My husband was on a braf inhibitor for 2.5 years after progressing with 2 mets – one to his rib and one to a lymph node in his abdo area. He was lucky enough to have a complete response – so the rib met is barely detectable on scans. He also had radiation to the rib just prior to starting the trial – so unsure which had the effect – but at this point, the rib is still fine. He does still complain of achey-ness around the rib, but i guess he has essentially had a pathological fracture which has healed – so that isnt completely surprising. Unfort the lymph node has just started growing again, so he’s had to come off the trial and will hopefully start a new one soon 🙂
            Not sure if this is helpful, but he certainly had good results with braf for his bone met.
            Cheers, Lisa
            • August 29, 2013 at 5:42 am
            Lisa – Aust
            Participant
              Hi Mat,
              My husband was on a braf inhibitor for 2.5 years after progressing with 2 mets – one to his rib and one to a lymph node in his abdo area. He was lucky enough to have a complete response – so the rib met is barely detectable on scans. He also had radiation to the rib just prior to starting the trial – so unsure which had the effect – but at this point, the rib is still fine. He does still complain of achey-ness around the rib, but i guess he has essentially had a pathological fracture which has healed – so that isnt completely surprising. Unfort the lymph node has just started growing again, so he’s had to come off the trial and will hopefully start a new one soon 🙂
              Not sure if this is helpful, but he certainly had good results with braf for his bone met.
              Cheers, Lisa
          Viewing 2 reply threads
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