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Anyone with experience switching to Opdivo/Yervoy from Keytruda?
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Anyone with experience switching to Opdivo/Yervoy from Keytruda?

› Forums › General Melanoma Community › Anyone with experience switching to Opdivo/Yervoy from Keytruda?

  • Post
    • October 16, 2015 at 5:24 am
    AnitaLoree
    Participant

      After 1 yr of apparent PFS on Keytruda, latest MRI shows probable enlargement of nasty mel remnant curled around my husband's cervical spinal cord. Oncs huddled & agreed likely new growth on tailend. No new neuro signs/symptoms—yet.

      Only option is to switch to Opdivo/Yervoy combo, which we knew was down the road if…….   Only SE's on Keytruda: fatigue & itching. Didn't start w Ipi because initial tumor swelling common & no place to swell.  Now, out of options for his rare tumor location so will give it a run. (I'm silently) Very anxious re risk of swelling, husband calm, pragmatic.

      Just reread Celeste's 9/27 post re: 'Sequential Nivo then Ipi w encouraging 41% ORR' that helped dry the tears (thank you C)

      Will appreciate hearing from anyone who's done this switch, advice, encouragement (!!!)

      (Husband is BRAF neg, s/p resection, radiation, tumor is non-biopsy-able, non-injectionable, Kaiser pt, but have very good Onc, on top of game, & had consult @ UCSF w Dr Daud—before starting Keytruda)

      Blessings on you all, strength, and courage.  A.L.

       

       

       

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    • Replies
        • October 17, 2015 at 5:54 am
        Patina
        Participant

          I replied to this at 10:54pm PST on 10/16/15.

          Have you had a second opinion from a radiation oncologist about using gamma knife radiation for the new tumor?  

            • October 18, 2015 at 1:55 am
            AnitaLoree
            Participant

              Patina:  Thx for the advice.  We do have a cyberknife specialist doc w/i Kaiser whom my husband has seen for eval of doing c/k after his resection surgery.  Wasn't applicable then but it just might be now. It would be a good idea if she took a look at this latest MRI. He wasn't going send her the MRI and ask what she thinks, but I will encourage him to do so.  What's to lose? A.L.

              • October 19, 2015 at 6:56 pm
              AnitaLoree
              Participant

                Patina: Follow up re your advice.  Husband then did send his MRI to his c/k radiation specialist for her opinion.  She is taking it to radiology grand rounds tomorrow.  We may/may not like their opinion but will appreciate the pooled expertise. A.L.

                • October 19, 2015 at 6:56 pm
                AnitaLoree
                Participant

                  Patina: Follow up re your advice.  Husband then did send his MRI to his c/k radiation specialist for her opinion.  She is taking it to radiology grand rounds tomorrow.  We may/may not like their opinion but will appreciate the pooled expertise. A.L.

                  • October 19, 2015 at 6:56 pm
                  AnitaLoree
                  Participant

                    Patina: Follow up re your advice.  Husband then did send his MRI to his c/k radiation specialist for her opinion.  She is taking it to radiology grand rounds tomorrow.  We may/may not like their opinion but will appreciate the pooled expertise. A.L.

                    • October 18, 2015 at 1:55 am
                    AnitaLoree
                    Participant

                      Patina:  Thx for the advice.  We do have a cyberknife specialist doc w/i Kaiser whom my husband has seen for eval of doing c/k after his resection surgery.  Wasn't applicable then but it just might be now. It would be a good idea if she took a look at this latest MRI. He wasn't going send her the MRI and ask what she thinks, but I will encourage him to do so.  What's to lose? A.L.

                      • October 18, 2015 at 1:55 am
                      AnitaLoree
                      Participant

                        Patina:  Thx for the advice.  We do have a cyberknife specialist doc w/i Kaiser whom my husband has seen for eval of doing c/k after his resection surgery.  Wasn't applicable then but it just might be now. It would be a good idea if she took a look at this latest MRI. He wasn't going send her the MRI and ask what she thinks, but I will encourage him to do so.  What's to lose? A.L.

                      • October 17, 2015 at 5:54 am
                      Patina
                      Participant

                        I replied to this at 10:54pm PST on 10/16/15.

                        Have you had a second opinion from a radiation oncologist about using gamma knife radiation for the new tumor?  

                        • October 17, 2015 at 5:54 am
                        Patina
                        Participant

                          I replied to this at 10:54pm PST on 10/16/15.

                          Have you had a second opinion from a radiation oncologist about using gamma knife radiation for the new tumor?  

                      Viewing 2 reply threads
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