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Any Merck anti PD-1 results?
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Any Merck anti PD-1 results?

› Forums › General Melanoma Community › Any Merck anti PD-1 results?

  • Post
    • March 9, 2012 at 5:04 am
    rbruce
    Participant

      just checking in to see if anyone has any results or comments to share from Merck's pd1 trial?  I start next week and would like to keep in touch with others n the trial.  Thanks, Robert

      just checking in to see if anyone has any results or comments to share from Merck's pd1 trial?  I start next week and would like to keep in touch with others n the trial.  Thanks, Robert

    Viewing 5 reply threads
    • Replies
        • March 9, 2012 at 3:20 pm
        killmel
        Participant

          Hi Robert,

           

          That is great news that you are able to start the Merck trial. I am loking for a anti-pd1 trial.

          Where is the trial? How often do you get the infusions? Anthing else you can tell us about the trial would be greatly appreciated.

          Good Luck with the trial!

          Mike

            • March 9, 2012 at 9:02 pm
            rbruce
            Participant

              Mike, i will be at UCSF with Dr. Daud.   To start,  10 mg infusions will be every 2 weeks but there is rumor of an ammendment that will change it to every 3 weeks.  What therapies have you completed?  Are you braf+, or what mutation are you?  Robert

              • March 9, 2012 at 9:02 pm
              rbruce
              Participant

                Mike, i will be at UCSF with Dr. Daud.   To start,  10 mg infusions will be every 2 weeks but there is rumor of an ammendment that will change it to every 3 weeks.  What therapies have you completed?  Are you braf+, or what mutation are you?  Robert

                • March 9, 2012 at 9:02 pm
                rbruce
                Participant

                  Mike, i will be at UCSF with Dr. Daud.   To start,  10 mg infusions will be every 2 weeks but there is rumor of an ammendment that will change it to every 3 weeks.  What therapies have you completed?  Are you braf+, or what mutation are you?  Robert

                  • March 9, 2012 at 10:14 pm
                  audgator
                  Participant

                    Mike, I start an anti-pd1 trial on Tuesday at Moffitt. It will be every other week for 12 weeks then another 12 weeks if I'm stable or improving.    Dan

                    • March 10, 2012 at 6:57 am
                    LynnLuc
                    Participant

                      Good Luck Dan! Its good you didn't need the right HLA in your Arm of the trial…I guess it's the peptides that required the specific HLA type! Perhaps I will see you down there…don't forget to check with the Social Worker about the other issue…Lynn

                      • March 10, 2012 at 6:57 am
                      LynnLuc
                      Participant

                        Good Luck Dan! Its good you didn't need the right HLA in your Arm of the trial…I guess it's the peptides that required the specific HLA type! Perhaps I will see you down there…don't forget to check with the Social Worker about the other issue…Lynn

                        • March 10, 2012 at 6:57 am
                        LynnLuc
                        Participant

                          Good Luck Dan! Its good you didn't need the right HLA in your Arm of the trial…I guess it's the peptides that required the specific HLA type! Perhaps I will see you down there…don't forget to check with the Social Worker about the other issue…Lynn

                          • March 10, 2012 at 6:58 am
                          LynnLuc
                          Participant

                            PS you may get a red flush the first few times you get it….

                            • March 10, 2012 at 6:58 am
                            LynnLuc
                            Participant

                              PS you may get a red flush the first few times you get it….

                              • March 10, 2012 at 6:58 am
                              LynnLuc
                              Participant

                                PS you may get a red flush the first few times you get it….

                                • March 9, 2012 at 10:14 pm
                                audgator
                                Participant

                                  Mike, I start an anti-pd1 trial on Tuesday at Moffitt. It will be every other week for 12 weeks then another 12 weeks if I'm stable or improving.    Dan

                                  • March 9, 2012 at 10:14 pm
                                  audgator
                                  Participant

                                    Mike, I start an anti-pd1 trial on Tuesday at Moffitt. It will be every other week for 12 weeks then another 12 weeks if I'm stable or improving.    Dan

                                  • March 9, 2012 at 3:20 pm
                                  killmel
                                  Participant

                                    Hi Robert,

                                     

                                    That is great news that you are able to start the Merck trial. I am loking for a anti-pd1 trial.

                                    Where is the trial? How often do you get the infusions? Anthing else you can tell us about the trial would be greatly appreciated.

                                    Good Luck with the trial!

                                    Mike

                                    • March 9, 2012 at 3:20 pm
                                    killmel
                                    Participant

                                      Hi Robert,

                                       

                                      That is great news that you are able to start the Merck trial. I am loking for a anti-pd1 trial.

                                      Where is the trial? How often do you get the infusions? Anthing else you can tell us about the trial would be greatly appreciated.

                                      Good Luck with the trial!

                                      Mike

                                      • March 10, 2012 at 3:07 am
                                      melmar
                                      Participant
                                        Robert – Glad to hear you are starting on anti pd-1. I have not posted on this forum before. As a recently diagnosed stage 4 melanoma patient I have spent countless hours on this site learning as much as possible but haven’t had much to contribute until now. (thank you by the way to all of the knowledgeable posters helping us newbies find our way). Anyway, I started on merck 3475 trial at the Angeles clinic in January after researching a number of trials and doctors. Like you, i go every two weeks for infusions. (The clinic is amazing by the way) I just finished my fourth treatment and have had virtually no side effects worth mentioning. It is early in the trial, but I am told they are seeing good results. I am so hopeful and will stay in touch as I learn more.
                                          • March 10, 2012 at 8:05 am
                                          rbruce
                                          Participant

                                            Thanks for your post, its great to hear about minimal side effects.  Do they do a pre infusion medication of any kind? Is Hamid your doctor? i'll check out your profile.  I'd love to stay in touch as there are not many in the trial and it will be good to share exoeriences.  God bless and take care.  Robert

                                            • March 10, 2012 at 8:05 am
                                            rbruce
                                            Participant

                                              Thanks for your post, its great to hear about minimal side effects.  Do they do a pre infusion medication of any kind? Is Hamid your doctor? i'll check out your profile.  I'd love to stay in touch as there are not many in the trial and it will be good to share exoeriences.  God bless and take care.  Robert

                                              • March 10, 2012 at 8:05 am
                                              rbruce
                                              Participant

                                                Thanks for your post, its great to hear about minimal side effects.  Do they do a pre infusion medication of any kind? Is Hamid your doctor? i'll check out your profile.  I'd love to stay in touch as there are not many in the trial and it will be good to share exoeriences.  God bless and take care.  Robert

                                                • March 10, 2012 at 10:34 am
                                                melmar
                                                Participant
                                                  Robert,
                                                  There are no pre-infusion medications — Just labs followed by 1/2 hour infusion every other week. Dr. Hamid is my doctor. I haven’t yet created a profile but will do so after this post. Thanks again to you and others for sharing their experiences. I am so thankful to have found this site and will happily stay in touch regarding this trial. My thoughts and prayers go to you and others on this site fighting the battle.
                                                  Margo
                                                  • March 12, 2012 at 8:10 pm
                                                  boot2aboot
                                                  Participant

                                                    Robert,

                                                    my onc said that the Bristol Myers (older anti PD1) made some of her stage 4 patients NED…i can't get on it until Zelboraf quits working…

                                                    boots

                                                    • March 12, 2012 at 8:10 pm
                                                    boot2aboot
                                                    Participant

                                                      Robert,

                                                      my onc said that the Bristol Myers (older anti PD1) made some of her stage 4 patients NED…i can't get on it until Zelboraf quits working…

                                                      boots

                                                      • March 13, 2012 at 12:16 am
                                                      rbruce
                                                      Participant
                                                        Thanks Boots for the encouraging words. I’m in SF for labs today, biopsy tomorrow and infusion on Thursday. I’ll.let u know how it goes. Robert
                                                        • March 16, 2012 at 12:35 am
                                                        killmel
                                                        Participant

                                                          Hi Robert,

                                                          How oftern do you get infusions for this drug?? What are the side effects??

                                                          Wishing you good luck with this trial.

                                                          Mary

                                                          • March 16, 2012 at 12:35 am
                                                          killmel
                                                          Participant

                                                            Hi Robert,

                                                            How oftern do you get infusions for this drug?? What are the side effects??

                                                            Wishing you good luck with this trial.

                                                            Mary

                                                            • March 16, 2012 at 12:35 am
                                                            killmel
                                                            Participant

                                                              Hi Robert,

                                                              How oftern do you get infusions for this drug?? What are the side effects??

                                                              Wishing you good luck with this trial.

                                                              Mary

                                                              • March 13, 2012 at 12:16 am
                                                              rbruce
                                                              Participant
                                                                Thanks Boots for the encouraging words. I’m in SF for labs today, biopsy tomorrow and infusion on Thursday. I’ll.let u know how it goes. Robert
                                                                • March 13, 2012 at 12:16 am
                                                                rbruce
                                                                Participant
                                                                  Thanks Boots for the encouraging words. I’m in SF for labs today, biopsy tomorrow and infusion on Thursday. I’ll.let u know how it goes. Robert
                                                                  • March 12, 2012 at 8:10 pm
                                                                  boot2aboot
                                                                  Participant

                                                                    Robert,

                                                                    my onc said that the Bristol Myers (older anti PD1) made some of her stage 4 patients NED…i can't get on it until Zelboraf quits working…

                                                                    boots

                                                                    • March 10, 2012 at 10:34 am
                                                                    melmar
                                                                    Participant
                                                                      Robert,
                                                                      There are no pre-infusion medications — Just labs followed by 1/2 hour infusion every other week. Dr. Hamid is my doctor. I haven’t yet created a profile but will do so after this post. Thanks again to you and others for sharing their experiences. I am so thankful to have found this site and will happily stay in touch regarding this trial. My thoughts and prayers go to you and others on this site fighting the battle.
                                                                      Margo
                                                                      • March 10, 2012 at 10:34 am
                                                                      melmar
                                                                      Participant
                                                                        Robert,
                                                                        There are no pre-infusion medications — Just labs followed by 1/2 hour infusion every other week. Dr. Hamid is my doctor. I haven’t yet created a profile but will do so after this post. Thanks again to you and others for sharing their experiences. I am so thankful to have found this site and will happily stay in touch regarding this trial. My thoughts and prayers go to you and others on this site fighting the battle.
                                                                        Margo
                                                                        • March 16, 2012 at 12:39 am
                                                                        killmel
                                                                        Participant

                                                                          Hi,

                                                                           

                                                                          I read your profile that state you live in Alaska.

                                                                          How do you get infusions every 2 weeks…do you commute from Alaska?

                                                                          Good Luckwith your trial.

                                                                          Dave

                                                                          • March 16, 2012 at 12:39 am
                                                                          killmel
                                                                          Participant

                                                                            Hi,

                                                                             

                                                                            I read your profile that state you live in Alaska.

                                                                            How do you get infusions every 2 weeks…do you commute from Alaska?

                                                                            Good Luckwith your trial.

                                                                            Dave

                                                                            • March 16, 2012 at 12:39 am
                                                                            killmel
                                                                            Participant

                                                                              Hi,

                                                                               

                                                                              I read your profile that state you live in Alaska.

                                                                              How do you get infusions every 2 weeks…do you commute from Alaska?

                                                                              Good Luckwith your trial.

                                                                              Dave

                                                                              • March 16, 2012 at 12:42 am
                                                                              killmel
                                                                              Participant

                                                                                Hi Margo

                                                                                 

                                                                                 

                                                                                I read your profile that state you live in Alaska.

                                                                                How do you get infusions every 2 weeks…do you commute from Alaska?

                                                                                Good Luckwith your trial.

                                                                                Dave

                                                                                • March 19, 2012 at 4:55 am
                                                                                melmar
                                                                                Participant

                                                                                  Yes.  I travel from Alaska every two weeks.  It is a bit of logistical nightmare — not to mention expense, but I also really like the clinic / Dr. Hamid and am very optimistic about the trial.  I guess my motto should be "will travel for cure".        

                                                                                  • March 19, 2012 at 4:55 am
                                                                                  melmar
                                                                                  Participant

                                                                                    Yes.  I travel from Alaska every two weeks.  It is a bit of logistical nightmare — not to mention expense, but I also really like the clinic / Dr. Hamid and am very optimistic about the trial.  I guess my motto should be "will travel for cure".        

                                                                                    • March 19, 2012 at 4:55 am
                                                                                    melmar
                                                                                    Participant

                                                                                      Yes.  I travel from Alaska every two weeks.  It is a bit of logistical nightmare — not to mention expense, but I also really like the clinic / Dr. Hamid and am very optimistic about the trial.  I guess my motto should be "will travel for cure".        

                                                                                      • March 16, 2012 at 12:42 am
                                                                                      killmel
                                                                                      Participant

                                                                                        Hi Margo

                                                                                         

                                                                                         

                                                                                        I read your profile that state you live in Alaska.

                                                                                        How do you get infusions every 2 weeks…do you commute from Alaska?

                                                                                        Good Luckwith your trial.

                                                                                        Dave

                                                                                        • March 16, 2012 at 12:42 am
                                                                                        killmel
                                                                                        Participant

                                                                                          Hi Margo

                                                                                           

                                                                                           

                                                                                          I read your profile that state you live in Alaska.

                                                                                          How do you get infusions every 2 weeks…do you commute from Alaska?

                                                                                          Good Luckwith your trial.

                                                                                          Dave

                                                                                        • March 10, 2012 at 3:07 am
                                                                                        melmar
                                                                                        Participant
                                                                                          Robert – Glad to hear you are starting on anti pd-1. I have not posted on this forum before. As a recently diagnosed stage 4 melanoma patient I have spent countless hours on this site learning as much as possible but haven’t had much to contribute until now. (thank you by the way to all of the knowledgeable posters helping us newbies find our way). Anyway, I started on merck 3475 trial at the Angeles clinic in January after researching a number of trials and doctors. Like you, i go every two weeks for infusions. (The clinic is amazing by the way) I just finished my fourth treatment and have had virtually no side effects worth mentioning. It is early in the trial, but I am told they are seeing good results. I am so hopeful and will stay in touch as I learn more.
                                                                                          • March 10, 2012 at 3:07 am
                                                                                          melmar
                                                                                          Participant
                                                                                            Robert – Glad to hear you are starting on anti pd-1. I have not posted on this forum before. As a recently diagnosed stage 4 melanoma patient I have spent countless hours on this site learning as much as possible but haven’t had much to contribute until now. (thank you by the way to all of the knowledgeable posters helping us newbies find our way). Anyway, I started on merck 3475 trial at the Angeles clinic in January after researching a number of trials and doctors. Like you, i go every two weeks for infusions. (The clinic is amazing by the way) I just finished my fourth treatment and have had virtually no side effects worth mentioning. It is early in the trial, but I am told they are seeing good results. I am so hopeful and will stay in touch as I learn more.
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