› Forums › General Melanoma Community › Anti-PD1 as first line??? From the experts…
- This topic has 12 replies, 4 voices, and was last updated 9 years, 6 months ago by AnitaLoree.
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- October 26, 2014 at 3:27 pm
Hi all,
Saw this article from Clinical Oncology News, Oct 2014, last night and figured some of you might want to hear what the experts are thinking on the notion of anti-PD1 as a first line therapy for melanoma!!! Quotes and a link here if you like….
Fingers crossed! Wishing you all my best. Celeste
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- October 26, 2014 at 5:43 pm
Thanks for the article Celeste!!!! It only makes sense based on the #'s, and the Science has to be solid with the trials. As a little mouse in the Nivo vs Ipi vs combo trial, I feel part of the Science aspect. Have a great Sunday!!! Ed
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- October 26, 2014 at 5:43 pm
Thanks for the article Celeste!!!! It only makes sense based on the #'s, and the Science has to be solid with the trials. As a little mouse in the Nivo vs Ipi vs combo trial, I feel part of the Science aspect. Have a great Sunday!!! Ed
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- October 26, 2014 at 5:43 pm
Thanks for the article Celeste!!!! It only makes sense based on the #'s, and the Science has to be solid with the trials. As a little mouse in the Nivo vs Ipi vs combo trial, I feel part of the Science aspect. Have a great Sunday!!! Ed
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- October 27, 2014 at 2:14 pm
Thanks Celeste!
As a patient that is on the pembro Merck trial, hightest dose, without any prior treatment of any kind, and is BRAF wild type, I feel quite lucky that I had such a great response. The more I read, the more I appreciate it and the luckier I feel.
All my best, Laurie
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- October 27, 2014 at 2:14 pm
Thanks Celeste!
As a patient that is on the pembro Merck trial, hightest dose, without any prior treatment of any kind, and is BRAF wild type, I feel quite lucky that I had such a great response. The more I read, the more I appreciate it and the luckier I feel.
All my best, Laurie
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- October 27, 2014 at 2:14 pm
Thanks Celeste!
As a patient that is on the pembro Merck trial, hightest dose, without any prior treatment of any kind, and is BRAF wild type, I feel quite lucky that I had such a great response. The more I read, the more I appreciate it and the luckier I feel.
All my best, Laurie
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- October 28, 2014 at 1:47 pm
Thank you as always Celeste. Still clawing my way to Keytruda, with my second Yervoy infusion yesterday. A little at odds with my oncologist over this. While he recognizes I don't have the luxury of time, he is still optimistic about the Yervoy, despite all of my mets being brain and CNS related. Will finally have a determination in a few weeks if I'm an official fail and can move on.
Your tireless research and support of us all means so much to us.
Bless,
kali-
- October 28, 2014 at 9:08 pm
Thx Celeste, article will cheer my husband, likes (good) stats. Due for 3rd Keytruda infusion next wk. No SE's :-)) …so far. His will be an interesting response if happens. His residual mel is sitting at the top of his spinal column, C1-2, resected 10/13, BRAF neg. We requested/got external beam radiation 2/14. Otherwise tx naive. PETs neg for any other sites. Origin unk. Nobody's known what to do with him. Fortunately no detectable new neuro sx besides inital mel invasion damage of spinal cord and surgical scraping. Requested UCSF ref: recommendation was to put him in ipi/pembro clincal trial. If got ipi arm, potential risk of residual tumor swellling and further neuro damage not acceptable to us.
Wow! So lucky. Pembro approval came in so much earlier than expected! Kaiser was ready & his oncologist had him on by following wk. While I was concerned not being in a top mel tx ctr, we think the management is going well, competent infusion professionals, interested oncologist who's gone to bat for husband, got him on Keytruda w/o having to take Yervoy. So, we hope to post good news re Keytruda meets CNS mel sites in month or so after today's PET results, next MRI & 4th infusion.
Learn so much here. All your experiences/insights have helped guide my research & support for husband. True Warriors. Hope we'll be able to add something worthwhile. Rooting for all of you. A.L.
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- October 28, 2014 at 9:08 pm
Thx Celeste, article will cheer my husband, likes (good) stats. Due for 3rd Keytruda infusion next wk. No SE's :-)) …so far. His will be an interesting response if happens. His residual mel is sitting at the top of his spinal column, C1-2, resected 10/13, BRAF neg. We requested/got external beam radiation 2/14. Otherwise tx naive. PETs neg for any other sites. Origin unk. Nobody's known what to do with him. Fortunately no detectable new neuro sx besides inital mel invasion damage of spinal cord and surgical scraping. Requested UCSF ref: recommendation was to put him in ipi/pembro clincal trial. If got ipi arm, potential risk of residual tumor swellling and further neuro damage not acceptable to us.
Wow! So lucky. Pembro approval came in so much earlier than expected! Kaiser was ready & his oncologist had him on by following wk. While I was concerned not being in a top mel tx ctr, we think the management is going well, competent infusion professionals, interested oncologist who's gone to bat for husband, got him on Keytruda w/o having to take Yervoy. So, we hope to post good news re Keytruda meets CNS mel sites in month or so after today's PET results, next MRI & 4th infusion.
Learn so much here. All your experiences/insights have helped guide my research & support for husband. True Warriors. Hope we'll be able to add something worthwhile. Rooting for all of you. A.L.
-
- October 28, 2014 at 9:08 pm
Thx Celeste, article will cheer my husband, likes (good) stats. Due for 3rd Keytruda infusion next wk. No SE's :-)) …so far. His will be an interesting response if happens. His residual mel is sitting at the top of his spinal column, C1-2, resected 10/13, BRAF neg. We requested/got external beam radiation 2/14. Otherwise tx naive. PETs neg for any other sites. Origin unk. Nobody's known what to do with him. Fortunately no detectable new neuro sx besides inital mel invasion damage of spinal cord and surgical scraping. Requested UCSF ref: recommendation was to put him in ipi/pembro clincal trial. If got ipi arm, potential risk of residual tumor swellling and further neuro damage not acceptable to us.
Wow! So lucky. Pembro approval came in so much earlier than expected! Kaiser was ready & his oncologist had him on by following wk. While I was concerned not being in a top mel tx ctr, we think the management is going well, competent infusion professionals, interested oncologist who's gone to bat for husband, got him on Keytruda w/o having to take Yervoy. So, we hope to post good news re Keytruda meets CNS mel sites in month or so after today's PET results, next MRI & 4th infusion.
Learn so much here. All your experiences/insights have helped guide my research & support for husband. True Warriors. Hope we'll be able to add something worthwhile. Rooting for all of you. A.L.
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- October 28, 2014 at 1:47 pm
Thank you as always Celeste. Still clawing my way to Keytruda, with my second Yervoy infusion yesterday. A little at odds with my oncologist over this. While he recognizes I don't have the luxury of time, he is still optimistic about the Yervoy, despite all of my mets being brain and CNS related. Will finally have a determination in a few weeks if I'm an official fail and can move on.
Your tireless research and support of us all means so much to us.
Bless,
kali -
- October 28, 2014 at 1:47 pm
Thank you as always Celeste. Still clawing my way to Keytruda, with my second Yervoy infusion yesterday. A little at odds with my oncologist over this. While he recognizes I don't have the luxury of time, he is still optimistic about the Yervoy, despite all of my mets being brain and CNS related. Will finally have a determination in a few weeks if I'm an official fail and can move on.
Your tireless research and support of us all means so much to us.
Bless,
kali
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