Anti PD-1 Trials
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Anti PD-1 Trials

› Forums › General Melanoma Community › Anti PD-1 Trials

  • Post
    • April 29, 2013 at 12:51 pm
    lrkg1234
    Participant

    Does anyone know of possible anti PD-1 trial openings for patients previously treated with IPI? 

    We are in Indianapolis so anywhere within an 8 hour drive would be best.

    What is the best link to use for the most updated, easy to read information on current trials?

    Thanks for your help. 
    Lisa

    Does anyone know of possible anti PD-1 trial openings for patients previously treated with IPI? 

    We are in Indianapolis so anywhere within an 8 hour drive would be best.

    What is the best link to use for the most updated, easy to read information on current trials?

    Thanks for your help. 
    Lisa

Viewing 23 reply threads
  • Replies
      • April 29, 2013 at 2:33 pm
      Fen
      Participant

      http://www.clinicaltrials.gov/

      I know you're looking for something more specific, but the search function on the site is pretty good.

      good luck!

      • April 29, 2013 at 2:33 pm
      Fen
      Participant

      http://www.clinicaltrials.gov/

      I know you're looking for something more specific, but the search function on the site is pretty good.

      good luck!

      • April 29, 2013 at 2:33 pm
      Fen
      Participant

      http://www.clinicaltrials.gov/

      I know you're looking for something more specific, but the search function on the site is pretty good.

      good luck!

      • April 29, 2013 at 2:52 pm
      kylez
      Participant

      Lisa, I discovered that this web site (MRF) has a very good clinical trial finder service — run by a third party, emergingMed. I tried it once and was very impressed with the quality and level of follow-up. You can enter your criteria or talk to them on the phone, then they will search for you and get back to you. They seemed very good at both the entrance criteria and sleuthing out trials — in my brief experience. See http://www.emergingmed.com/networks/MRF/

      Also, over on another site, MIF, Catherine Poole keeps very close tabs on different Anti-PD1 trials, through her contacts with clinicians and pharmas. For example see this posting, and contact info too, http://www.z2systems.com/mif/viewtopic.php?f=54&t=34105. 

      These are over and above clicking around on clinicaltrials.gov, I think both of the approaches above could be helpful supplements to your own research on, say, clinicaltrials.gov

      Good luck in your search — Kyle

      • April 29, 2013 at 2:52 pm
      kylez
      Participant

      Lisa, I discovered that this web site (MRF) has a very good clinical trial finder service — run by a third party, emergingMed. I tried it once and was very impressed with the quality and level of follow-up. You can enter your criteria or talk to them on the phone, then they will search for you and get back to you. They seemed very good at both the entrance criteria and sleuthing out trials — in my brief experience. See http://www.emergingmed.com/networks/MRF/

      Also, over on another site, MIF, Catherine Poole keeps very close tabs on different Anti-PD1 trials, through her contacts with clinicians and pharmas. For example see this posting, and contact info too, http://www.z2systems.com/mif/viewtopic.php?f=54&t=34105. 

      These are over and above clicking around on clinicaltrials.gov, I think both of the approaches above could be helpful supplements to your own research on, say, clinicaltrials.gov

      Good luck in your search — Kyle

      • April 29, 2013 at 2:52 pm
      kylez
      Participant

      Lisa, I discovered that this web site (MRF) has a very good clinical trial finder service — run by a third party, emergingMed. I tried it once and was very impressed with the quality and level of follow-up. You can enter your criteria or talk to them on the phone, then they will search for you and get back to you. They seemed very good at both the entrance criteria and sleuthing out trials — in my brief experience. See http://www.emergingmed.com/networks/MRF/

      Also, over on another site, MIF, Catherine Poole keeps very close tabs on different Anti-PD1 trials, through her contacts with clinicians and pharmas. For example see this posting, and contact info too, http://www.z2systems.com/mif/viewtopic.php?f=54&t=34105. 

      These are over and above clicking around on clinicaltrials.gov, I think both of the approaches above could be helpful supplements to your own research on, say, clinicaltrials.gov

      Good luck in your search — Kyle

      • April 29, 2013 at 6:41 pm
      Erinmay22
      Participant
      Most of the trials now are for those that failed ipi. I took ipi first and then started anti-pd1 at Sloan Kettering. I’m doing the phase 1 Merck. I have had 5 doses so far.

      Best of luck!

      • April 29, 2013 at 6:41 pm
      Erinmay22
      Participant
      Most of the trials now are for those that failed ipi. I took ipi first and then started anti-pd1 at Sloan Kettering. I’m doing the phase 1 Merck. I have had 5 doses so far.

      Best of luck!

      • April 29, 2013 at 6:41 pm
      Erinmay22
      Participant
      Most of the trials now are for those that failed ipi. I took ipi first and then started anti-pd1 at Sloan Kettering. I’m doing the phase 1 Merck. I have had 5 doses so far.

      Best of luck!

        • May 1, 2013 at 8:29 pm
        Jaryllane
        Participant

        Hi Erinmay. I am anticipating starting the Merck anti-PD1 trial in a few weeks.  Right now still waiting for tumor to get to 1cm so needle biopsy can be done.  Next scan on May 14.  I haven't had ipi or any other chemo for melanoma, just surgery for a lung tumor last July.  Can you please tell me what your experience with theMerck  trial drug has been so far?  How are you tolerating the drug?  Are you on a two-week or three-week cycle?  Are you experiencing side effects?

        Really appreciate any information you want to share.

         

        • May 1, 2013 at 8:29 pm
        Jaryllane
        Participant

        Hi Erinmay. I am anticipating starting the Merck anti-PD1 trial in a few weeks.  Right now still waiting for tumor to get to 1cm so needle biopsy can be done.  Next scan on May 14.  I haven't had ipi or any other chemo for melanoma, just surgery for a lung tumor last July.  Can you please tell me what your experience with theMerck  trial drug has been so far?  How are you tolerating the drug?  Are you on a two-week or three-week cycle?  Are you experiencing side effects?

        Really appreciate any information you want to share.

         

        • May 1, 2013 at 8:29 pm
        Jaryllane
        Participant

        Hi Erinmay. I am anticipating starting the Merck anti-PD1 trial in a few weeks.  Right now still waiting for tumor to get to 1cm so needle biopsy can be done.  Next scan on May 14.  I haven't had ipi or any other chemo for melanoma, just surgery for a lung tumor last July.  Can you please tell me what your experience with theMerck  trial drug has been so far?  How are you tolerating the drug?  Are you on a two-week or three-week cycle?  Are you experiencing side effects?

        Really appreciate any information you want to share.

         

      • April 29, 2013 at 7:53 pm
      bblapril
      Participant

      I know this is far to travel however my husband is on the trial at The Angeles Clinic in Los Angeles and the Dr. recently told us they are acccepting patients for the AntiPD1 trial….it is always worth a call!

      The Angeles Clinic Dr. Omid Hamid 310-231-2121

      • April 29, 2013 at 7:53 pm
      bblapril
      Participant

      I know this is far to travel however my husband is on the trial at The Angeles Clinic in Los Angeles and the Dr. recently told us they are acccepting patients for the AntiPD1 trial….it is always worth a call!

      The Angeles Clinic Dr. Omid Hamid 310-231-2121

      • April 29, 2013 at 7:53 pm
      bblapril
      Participant

      I know this is far to travel however my husband is on the trial at The Angeles Clinic in Los Angeles and the Dr. recently told us they are acccepting patients for the AntiPD1 trial….it is always worth a call!

      The Angeles Clinic Dr. Omid Hamid 310-231-2121

      • April 30, 2013 at 1:08 am
      lrkg1234
      Participant

      Thanks everyone.  So helpful!

      Well there was progress today.  He has an appointment set now at MD Anderson the 9th for the official big scans, brain & body after the IPI.  Then we will see what they have to offer.

      On the 29th we go see Dr. Puzanov again at Vanderbilt.  I learned a lot from everyone here and the research nurse at Vanderbilt about what was needed for the trials. 

      1.   No brain mets for a month. 

      2.  No temodor for a month.

      3.  No IPI for 6 weeks. 

      4.  Progression of disease after 6 week IPI scan. 

      Hopefull me posting this can help someone else. Good to know.  Now we wait and see what the scans bring.

      Lisa

      • April 30, 2013 at 1:08 am
      lrkg1234
      Participant

      Thanks everyone.  So helpful!

      Well there was progress today.  He has an appointment set now at MD Anderson the 9th for the official big scans, brain & body after the IPI.  Then we will see what they have to offer.

      On the 29th we go see Dr. Puzanov again at Vanderbilt.  I learned a lot from everyone here and the research nurse at Vanderbilt about what was needed for the trials. 

      1.   No brain mets for a month. 

      2.  No temodor for a month.

      3.  No IPI for 6 weeks. 

      4.  Progression of disease after 6 week IPI scan. 

      Hopefull me posting this can help someone else. Good to know.  Now we wait and see what the scans bring.

      Lisa

      • April 30, 2013 at 1:08 am
      lrkg1234
      Participant

      Thanks everyone.  So helpful!

      Well there was progress today.  He has an appointment set now at MD Anderson the 9th for the official big scans, brain & body after the IPI.  Then we will see what they have to offer.

      On the 29th we go see Dr. Puzanov again at Vanderbilt.  I learned a lot from everyone here and the research nurse at Vanderbilt about what was needed for the trials. 

      1.   No brain mets for a month. 

      2.  No temodor for a month.

      3.  No IPI for 6 weeks. 

      4.  Progression of disease after 6 week IPI scan. 

      Hopefull me posting this can help someone else. Good to know.  Now we wait and see what the scans bring.

      Lisa

      • May 1, 2013 at 1:51 am
      audgator
      Participant

      Lisa, I failed ipi & I'm on the anti-PD1 trial at Moffitt in Tampa.

      Dan

      • May 1, 2013 at 1:51 am
      audgator
      Participant

      Lisa, I failed ipi & I'm on the anti-PD1 trial at Moffitt in Tampa.

      Dan

      • May 1, 2013 at 1:51 am
      audgator
      Participant

      Lisa, I failed ipi & I'm on the anti-PD1 trial at Moffitt in Tampa.

      Dan

        • May 1, 2013 at 4:06 pm
        lsv12
        Participant

        Dan,

         Hi, my name is Lois Velardi, my husband also undergoes treatment at Moffitt.  We have been going since Jan 2012. My husband started on the trial for Zelboraf which stopped working after 9 months.  He was then placed on the ipi trial this past Jan. and like you nothing showed shrinkage after 4 doses.  They have now recommended the anti-PD1 trial. We are unsure of the what to do .  Your results are however reassuring.  The trial does have randomization with chemo. Is this the trial you are on?  

        • May 1, 2013 at 4:06 pm
        lsv12
        Participant

        Dan,

         Hi, my name is Lois Velardi, my husband also undergoes treatment at Moffitt.  We have been going since Jan 2012. My husband started on the trial for Zelboraf which stopped working after 9 months.  He was then placed on the ipi trial this past Jan. and like you nothing showed shrinkage after 4 doses.  They have now recommended the anti-PD1 trial. We are unsure of the what to do .  Your results are however reassuring.  The trial does have randomization with chemo. Is this the trial you are on?  

        • May 1, 2013 at 4:06 pm
        lsv12
        Participant

        Dan,

         Hi, my name is Lois Velardi, my husband also undergoes treatment at Moffitt.  We have been going since Jan 2012. My husband started on the trial for Zelboraf which stopped working after 9 months.  He was then placed on the ipi trial this past Jan. and like you nothing showed shrinkage after 4 doses.  They have now recommended the anti-PD1 trial. We are unsure of the what to do .  Your results are however reassuring.  The trial does have randomization with chemo. Is this the trial you are on?  

      • May 24, 2013 at 4:05 am
      chrisannca
      Participant

      Hi Lisa:

      PD-1 Antibody – Phase I Study of Single Agent MK-3475 in Patients with Progressive Locally Advanced or Metastatic Carcinomas and Melanoma is now open.

      http://clinicaltrials.gov/ct2/show/NCT01295827

      Unfortunately nothing is showing up in the Midwest.

      I was treated with IPI and Braf and am now consenting for the above clinical trial in Los Angeles.

      I lived in Indianapolis from 1976 to 1995…college at Ball State.

      I hope you have found a good treatment.  Stay in touch.

      This drug is worth traveling for…..

      ChrisAnn

      chrisann@richards-stark.com

      • May 24, 2013 at 4:05 am
      chrisannca
      Participant

      Hi Lisa:

      PD-1 Antibody – Phase I Study of Single Agent MK-3475 in Patients with Progressive Locally Advanced or Metastatic Carcinomas and Melanoma is now open.

      http://clinicaltrials.gov/ct2/show/NCT01295827

      Unfortunately nothing is showing up in the Midwest.

      I was treated with IPI and Braf and am now consenting for the above clinical trial in Los Angeles.

      I lived in Indianapolis from 1976 to 1995…college at Ball State.

      I hope you have found a good treatment.  Stay in touch.

      This drug is worth traveling for…..

      ChrisAnn

      chrisann@richards-stark.com

      • May 24, 2013 at 4:05 am
      chrisannca
      Participant

      Hi Lisa:

      PD-1 Antibody – Phase I Study of Single Agent MK-3475 in Patients with Progressive Locally Advanced or Metastatic Carcinomas and Melanoma is now open.

      http://clinicaltrials.gov/ct2/show/NCT01295827

      Unfortunately nothing is showing up in the Midwest.

      I was treated with IPI and Braf and am now consenting for the above clinical trial in Los Angeles.

      I lived in Indianapolis from 1976 to 1995…college at Ball State.

      I hope you have found a good treatment.  Stay in touch.

      This drug is worth traveling for…..

      ChrisAnn

      chrisann@richards-stark.com

      • May 24, 2013 at 4:07 am
      chrisannca
      Participant

      Hi Lisa:

      PD-1 Antibody – Phase I Study of Single Agent MK-3475 in Patients with Progressive Locally Advanced or Metastatic Carcinomas and Melanoma is now open.

      http://clinicaltrials.gov/ct2/show/NCT01295827

      Unfortunately nothing is showing up in the Midwest.

      I was treated with IPI and Braf and am now consenting for the above clinical trial in Los Angeles.

      I lived in Indianapolis from 1976 to 1995…college at Ball State.

      I hope you have found a good treatment.  Stay in touch.

      This drug is worth traveling for…..

      ChrisAnn

      chrisann@richards-stark.com

      • May 24, 2013 at 4:07 am
      chrisannca
      Participant

      Hi Lisa:

      PD-1 Antibody – Phase I Study of Single Agent MK-3475 in Patients with Progressive Locally Advanced or Metastatic Carcinomas and Melanoma is now open.

      http://clinicaltrials.gov/ct2/show/NCT01295827

      Unfortunately nothing is showing up in the Midwest.

      I was treated with IPI and Braf and am now consenting for the above clinical trial in Los Angeles.

      I lived in Indianapolis from 1976 to 1995…college at Ball State.

      I hope you have found a good treatment.  Stay in touch.

      This drug is worth traveling for…..

      ChrisAnn

      chrisann@richards-stark.com

      • May 24, 2013 at 4:07 am
      chrisannca
      Participant

      Hi Lisa:

      PD-1 Antibody – Phase I Study of Single Agent MK-3475 in Patients with Progressive Locally Advanced or Metastatic Carcinomas and Melanoma is now open.

      http://clinicaltrials.gov/ct2/show/NCT01295827

      Unfortunately nothing is showing up in the Midwest.

      I was treated with IPI and Braf and am now consenting for the above clinical trial in Los Angeles.

      I lived in Indianapolis from 1976 to 1995…college at Ball State.

      I hope you have found a good treatment.  Stay in touch.

      This drug is worth traveling for…..

      ChrisAnn

      chrisann@richards-stark.com

Viewing 23 reply threads
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