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Anti-pd-1 and bilirubin and alkaline phospate levels.
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Anti-pd-1 and bilirubin and alkaline phospate levels.

› Forums › General Melanoma Community › Anti-pd-1 and bilirubin and alkaline phospate levels.

  • Post
    • January 1, 2013 at 4:05 pm
    margaretrogers57
    Participant

      Just had blood work and 5th infusion of anti-pd-1.  This time the bilirubin had gone up to 1.3 previously .6  and alkaline phospate had gone up from 195 to 225.  Has anyone had this happen and does it mean the drugs aren't working.  HELP  Margaret

      Just had blood work and 5th infusion of anti-pd-1.  This time the bilirubin had gone up to 1.3 previously .6  and alkaline phospate had gone up from 195 to 225.  Has anyone had this happen and does it mean the drugs aren't working.  HELP  Margaret

    Viewing 2 reply threads
    • Replies
        • January 1, 2013 at 5:51 pm
        lak
        Participant

          Rising bilirubin and alk phos levels suggest a problem in the liver. It suggest an obstruction to the flow of bile at some point. This could be intra cellular or at some point of the biliary system- bile ducts gall bladder , billary tree etc. This could be stones in gallbladder or gile duct , or something obstructing the bile duct externally – a mass could be in common bile duct bile duct or within the liver causing a large branch of bile duct to be occluded.

          Some drugs can cause a cholestatic( where bile is stopped from flowing) problem but i have not heard of it from PD1. More tests will be required to deternine the cause

          What have your doctors told you?

           

          Lesley

            • January 2, 2013 at 12:23 am
            margaretrogers57
            Participant

              He doesn't feel any worse.  Dr. weber want to see what the numbers look like next wed.  Margaret

              • January 2, 2013 at 12:23 am
              margaretrogers57
              Participant

                He doesn't feel any worse.  Dr. weber want to see what the numbers look like next wed.  Margaret

                • January 2, 2013 at 12:23 am
                margaretrogers57
                Participant

                  He doesn't feel any worse.  Dr. weber want to see what the numbers look like next wed.  Margaret

                • January 1, 2013 at 5:51 pm
                lak
                Participant

                  Rising bilirubin and alk phos levels suggest a problem in the liver. It suggest an obstruction to the flow of bile at some point. This could be intra cellular or at some point of the biliary system- bile ducts gall bladder , billary tree etc. This could be stones in gallbladder or gile duct , or something obstructing the bile duct externally – a mass could be in common bile duct bile duct or within the liver causing a large branch of bile duct to be occluded.

                  Some drugs can cause a cholestatic( where bile is stopped from flowing) problem but i have not heard of it from PD1. More tests will be required to deternine the cause

                  What have your doctors told you?

                   

                  Lesley

                  • January 1, 2013 at 5:51 pm
                  lak
                  Participant

                    Rising bilirubin and alk phos levels suggest a problem in the liver. It suggest an obstruction to the flow of bile at some point. This could be intra cellular or at some point of the biliary system- bile ducts gall bladder , billary tree etc. This could be stones in gallbladder or gile duct , or something obstructing the bile duct externally – a mass could be in common bile duct bile duct or within the liver causing a large branch of bile duct to be occluded.

                    Some drugs can cause a cholestatic( where bile is stopped from flowing) problem but i have not heard of it from PD1. More tests will be required to deternine the cause

                    What have your doctors told you?

                     

                    Lesley

                Viewing 2 reply threads
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