Sorry your are dealing with this, Billy!! I know this is no fun to contemplate in any way!!! Still, I am going to hold onto hope that this is not mel and some sort of benign cyst. Something that can certainly happen fairly frequently to livers. However, it sounds like you are planning all the right things. First, a biopsy to see what you are really dealing with and then treatment as needed.
I may have shared it with you before but here is a primer of basic treatment for melanoma that covers a lot of options: https://chaoticallypreciselifeloveandmelanoma.blogspot.com/2017/08/melanoma-intel-primer-for-current.html
Additionally, to the repeating of nivo and adding ipi….Weber in a video linked to the discussion of "when to stop immunos" below….notes that folks who do progress after immunotherapy, often do really well when they repeat it and you would not only be repeating nivo, but adding another component in the ipi. Here is my report on that same video, which though the topic is when to stop treatment, does address your issue of needing to (?) repeat treatment:
https://chaoticallypreciselifeloveandmelanoma.blogspot.com/2017/08/melanoma-intel-primer-for-current.html
And a final thought…if I were in your shoes….and this turns out to really be melanoma…I would be asking about adding radiation to the immunotherapy. TONS of studies illustrate the added benefit when the two are combined. When combined (in the brain and body) radiation and immunotherapy provide results that are greater than either alone. Here are about a zillion posts:
https://chaoticallypreciselifeloveandmelanoma.blogspot.com/2018/11/srs-and-immunotherapy-in-melanoma-brain.html
Hang in there. Keep us posted. Fingers crossed that the biopsy is benign. Yours, celeste
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