MK-3475 Approval?
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MK-3475 Approval?

› Forums › General Melanoma Community › MK-3475 Approval?

  • Post
    • June 23, 2014 at 1:05 pm
    Scuba Doc
    Participant

    Rumor from a reliable source says MK-3475 (pembrolizumab) could be approved as early as mid summer. 

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  • Replies
      • June 23, 2014 at 2:01 pm
      rosa1
      Participant

      Does this source also mention any restrictions, such as prior IPI fail and/or BRAF therapies if BRAF positive?

      • June 23, 2014 at 2:01 pm
      rosa1
      Participant

      Does this source also mention any restrictions, such as prior IPI fail and/or BRAF therapies if BRAF positive?

        • June 23, 2014 at 2:27 pm
        Scuba Doc
        Participant

        He did not give any more info. — but I research those  questions daily — I hope the individual oncologist can make that decision.

        • June 23, 2014 at 2:27 pm
        Scuba Doc
        Participant

        He did not give any more info. — but I research those  questions daily — I hope the individual oncologist can make that decision.

        • June 23, 2014 at 2:27 pm
        Scuba Doc
        Participant

        He did not give any more info. — but I research those  questions daily — I hope the individual oncologist can make that decision.

        • June 23, 2014 at 2:49 pm
        RJoeyB
        Participant

        Catherine Poole at MIF has been trying to gather information from her contacts about this and put up a post this morning with some information here:

        http://forum.melanomainternational.org/mif/viewtopic.php?f=54&t=35124

         

        • June 23, 2014 at 2:49 pm
        RJoeyB
        Participant

        Catherine Poole at MIF has been trying to gather information from her contacts about this and put up a post this morning with some information here:

        http://forum.melanomainternational.org/mif/viewtopic.php?f=54&t=35124

         

        • June 23, 2014 at 4:20 pm
        Scuba Doc
        Participant

        On a more favorable note — When looking at this report, it looks like patients who are  IPI untreated do better that IPI treated patients when given pembrolizumab —– 

        http://www.businesswire.com/news/home/20140602005550/en/Data-Merck%E2%80%99s-Pembrolizumab-Largest-Study-Date-Investigational#.U6hSSZt15w5

        • June 23, 2014 at 4:20 pm
        Scuba Doc
        Participant

        On a more favorable note — When looking at this report, it looks like patients who are  IPI untreated do better that IPI treated patients when given pembrolizumab —– 

        http://www.businesswire.com/news/home/20140602005550/en/Data-Merck%E2%80%99s-Pembrolizumab-Largest-Study-Date-Investigational#.U6hSSZt15w5

        • June 23, 2014 at 5:50 pm
        KatB
        Participant

        Favorable for some, I suppose…

        • June 23, 2014 at 5:50 pm
        KatB
        Participant

        Favorable for some, I suppose…

        • June 24, 2014 at 8:50 pm
        Cooper
        Participant

        How is that favorable if they require you to have IPI before you can get PD1!

        • June 24, 2014 at 8:50 pm
        Cooper
        Participant

        How is that favorable if they require you to have IPI before you can get PD1!

        • June 25, 2014 at 11:26 am
        Scuba Doc
        Participant

        Perhaps with all the new test results Merck will allow melanoma patients to take pembrolizumab regardless of having been previously treated with IPI. I know that some patients opted not to take the IPI for other health reasons. Allowing those patients access to pembrolizumab seem like a no brainer based on the current data.

        • June 25, 2014 at 11:26 am
        Scuba Doc
        Participant

        Perhaps with all the new test results Merck will allow melanoma patients to take pembrolizumab regardless of having been previously treated with IPI. I know that some patients opted not to take the IPI for other health reasons. Allowing those patients access to pembrolizumab seem like a no brainer based on the current data.

        • June 25, 2014 at 11:26 am
        Scuba Doc
        Participant

        Perhaps with all the new test results Merck will allow melanoma patients to take pembrolizumab regardless of having been previously treated with IPI. I know that some patients opted not to take the IPI for other health reasons. Allowing those patients access to pembrolizumab seem like a no brainer based on the current data.

        • June 25, 2014 at 5:36 pm
        Cooper
        Participant

        It is up to the FDA to decide, be sure to write or call them or your congressman

        • June 25, 2014 at 5:36 pm
        Cooper
        Participant

        It is up to the FDA to decide, be sure to write or call them or your congressman

        • June 25, 2014 at 5:36 pm
        Cooper
        Participant

        It is up to the FDA to decide, be sure to write or call them or your congressman

        • June 24, 2014 at 8:50 pm
        Cooper
        Participant

        How is that favorable if they require you to have IPI before you can get PD1!

        • June 23, 2014 at 5:50 pm
        KatB
        Participant

        Favorable for some, I suppose…

        • June 23, 2014 at 4:20 pm
        Scuba Doc
        Participant

        On a more favorable note — When looking at this report, it looks like patients who are  IPI untreated do better that IPI treated patients when given pembrolizumab —– 

        http://www.businesswire.com/news/home/20140602005550/en/Data-Merck%E2%80%99s-Pembrolizumab-Largest-Study-Date-Investigational#.U6hSSZt15w5

        • June 23, 2014 at 2:49 pm
        RJoeyB
        Participant

        Catherine Poole at MIF has been trying to gather information from her contacts about this and put up a post this morning with some information here:

        http://forum.melanomainternational.org/mif/viewtopic.php?f=54&t=35124

         

      • June 23, 2014 at 2:01 pm
      rosa1
      Participant

      Does this source also mention any restrictions, such as prior IPI fail and/or BRAF therapies if BRAF positive?

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