Hepatotoxicity with Combination of Vemurafenib and Ipilimumab
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Hepatotoxicity with Combination of Vemurafenib and Ipilimumab

› Forums › General Melanoma Community › Hepatotoxicity with Combination of Vemurafenib and Ipilimumab

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      • April 8, 2013 at 12:03 pm
      POW
      Participant

      Thank you for posting this information. The last line of the report should be of particular interest to melanoma patients: "The results of this phase 1 study highlight the risk of concurrent administration of vemurafenib and ipilimumab. Our findings reinforce the need for carefully conducted trials of new combination therapies, even when both agents have regulatory approval and have distinct mechanisms of action."

      We are all sorely tempted to push for better and faster treatments and combining approved therapies seems to be a good way to do that. But going forward, we will have to wait patiently for clinical trials of such combnations because strange and unexpected things can happen. Sad but true.

        • April 8, 2013 at 7:06 pm
        awillett1991
        Participant
        We are still dealing with a disease with no cure and I believe we must pick the best doctors we can and with our own knowledge, use their advice and accept the risks. Many therapies are done with known highly toxic responses, such as HD IL2 or biochemo.

        Fortunately my liver recovered and I have no regrets. I think they are focusing trials on how to best sequence Ipi & Zel now.

        • April 9, 2013 at 3:11 am
        Bubbles
        Participant

        Hey Buddy!!

        Good intel. Thanks for posting.  It is a tricky business….how much you can do to a body to kill the melanoma (or cancer de jour) without doing irreparable damage to the body itself.  Obviously we have much to learn.  And…the only way to learn is through lab rats like me and the zillion others out there.  Bottom line…we need to have the say, the vote….regarding what we choose to try…in order to avoid the necessary (otherwise) result of our "untreatable"/"deadly" disease.  No melanoma…No vote. Granted this should be an informed choice, with the best data possible.  It seems to me that combination therapies…like this…in some form…will be the future treatment for those of us living with melanoma.  More poor ratties will have to be utilized to figure out the balance needed.  But…I think we will get there.

        Thanks. Hang tough, my friend.  C

        • April 9, 2013 at 3:11 am
        Bubbles
        Participant

        Hey Buddy!!

        Good intel. Thanks for posting.  It is a tricky business….how much you can do to a body to kill the melanoma (or cancer de jour) without doing irreparable damage to the body itself.  Obviously we have much to learn.  And…the only way to learn is through lab rats like me and the zillion others out there.  Bottom line…we need to have the say, the vote….regarding what we choose to try…in order to avoid the necessary (otherwise) result of our "untreatable"/"deadly" disease.  No melanoma…No vote. Granted this should be an informed choice, with the best data possible.  It seems to me that combination therapies…like this…in some form…will be the future treatment for those of us living with melanoma.  More poor ratties will have to be utilized to figure out the balance needed.  But…I think we will get there.

        Thanks. Hang tough, my friend.  C

        • April 10, 2013 at 10:13 pm
        gloria
        Participant

        So thankful there are willing "ratties" like you.  Thanks you from all of us.

        • April 10, 2013 at 10:13 pm
        gloria
        Participant

        So thankful there are willing "ratties" like you.  Thanks you from all of us.

        • April 10, 2013 at 10:13 pm
        gloria
        Participant

        So thankful there are willing "ratties" like you.  Thanks you from all of us.

        • April 10, 2013 at 10:14 pm
        gloria
        Participant

        So thankful there are willing "ratties" like you.  Thanks you from all of us.

        • April 10, 2013 at 10:14 pm
        gloria
        Participant

        So thankful there are willing "ratties" like you.  Thanks you from all of us.

        • April 10, 2013 at 10:14 pm
        gloria
        Participant

        So thankful there are willing "ratties" like you.  Thanks you from all of us.

        • April 9, 2013 at 3:11 am
        Bubbles
        Participant

        Hey Buddy!!

        Good intel. Thanks for posting.  It is a tricky business….how much you can do to a body to kill the melanoma (or cancer de jour) without doing irreparable damage to the body itself.  Obviously we have much to learn.  And…the only way to learn is through lab rats like me and the zillion others out there.  Bottom line…we need to have the say, the vote….regarding what we choose to try…in order to avoid the necessary (otherwise) result of our "untreatable"/"deadly" disease.  No melanoma…No vote. Granted this should be an informed choice, with the best data possible.  It seems to me that combination therapies…like this…in some form…will be the future treatment for those of us living with melanoma.  More poor ratties will have to be utilized to figure out the balance needed.  But…I think we will get there.

        Thanks. Hang tough, my friend.  C

        • April 8, 2013 at 7:06 pm
        awillett1991
        Participant
        We are still dealing with a disease with no cure and I believe we must pick the best doctors we can and with our own knowledge, use their advice and accept the risks. Many therapies are done with known highly toxic responses, such as HD IL2 or biochemo.

        Fortunately my liver recovered and I have no regrets. I think they are focusing trials on how to best sequence Ipi & Zel now.

        • April 8, 2013 at 7:06 pm
        awillett1991
        Participant
        We are still dealing with a disease with no cure and I believe we must pick the best doctors we can and with our own knowledge, use their advice and accept the risks. Many therapies are done with known highly toxic responses, such as HD IL2 or biochemo.

        Fortunately my liver recovered and I have no regrets. I think they are focusing trials on how to best sequence Ipi & Zel now.

      • April 8, 2013 at 12:03 pm
      POW
      Participant

      Thank you for posting this information. The last line of the report should be of particular interest to melanoma patients: "The results of this phase 1 study highlight the risk of concurrent administration of vemurafenib and ipilimumab. Our findings reinforce the need for carefully conducted trials of new combination therapies, even when both agents have regulatory approval and have distinct mechanisms of action."

      We are all sorely tempted to push for better and faster treatments and combining approved therapies seems to be a good way to do that. But going forward, we will have to wait patiently for clinical trials of such combnations because strange and unexpected things can happen. Sad but true.

      • April 8, 2013 at 12:03 pm
      POW
      Participant

      Thank you for posting this information. The last line of the report should be of particular interest to melanoma patients: "The results of this phase 1 study highlight the risk of concurrent administration of vemurafenib and ipilimumab. Our findings reinforce the need for carefully conducted trials of new combination therapies, even when both agents have regulatory approval and have distinct mechanisms of action."

      We are all sorely tempted to push for better and faster treatments and combining approved therapies seems to be a good way to do that. But going forward, we will have to wait patiently for clinical trials of such combnations because strange and unexpected things can happen. Sad but true.

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