Yervoy Dose?

3mg per kg.

I tolerated it but had to delay treatments

loose motions by 10 days after first dose. by 14th day going thru night to and went on steriods. Recovered by time second injection due. Loose motions again increase steroids, hepatitis at 2 weeks post dose higher steroids recoverd a delayed 3rd injection.

doses were 3rd sept 2010, 25th sept, 15 th oct final dose 22nd  Dec. I was getting it outside any trial and it wasnt licensed in Europe then. I had progressed by the second week of Dec but still wanted final dose. Scans in Feb showed further progression and I had SIRT 12 weeks after that last late dose. No new tumour since and all liver lesions cleared by SIRT.

Sept 2011  partial hypo pituitarism diagnosed. I take thyroxine.  My schedule was most unconventional and you couldnt have it that way now. I didnt get off steroids till Oct 2011.

Sept – end Nov I couldn t eat anything but dry cornflakes and white rice- I favored Jasmine rice!

I wish I could have had annual booster doses. But I dont think they will give it unless there is tumour.

Lesley

3mg per kg.

I tolerated it but had to delay treatments

loose motions by 10 days after first dose. by 14th day going thru night to and went on steriods. Recovered by time second injection due. Loose motions again increase steroids, hepatitis at 2 weeks post dose higher steroids recoverd a delayed 3rd injection.

doses were 3rd sept 2010, 25th sept, 15 th oct final dose 22nd  Dec. I was getting it outside any trial and it wasnt licensed in Europe then. I had progressed by the second week of Dec but still wanted final dose. Scans in Feb showed further progression and I had SIRT 12 weeks after that last late dose. No new tumour since and all liver lesions cleared by SIRT.

Sept 2011  partial hypo pituitarism diagnosed. I take thyroxine.  My schedule was most unconventional and you couldnt have it that way now. I didnt get off steroids till Oct 2011.

Sept – end Nov I couldn t eat anything but dry cornflakes and white rice- I favored Jasmine rice!

I wish I could have had annual booster doses. But I dont think they will give it unless there is tumour.

Lesley

3mg per kg.

I tolerated it but had to delay treatments

loose motions by 10 days after first dose. by 14th day going thru night to and went on steriods. Recovered by time second injection due. Loose motions again increase steroids, hepatitis at 2 weeks post dose higher steroids recoverd a delayed 3rd injection.

doses were 3rd sept 2010, 25th sept, 15 th oct final dose 22nd  Dec. I was getting it outside any trial and it wasnt licensed in Europe then. I had progressed by the second week of Dec but still wanted final dose. Scans in Feb showed further progression and I had SIRT 12 weeks after that last late dose. No new tumour since and all liver lesions cleared by SIRT.

Sept 2011  partial hypo pituitarism diagnosed. I take thyroxine.  My schedule was most unconventional and you couldnt have it that way now. I didnt get off steroids till Oct 2011.

Sept – end Nov I couldn t eat anything but dry cornflakes and white rice- I favored Jasmine rice!

I wish I could have had annual booster doses. But I dont think they will give it unless there is tumour.

Lesley

Hi SE,

I've had two courses of Ipi/Yervoy, first on the compassionate trial and I finished the second course June 25, 2012. The first course I had very little side effects… rash and slight diarrhea. Per the trial, I had scans one week after completing Ipi and it showed enlarged and 3 new lesions in liver (for total of 6) and several enlarged abdominal nodes as well as peritoneal and small lung nodules. Things settled back down and by April everything had reduced and I showed 4 nodules.

Due to an enlarging mass between stomach and spleen, I had Ipi re-induction, and between the first and second infusion, I had 4 cyberknife treatments to the mass. This time I did experience more severe diahrrea and was put on prednisone, this was after 3rd infusion. I tapered off of that, but then had elevated liver enzymes and was put back on steriods. I went 4 wks between 3rd & 4th infusion (as I attended symposium in Philly and didn't want to worry about dealing with things while traveling). I had my first scan 7 wks. after my June 25th infusion and it showed things the same as May (when I had CT to check cyberknife results……abdominal lesions and mass slightly larger, which I expected due to Ipi). Aug. scans showed stable since May with nothing NEW. I'm hoping Nov. scans show some reduction. All in all, I'm pretty much stable since April, 2011.

Hope this is helpful. Take care.

Nan

Dx- 2001

Liver Mets-2009

Hi SE,

I've had two courses of Ipi/Yervoy, first on the compassionate trial and I finished the second course June 25, 2012. The first course I had very little side effects… rash and slight diarrhea. Per the trial, I had scans one week after completing Ipi and it showed enlarged and 3 new lesions in liver (for total of 6) and several enlarged abdominal nodes as well as peritoneal and small lung nodules. Things settled back down and by April everything had reduced and I showed 4 nodules.

Due to an enlarging mass between stomach and spleen, I had Ipi re-induction, and between the first and second infusion, I had 4 cyberknife treatments to the mass. This time I did experience more severe diahrrea and was put on prednisone, this was after 3rd infusion. I tapered off of that, but then had elevated liver enzymes and was put back on steriods. I went 4 wks between 3rd & 4th infusion (as I attended symposium in Philly and didn't want to worry about dealing with things while traveling). I had my first scan 7 wks. after my June 25th infusion and it showed things the same as May (when I had CT to check cyberknife results……abdominal lesions and mass slightly larger, which I expected due to Ipi). Aug. scans showed stable since May with nothing NEW. I'm hoping Nov. scans show some reduction. All in all, I'm pretty much stable since April, 2011.

Hope this is helpful. Take care.

Nan

Dx- 2001

Liver Mets-2009

Hi SE,

I've had two courses of Ipi/Yervoy, first on the compassionate trial and I finished the second course June 25, 2012. The first course I had very little side effects… rash and slight diarrhea. Per the trial, I had scans one week after completing Ipi and it showed enlarged and 3 new lesions in liver (for total of 6) and several enlarged abdominal nodes as well as peritoneal and small lung nodules. Things settled back down and by April everything had reduced and I showed 4 nodules.

Due to an enlarging mass between stomach and spleen, I had Ipi re-induction, and between the first and second infusion, I had 4 cyberknife treatments to the mass. This time I did experience more severe diahrrea and was put on prednisone, this was after 3rd infusion. I tapered off of that, but then had elevated liver enzymes and was put back on steriods. I went 4 wks between 3rd & 4th infusion (as I attended symposium in Philly and didn't want to worry about dealing with things while traveling). I had my first scan 7 wks. after my June 25th infusion and it showed things the same as May (when I had CT to check cyberknife results……abdominal lesions and mass slightly larger, which I expected due to Ipi). Aug. scans showed stable since May with nothing NEW. I'm hoping Nov. scans show some reduction. All in all, I'm pretty much stable since April, 2011.

Hope this is helpful. Take care.

Nan

Dx- 2001

Liver Mets-2009