Zelboraf (vemurafenib) Resistance
REGISTER
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

Zelboraf (vemurafenib) Resistance

› Forums › General Melanoma Community › Zelboraf (vemurafenib) Resistance

  • Post
    • September 18, 2012 at 7:31 pm
    gofamily
    Participant

    My husband has stage 4 melanoma with metastasis to the liver. He was on Zelboraf which worked well until 1 month ago when a new tumor appeared and his liver tumor became active again on the PET scan. Does anyone know of clinical trials specifically for Zelboraf resistance?!

    My husband has stage 4 melanoma with metastasis to the liver. He was on Zelboraf which worked well until 1 month ago when a new tumor appeared and his liver tumor became active again on the PET scan. Does anyone know of clinical trials specifically for Zelboraf resistance?!

Viewing 5 reply threads
  • Replies
      • September 18, 2012 at 10:28 pm
      POW
      Participant

      I am sorry for this disapointing news you got. Unfortunately, Zelboraf only works in about 50% of the people who try it and even when it works, the melanoma becomes resistant to Z after several months. That is why they recently started a clinical trial with another anti-BRAF drug (Dabrafenib) plus an anti-MEK drug to see if a 1-2 punch would prevent resistance.  

      Meanwhile, I know of no clinical trials for people who became resistant to Zelboraf. Zelboraf never worked for my brother and his oncologist recommended he try Ipi. You might look into that.

      • September 18, 2012 at 10:28 pm
      POW
      Participant

      I am sorry for this disapointing news you got. Unfortunately, Zelboraf only works in about 50% of the people who try it and even when it works, the melanoma becomes resistant to Z after several months. That is why they recently started a clinical trial with another anti-BRAF drug (Dabrafenib) plus an anti-MEK drug to see if a 1-2 punch would prevent resistance.  

      Meanwhile, I know of no clinical trials for people who became resistant to Zelboraf. Zelboraf never worked for my brother and his oncologist recommended he try Ipi. You might look into that.

      • September 18, 2012 at 10:28 pm
      POW
      Participant

      I am sorry for this disapointing news you got. Unfortunately, Zelboraf only works in about 50% of the people who try it and even when it works, the melanoma becomes resistant to Z after several months. That is why they recently started a clinical trial with another anti-BRAF drug (Dabrafenib) plus an anti-MEK drug to see if a 1-2 punch would prevent resistance.  

      Meanwhile, I know of no clinical trials for people who became resistant to Zelboraf. Zelboraf never worked for my brother and his oncologist recommended he try Ipi. You might look into that.

      • September 19, 2012 at 4:19 pm
      awillett1991
      Participant
      If you had a profile with info, it would be much easier to understand your situation and offer help. I am stopping Zel to start Ipi. It hasn’t failed me yet but my onc says we would’ve done it either way. Been on 5 mos.
      • September 19, 2012 at 4:19 pm
      awillett1991
      Participant
      If you had a profile with info, it would be much easier to understand your situation and offer help. I am stopping Zel to start Ipi. It hasn’t failed me yet but my onc says we would’ve done it either way. Been on 5 mos.
      • September 19, 2012 at 4:19 pm
      awillett1991
      Participant
      If you had a profile with info, it would be much easier to understand your situation and offer help. I am stopping Zel to start Ipi. It hasn’t failed me yet but my onc says we would’ve done it either way. Been on 5 mos.
Viewing 5 reply threads
  • You must be logged in to reply to this topic.
About the MRF Patient Forum

The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.

Popular Topics