TIL then Ipi? Vice-versa?
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TIL then Ipi? Vice-versa?

› Forums › General Melanoma Community › TIL then Ipi? Vice-versa?

  • Post
    • May 2, 2012 at 12:59 am
    benp
    Participant
    Does anyone know if there is an optiomal ordering of these two therapies?

    Does anyone know if there is an optiomal ordering of these two therapies?

Viewing 11 reply threads
  • Replies
      • May 2, 2012 at 1:44 am
      jag
      Participant

      Definitely IPI first.  Since I have watched on this board (2003)  I have not seen one person survive with just TLI, IPI on the other hand has been approved by the FDA for treatment.  IPI has shown survival results.  TLI reengineers the immmune system and if it doesn't work, it may actually damage the immune system.  Again IPI shows increased long term survival benefits and acts to boost your immune system.  TLI can actually harm it.  I don't know why it even exists anymore.

        • May 2, 2012 at 5:34 am
        benp
        Participant
        Thanks for the reply, but are we talking about the same thing? I am referring to Tumor Infiltrating Lymphocytes (or ACT). It also shows long term survival benefit.
        • May 2, 2012 at 5:34 am
        benp
        Participant
        Thanks for the reply, but are we talking about the same thing? I am referring to Tumor Infiltrating Lymphocytes (or ACT). It also shows long term survival benefit.
        • May 2, 2012 at 5:34 am
        benp
        Participant
        Thanks for the reply, but are we talking about the same thing? I am referring to Tumor Infiltrating Lymphocytes (or ACT). It also shows long term survival benefit.
      • May 2, 2012 at 1:44 am
      jag
      Participant

      Definitely IPI first.  Since I have watched on this board (2003)  I have not seen one person survive with just TLI, IPI on the other hand has been approved by the FDA for treatment.  IPI has shown survival results.  TLI reengineers the immmune system and if it doesn't work, it may actually damage the immune system.  Again IPI shows increased long term survival benefits and acts to boost your immune system.  TLI can actually harm it.  I don't know why it even exists anymore.

      • May 2, 2012 at 1:44 am
      jag
      Participant

      Definitely IPI first.  Since I have watched on this board (2003)  I have not seen one person survive with just TLI, IPI on the other hand has been approved by the FDA for treatment.  IPI has shown survival results.  TLI reengineers the immmune system and if it doesn't work, it may actually damage the immune system.  Again IPI shows increased long term survival benefits and acts to boost your immune system.  TLI can actually harm it.  I don't know why it even exists anymore.

      • May 2, 2012 at 12:21 pm
      jim Breitfeller
      Participant

      Ben, The two therapies uses tow different approaches to the immune system.

      Ipi: Acts on the CTLA-4 receptors, on the Tregs and the T-cells which help stop the Treg suppression of T-cell Activation.

      The TIL or Act therapy uses your activated CD8+ T-cells. The Tregs are depleted/supressed prior to the TIL therapy using Chemo drugs.

      Your best bet is to use these two therapy in combination, if there is a trial available.

       

      Best regards,

      Jimmy B

        • May 7, 2012 at 10:22 am
        benp
        Participant

        Thanks Jim! I just wish I did have the luxury to choose at the moment.

        • May 7, 2012 at 10:22 am
        benp
        Participant

        Thanks Jim! I just wish I did have the luxury to choose at the moment.

        • May 7, 2012 at 10:22 am
        benp
        Participant

        Thanks Jim! I just wish I did have the luxury to choose at the moment.

      • May 2, 2012 at 12:21 pm
      jim Breitfeller
      Participant

      Ben, The two therapies uses tow different approaches to the immune system.

      Ipi: Acts on the CTLA-4 receptors, on the Tregs and the T-cells which help stop the Treg suppression of T-cell Activation.

      The TIL or Act therapy uses your activated CD8+ T-cells. The Tregs are depleted/supressed prior to the TIL therapy using Chemo drugs.

      Your best bet is to use these two therapy in combination, if there is a trial available.

       

      Best regards,

      Jimmy B

      • May 2, 2012 at 12:21 pm
      jim Breitfeller
      Participant

      Ben, The two therapies uses tow different approaches to the immune system.

      Ipi: Acts on the CTLA-4 receptors, on the Tregs and the T-cells which help stop the Treg suppression of T-cell Activation.

      The TIL or Act therapy uses your activated CD8+ T-cells. The Tregs are depleted/supressed prior to the TIL therapy using Chemo drugs.

      Your best bet is to use these two therapy in combination, if there is a trial available.

       

      Best regards,

      Jimmy B

      • May 3, 2012 at 4:41 pm
      EmilyandMike
      Participant

      Hello – please try and read this article "The T-Cell Army"  – I had to have my dad copy it and mail to me because I am not a subscriber and this link is just an abstract  http://www.newyorker.com/reporting/2012/04/23/120423fa_fact_groopman 

      It is a wonderful article.  The article explains Yervoy and TIL – and the docs say the people who have had TIL after Yervoy had better results.

      So Yervoy first is what this very well written article says…

      Take care

      Emily

      • May 3, 2012 at 4:41 pm
      EmilyandMike
      Participant

      Hello – please try and read this article "The T-Cell Army"  – I had to have my dad copy it and mail to me because I am not a subscriber and this link is just an abstract  http://www.newyorker.com/reporting/2012/04/23/120423fa_fact_groopman 

      It is a wonderful article.  The article explains Yervoy and TIL – and the docs say the people who have had TIL after Yervoy had better results.

      So Yervoy first is what this very well written article says…

      Take care

      Emily

        • May 3, 2012 at 5:07 pm
        EmilyandMike
        Participant

        I am actually going to purchase this New Yorker article so I can send it to a couple of people so email me if you want a copy – emily@emandmichael.com

        • May 3, 2012 at 5:07 pm
        EmilyandMike
        Participant

        I am actually going to purchase this New Yorker article so I can send it to a couple of people so email me if you want a copy – emily@emandmichael.com

        • May 7, 2012 at 10:20 am
        benp
        Participant

        Thanks a lot for reminding me of this! I read the excerpt. I would love a copy of the article if you've got it – ben_perdriau @ hotmail.com.

         

        Thanks!

        Ben.

        • May 7, 2012 at 10:20 am
        benp
        Participant

        Thanks a lot for reminding me of this! I read the excerpt. I would love a copy of the article if you've got it – ben_perdriau @ hotmail.com.

         

        Thanks!

        Ben.

        • May 7, 2012 at 10:20 am
        benp
        Participant

        Thanks a lot for reminding me of this! I read the excerpt. I would love a copy of the article if you've got it – ben_perdriau @ hotmail.com.

         

        Thanks!

        Ben.

        • May 3, 2012 at 5:07 pm
        EmilyandMike
        Participant

        I am actually going to purchase this New Yorker article so I can send it to a couple of people so email me if you want a copy – emily@emandmichael.com

      • May 3, 2012 at 4:41 pm
      EmilyandMike
      Participant

      Hello – please try and read this article "The T-Cell Army"  – I had to have my dad copy it and mail to me because I am not a subscriber and this link is just an abstract  http://www.newyorker.com/reporting/2012/04/23/120423fa_fact_groopman 

      It is a wonderful article.  The article explains Yervoy and TIL – and the docs say the people who have had TIL after Yervoy had better results.

      So Yervoy first is what this very well written article says…

      Take care

      Emily

      • May 14, 2012 at 11:23 pm
      maryv
      Participant

      Hi,

      I am new to this forum.  My mum has stage V (lg mass in abdominal cavity, lymph nodes).  IL-2 did not work.  She is exploring trials. Her current oncologist was about to start her on Ipi alone as they don't have any other trials right now that suit her.  We just want to make sure we're not excluding her from any trials by starting it, so this sequencing discussion is of interest.

      She has a meeting with Dr. Rosenberg's team to talk about ACT, and has been identified as a candidate for a trial at DFCI with PD-L1 and Ipi.  We heard that while she doesn't have brain mets and is otherwise healthy, this is a good time to try ACT, and that she can do Ipi afterwards, but that Ipi would exclude her from ACT.

      Thoughts welcome.

      Thanks.

      Maryv

      • May 14, 2012 at 11:23 pm
      maryv
      Participant

      Hi,

      I am new to this forum.  My mum has stage V (lg mass in abdominal cavity, lymph nodes).  IL-2 did not work.  She is exploring trials. Her current oncologist was about to start her on Ipi alone as they don't have any other trials right now that suit her.  We just want to make sure we're not excluding her from any trials by starting it, so this sequencing discussion is of interest.

      She has a meeting with Dr. Rosenberg's team to talk about ACT, and has been identified as a candidate for a trial at DFCI with PD-L1 and Ipi.  We heard that while she doesn't have brain mets and is otherwise healthy, this is a good time to try ACT, and that she can do Ipi afterwards, but that Ipi would exclude her from ACT.

      Thoughts welcome.

      Thanks.

      Maryv

      • May 14, 2012 at 11:23 pm
      maryv
      Participant

      Hi,

      I am new to this forum.  My mum has stage V (lg mass in abdominal cavity, lymph nodes).  IL-2 did not work.  She is exploring trials. Her current oncologist was about to start her on Ipi alone as they don't have any other trials right now that suit her.  We just want to make sure we're not excluding her from any trials by starting it, so this sequencing discussion is of interest.

      She has a meeting with Dr. Rosenberg's team to talk about ACT, and has been identified as a candidate for a trial at DFCI with PD-L1 and Ipi.  We heard that while she doesn't have brain mets and is otherwise healthy, this is a good time to try ACT, and that she can do Ipi afterwards, but that Ipi would exclude her from ACT.

      Thoughts welcome.

      Thanks.

      Maryv

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