TIL then Ipi? Vice-versa?

Definitely IPI first.  Since I have watched on this board (2003)  I have not seen one person survive with just TLI, IPI on the other hand has been approved by the FDA for treatment.  IPI has shown survival results.  TLI reengineers the immmune system and if it doesn't work, it may actually damage the immune system.  Again IPI shows increased long term survival benefits and acts to boost your immune system.  TLI can actually harm it.  I don't know why it even exists anymore.

Definitely IPI first.  Since I have watched on this board (2003)  I have not seen one person survive with just TLI, IPI on the other hand has been approved by the FDA for treatment.  IPI has shown survival results.  TLI reengineers the immmune system and if it doesn't work, it may actually damage the immune system.  Again IPI shows increased long term survival benefits and acts to boost your immune system.  TLI can actually harm it.  I don't know why it even exists anymore.

Definitely IPI first.  Since I have watched on this board (2003)  I have not seen one person survive with just TLI, IPI on the other hand has been approved by the FDA for treatment.  IPI has shown survival results.  TLI reengineers the immmune system and if it doesn't work, it may actually damage the immune system.  Again IPI shows increased long term survival benefits and acts to boost your immune system.  TLI can actually harm it.  I don't know why it even exists anymore.

Ben, The two therapies uses tow different approaches to the immune system.

Ipi: Acts on the CTLA-4 receptors, on the Tregs and the T-cells which help stop the Treg suppression of T-cell Activation.

The TIL or Act therapy uses your activated CD8+ T-cells. The Tregs are depleted/supressed prior to the TIL therapy using Chemo drugs.

Your best bet is to use these two therapy in combination, if there is a trial available.

Best regards,

Jimmy B

Ben, The two therapies uses tow different approaches to the immune system.

Ipi: Acts on the CTLA-4 receptors, on the Tregs and the T-cells which help stop the Treg suppression of T-cell Activation.

The TIL or Act therapy uses your activated CD8+ T-cells. The Tregs are depleted/supressed prior to the TIL therapy using Chemo drugs.

Your best bet is to use these two therapy in combination, if there is a trial available.

Best regards,

Jimmy B

Ben, The two therapies uses tow different approaches to the immune system.

Ipi: Acts on the CTLA-4 receptors, on the Tregs and the T-cells which help stop the Treg suppression of T-cell Activation.

The TIL or Act therapy uses your activated CD8+ T-cells. The Tregs are depleted/supressed prior to the TIL therapy using Chemo drugs.

Your best bet is to use these two therapy in combination, if there is a trial available.

Best regards,

Jimmy B

Hello – please try and read this article "The T-Cell Army"  – I had to have my dad copy it and mail to me because I am not a subscriber and this link is just an abstract  http://www.newyorker.com/reporting/2012/04/23/120423fa_fact_groopman 

It is a wonderful article.  The article explains Yervoy and TIL – and the docs say the people who have had TIL after Yervoy had better results.

So Yervoy first is what this very well written article says…

Take care

Emily

Hello – please try and read this article "The T-Cell Army"  – I had to have my dad copy it and mail to me because I am not a subscriber and this link is just an abstract  http://www.newyorker.com/reporting/2012/04/23/120423fa_fact_groopman 

It is a wonderful article.  The article explains Yervoy and TIL – and the docs say the people who have had TIL after Yervoy had better results.

So Yervoy first is what this very well written article says…

Take care

Emily

Hello – please try and read this article "The T-Cell Army"  – I had to have my dad copy it and mail to me because I am not a subscriber and this link is just an abstract  http://www.newyorker.com/reporting/2012/04/23/120423fa_fact_groopman 

It is a wonderful article.  The article explains Yervoy and TIL – and the docs say the people who have had TIL after Yervoy had better results.

So Yervoy first is what this very well written article says…

Take care

Emily

Hi,

I am new to this forum.  My mum has stage V (lg mass in abdominal cavity, lymph nodes).  IL-2 did not work.  She is exploring trials. Her current oncologist was about to start her on Ipi alone as they don't have any other trials right now that suit her.  We just want to make sure we're not excluding her from any trials by starting it, so this sequencing discussion is of interest.

She has a meeting with Dr. Rosenberg's team to talk about ACT, and has been identified as a candidate for a trial at DFCI with PD-L1 and Ipi.  We heard that while she doesn't have brain mets and is otherwise healthy, this is a good time to try ACT, and that she can do Ipi afterwards, but that Ipi would exclude her from ACT.

Thoughts welcome.

Thanks.

Maryv

Hi,

I am new to this forum.  My mum has stage V (lg mass in abdominal cavity, lymph nodes).  IL-2 did not work.  She is exploring trials. Her current oncologist was about to start her on Ipi alone as they don't have any other trials right now that suit her.  We just want to make sure we're not excluding her from any trials by starting it, so this sequencing discussion is of interest.

She has a meeting with Dr. Rosenberg's team to talk about ACT, and has been identified as a candidate for a trial at DFCI with PD-L1 and Ipi.  We heard that while she doesn't have brain mets and is otherwise healthy, this is a good time to try ACT, and that she can do Ipi afterwards, but that Ipi would exclude her from ACT.

Thoughts welcome.

Thanks.

Maryv

Hi,

I am new to this forum.  My mum has stage V (lg mass in abdominal cavity, lymph nodes).  IL-2 did not work.  She is exploring trials. Her current oncologist was about to start her on Ipi alone as they don't have any other trials right now that suit her.  We just want to make sure we're not excluding her from any trials by starting it, so this sequencing discussion is of interest.

She has a meeting with Dr. Rosenberg's team to talk about ACT, and has been identified as a candidate for a trial at DFCI with PD-L1 and Ipi.  We heard that while she doesn't have brain mets and is otherwise healthy, this is a good time to try ACT, and that she can do Ipi afterwards, but that Ipi would exclude her from ACT.

Thoughts welcome.

Thanks.

Maryv