Just need some input
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Just need some input

› Forums › General Melanoma Community › Just need some input

  • Post
    • October 30, 2011 at 2:33 am
    deardad
    Participant

    Hi just want ask you all for your opinion.

    Recently my dad saw his neurosurgeon who told him that his latest MRI (after 4 months) was clear (hooray). He also asked if dad was going to have radiation. Apparently the neurosurgeon and the oncologist work independent of each other so he was not aware that my dad was on vemurafenib. When on a trial can you have WBR? Does anyone think it's worth considering? Do we have any evidence that vermurafenib crosses the blood brain barrier?

    Hi just want ask you all for your opinion.

    Recently my dad saw his neurosurgeon who told him that his latest MRI (after 4 months) was clear (hooray). He also asked if dad was going to have radiation. Apparently the neurosurgeon and the oncologist work independent of each other so he was not aware that my dad was on vemurafenib. When on a trial can you have WBR? Does anyone think it's worth considering? Do we have any evidence that vermurafenib crosses the blood brain barrier?

     I know that we are in a good place at the moment and I am so grateful, I just want dad to have access to something more durable while the disease is at bay (so to speak). I don't think you can move onto anything else until the disease progresses.

    Thanks in advance

    Nahmi from Melbourne

Viewing 8 reply threads
  • Replies
      • October 30, 2011 at 10:27 am
      FormerCaregiver
      Participant

      Nahmi, if your dad has a clear brain MRI I can see no need for WBR. Radiation treatment
      can have significant side effects, and it has to be considered in light of any potential
      benefit to the patient.

      I am not certain if vemurafenib (Zelboraf) crosses the blood brain barrier, as it
      appears to act indirectly on brain mets. See:
      http://www.melanoma.org/community/mpip-melanoma-patients-information-page/zelboraf-brain-tumors-anyone#comment-25354

      Take care

      Frank from Australia

      • October 30, 2011 at 10:27 am
      FormerCaregiver
      Participant

      Nahmi, if your dad has a clear brain MRI I can see no need for WBR. Radiation treatment
      can have significant side effects, and it has to be considered in light of any potential
      benefit to the patient.

      I am not certain if vemurafenib (Zelboraf) crosses the blood brain barrier, as it
      appears to act indirectly on brain mets. See:
      http://www.melanoma.org/community/mpip-melanoma-patients-information-page/zelboraf-brain-tumors-anyone#comment-25354

      Take care

      Frank from Australia

      • October 30, 2011 at 10:27 am
      FormerCaregiver
      Participant

      Nahmi, if your dad has a clear brain MRI I can see no need for WBR. Radiation treatment
      can have significant side effects, and it has to be considered in light of any potential
      benefit to the patient.

      I am not certain if vemurafenib (Zelboraf) crosses the blood brain barrier, as it
      appears to act indirectly on brain mets. See:
      http://www.melanoma.org/community/mpip-melanoma-patients-information-page/zelboraf-brain-tumors-anyone#comment-25354

      Take care

      Frank from Australia

      • October 30, 2011 at 1:14 pm
      LynnLuc
      Participant

      He best check with his primary oncologist doing the trial…if you do other things not part of the trial -they will  kick you out of the trial! -Lynn

      • October 30, 2011 at 1:14 pm
      LynnLuc
      Participant

      He best check with his primary oncologist doing the trial…if you do other things not part of the trial -they will  kick you out of the trial! -Lynn

      • October 30, 2011 at 1:14 pm
      LynnLuc
      Participant

      He best check with his primary oncologist doing the trial…if you do other things not part of the trial -they will  kick you out of the trial! -Lynn

      • October 30, 2011 at 6:53 pm
      jmmm
      Participant
      They found a big brain tumor in my husband last week. It’s too big to remove. His dr. Has worked with zalboraf trials for awhile and has seen it work on brain tumors although officially there is no data on it. I know you have to be off of zalboraf for a week before any type of radiation. I’d check with the oncologist to see his opinion.
      L
      • October 30, 2011 at 6:53 pm
      jmmm
      Participant
      They found a big brain tumor in my husband last week. It’s too big to remove. His dr. Has worked with zalboraf trials for awhile and has seen it work on brain tumors although officially there is no data on it. I know you have to be off of zalboraf for a week before any type of radiation. I’d check with the oncologist to see his opinion.
      L
      • October 30, 2011 at 6:53 pm
      jmmm
      Participant
      They found a big brain tumor in my husband last week. It’s too big to remove. His dr. Has worked with zalboraf trials for awhile and has seen it work on brain tumors although officially there is no data on it. I know you have to be off of zalboraf for a week before any type of radiation. I’d check with the oncologist to see his opinion.
      L
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