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Last combo infusion
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Last combo infusion

› Forums › General Melanoma Community › Last combo infusion

  • Post
    • August 6, 2021 at 3:34 pm
    Christinad
    Participant
      Hi All –

      Tomorrow is the last of the combo infusion of ipi/nivo. I’ve had a hard time with side effects which included one hospital admission.  Just wondering if anyone experienced less side effects after going to the single medication cycle 5? I know everyone is different and have a range of different side effects from minimal to a lot. My question is for those of you who had significant side effects cycle 1-4 did you find any relief thereafter?

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    • Replies
        • August 7, 2021 at 11:40 am
        hxcadam
        Participant
          Everyone is different but many patients who go on to do single Opdivo infusions have a much easier time than with the combo.  Ipilimumab is considered the bad boy but sadly a necessary evil.
          • August 7, 2021 at 5:06 pm
          Christinad
          Participant
            Thank you for your response. I’m hoping that’ll be the case for me.
            • August 9, 2021 at 2:30 pm
            JudiAU
            Participant
              I completed four combos with a short break for a one week hospital admission for high fevers. Followed by brain surgery for met removal and brief radiation. Returned for single therapy and finish next month. The single dose is much easier IMHO. I did eventually have some mild diarrhea but it was manageable and eventually went away, not like what some people experience. I was on low steroids for most of the time. Good luck.
              • August 12, 2021 at 6:33 pm
              Christinad
              Participant
                Thank you for your response. I’m truly miserable. Praying this gets easier.
                • August 13, 2021 at 8:07 am
                Beany
                Participant
                  Hello,

                  I only got through three combos before having drug induced liver damage or very high AST and ALT. ALT was 748. I  was in hospital gor two months and steroids for one year.

                  I am on the single dose of opdivo now and have zero side effects.

                  Regards,

                  • August 13, 2021 at 9:59 am
                  Christinad
                  Participant
                    Wow, I’m sorry to hear you had such a hard time with the combo dose. A 2 month hospital had to be awful! You’re a trooper and such a strong person! So glad you’re tolerating the opdivo well with no side effects.
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