Latest results
REGISTER
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

Latest results

› Forums › General Melanoma Community › Latest results

  • Post
    • December 3, 2016 at 4:50 pm
    JoshF
    Participant

    So LDH went up more and now platelets were elevated. I think high end of range is 450,000 and mine was 488,000. I looked on this forum and everything is low platelet counts…anyone know anything about elevated platelet counts?

    Josh

Viewing 14 reply threads
  • Replies
      • December 3, 2016 at 5:25 pm
      Spl25
      Participant

      I can't see how elevated platelets (in and of itself) would be a bad thing.  I've had elevated platelets a couple of times, which my doctor said was insignificant. 

      • December 3, 2016 at 5:25 pm
      Spl25
      Participant

      I can't see how elevated platelets (in and of itself) would be a bad thing.  I've had elevated platelets a couple of times, which my doctor said was insignificant. 

      • December 3, 2016 at 5:25 pm
      Spl25
      Participant

      I can't see how elevated platelets (in and of itself) would be a bad thing.  I've had elevated platelets a couple of times, which my doctor said was insignificant. 

      • December 3, 2016 at 11:16 pm
      jbronicki
      Participant

      Hey Josh,

      I keep coming back to Mat's response that LDH is a marker for inflammation.  I looked up platelets and they are very connected to the Immune Response and the Immune Response is very closely related to the Inflammatory Response.  I'm not sure what this all means (I need to read the literature further) but it could just be your bodies response during treatment.  I'm not sure it's necessarily a bad thing, your body is fighting and any time your body fights there is inflammation, etc.  So this may be a reactive condition rather than indicative of disease, etc. 

      Again, I'm leaning on my biochemistry/immunology days from college and not a doctor, but I'm going to look into this further.  I think Mat was correct that LDH alone, is only indicative of secondary inflammation.

       https://www.hindawi.com/journals/ah/2012/384685/

      http://www.bloodjournal.org/content/123/18/2759?sso-checked=true

      Hope MDA was ok and let us know if you need anything at all!

      Cheers,

      Jackie

       
      • December 3, 2016 at 11:16 pm
      jbronicki
      Participant

      Hey Josh,

      I keep coming back to Mat's response that LDH is a marker for inflammation.  I looked up platelets and they are very connected to the Immune Response and the Immune Response is very closely related to the Inflammatory Response.  I'm not sure what this all means (I need to read the literature further) but it could just be your bodies response during treatment.  I'm not sure it's necessarily a bad thing, your body is fighting and any time your body fights there is inflammation, etc.  So this may be a reactive condition rather than indicative of disease, etc. 

      Again, I'm leaning on my biochemistry/immunology days from college and not a doctor, but I'm going to look into this further.  I think Mat was correct that LDH alone, is only indicative of secondary inflammation.

       https://www.hindawi.com/journals/ah/2012/384685/

      http://www.bloodjournal.org/content/123/18/2759?sso-checked=true

      Hope MDA was ok and let us know if you need anything at all!

      Cheers,

      Jackie

       
        • December 5, 2016 at 2:43 pm
        JoshF
        Participant

        Thank you Jackie for doing some research! You've always been so kind to me. I'm hoping this isn't all that horrible. You just read about how elevated LDH isn't a good indicator. It sticks in my head. 

        Josh

        • December 5, 2016 at 2:43 pm
        JoshF
        Participant

        Thank you Jackie for doing some research! You've always been so kind to me. I'm hoping this isn't all that horrible. You just read about how elevated LDH isn't a good indicator. It sticks in my head. 

        Josh

        • December 5, 2016 at 2:43 pm
        JoshF
        Participant

        Thank you Jackie for doing some research! You've always been so kind to me. I'm hoping this isn't all that horrible. You just read about how elevated LDH isn't a good indicator. It sticks in my head. 

        Josh

      • December 3, 2016 at 11:16 pm
      jbronicki
      Participant

      Hey Josh,

      I keep coming back to Mat's response that LDH is a marker for inflammation.  I looked up platelets and they are very connected to the Immune Response and the Immune Response is very closely related to the Inflammatory Response.  I'm not sure what this all means (I need to read the literature further) but it could just be your bodies response during treatment.  I'm not sure it's necessarily a bad thing, your body is fighting and any time your body fights there is inflammation, etc.  So this may be a reactive condition rather than indicative of disease, etc. 

      Again, I'm leaning on my biochemistry/immunology days from college and not a doctor, but I'm going to look into this further.  I think Mat was correct that LDH alone, is only indicative of secondary inflammation.

       https://www.hindawi.com/journals/ah/2012/384685/

      http://www.bloodjournal.org/content/123/18/2759?sso-checked=true

      Hope MDA was ok and let us know if you need anything at all!

      Cheers,

      Jackie

       
      • December 4, 2016 at 4:06 pm
      Bubbles
      Participant

      Hey Joshie,

      Just like an increased LDH, increased platelet counts can be caused by many things….including trauma, major surgery, inflammation, auto-immune disorders…..and one may also presume….INDUCED immune "disorders"!!!  Keep in mind that tissue necrosis….like dying, dried up, DEAD, melanoma tumors!!!!…can increase LDH!!!  Not trying to be too much of a Polly Anna…but just say'n!!!  Fingers and toes crossed for you!  Love, c

      • December 4, 2016 at 4:06 pm
      Bubbles
      Participant

      Hey Joshie,

      Just like an increased LDH, increased platelet counts can be caused by many things….including trauma, major surgery, inflammation, auto-immune disorders…..and one may also presume….INDUCED immune "disorders"!!!  Keep in mind that tissue necrosis….like dying, dried up, DEAD, melanoma tumors!!!!…can increase LDH!!!  Not trying to be too much of a Polly Anna…but just say'n!!!  Fingers and toes crossed for you!  Love, c

        • December 5, 2016 at 2:45 pm
        JoshF
        Participant

        Thanks Celeste…I always appreciate your optimism and uplifting attitude. I need to kill some of these bastards off for sure!!!

        love,

        Joshie

        • December 5, 2016 at 2:45 pm
        JoshF
        Participant

        Thanks Celeste…I always appreciate your optimism and uplifting attitude. I need to kill some of these bastards off for sure!!!

        love,

        Joshie

        • December 5, 2016 at 2:45 pm
        JoshF
        Participant

        Thanks Celeste…I always appreciate your optimism and uplifting attitude. I need to kill some of these bastards off for sure!!!

        love,

        Joshie

      • December 4, 2016 at 4:06 pm
      Bubbles
      Participant

      Hey Joshie,

      Just like an increased LDH, increased platelet counts can be caused by many things….including trauma, major surgery, inflammation, auto-immune disorders…..and one may also presume….INDUCED immune "disorders"!!!  Keep in mind that tissue necrosis….like dying, dried up, DEAD, melanoma tumors!!!!…can increase LDH!!!  Not trying to be too much of a Polly Anna…but just say'n!!!  Fingers and toes crossed for you!  Love, c

      • December 4, 2016 at 7:14 pm
      jvictoria
      Participant

      Just prior to my second dosage of IPI/Keytruda my LDH ws 565 U/L. I've had a low grade fever for 3 weeks now.

      • December 4, 2016 at 7:14 pm
      jvictoria
      Participant

      Just prior to my second dosage of IPI/Keytruda my LDH ws 565 U/L. I've had a low grade fever for 3 weeks now.

        • December 5, 2016 at 5:42 pm
        Hukill
        Participant

        I had fever for 6 weeks aroung that same time, took motrin until it stopped.

        • December 5, 2016 at 8:15 pm
        jvictoria
        Participant

        Thanks… I hope it stops soon.

        • December 5, 2016 at 8:15 pm
        jvictoria
        Participant

        Thanks… I hope it stops soon.

        • December 5, 2016 at 8:15 pm
        jvictoria
        Participant

        Thanks… I hope it stops soon.

        • December 5, 2016 at 5:42 pm
        Hukill
        Participant

        I had fever for 6 weeks aroung that same time, took motrin until it stopped.

        • December 5, 2016 at 5:42 pm
        Hukill
        Participant

        I had fever for 6 weeks aroung that same time, took motrin until it stopped.

      • December 4, 2016 at 7:14 pm
      jvictoria
      Participant

      Just prior to my second dosage of IPI/Keytruda my LDH ws 565 U/L. I've had a low grade fever for 3 weeks now.

      • December 5, 2016 at 8:04 am
      Kim K
      Participant

      Cancer patients are at greater risks for clots.  Increased platelet counts may put you at higher risk, just be careful.  I had a pulmonary embolus after my VATS with very minimal tumor burden.  You may want to make sure those numbers aren't getting alarming with your doc.  Just throwing that curve for something to chew on.  Would hate to lose this damned fight from a stupid clot.

      I know I was pissed off when I was in the middle of my attack, hell I couldn't breathe.  How dare I not be given the time to fight this bastard of a disease only to be taken out at the knees by a clot.  Ever since then, when I have surgery ex. ACL reconstruction, I get put on blood thinners for a short time after.  I am allergic to aspirin so that is out.

      Keep up the fight, we have your back.

       

      • December 5, 2016 at 8:04 am
      Kim K
      Participant

      Cancer patients are at greater risks for clots.  Increased platelet counts may put you at higher risk, just be careful.  I had a pulmonary embolus after my VATS with very minimal tumor burden.  You may want to make sure those numbers aren't getting alarming with your doc.  Just throwing that curve for something to chew on.  Would hate to lose this damned fight from a stupid clot.

      I know I was pissed off when I was in the middle of my attack, hell I couldn't breathe.  How dare I not be given the time to fight this bastard of a disease only to be taken out at the knees by a clot.  Ever since then, when I have surgery ex. ACL reconstruction, I get put on blood thinners for a short time after.  I am allergic to aspirin so that is out.

      Keep up the fight, we have your back.

       

      • December 5, 2016 at 8:04 am
      Kim K
      Participant

      Cancer patients are at greater risks for clots.  Increased platelet counts may put you at higher risk, just be careful.  I had a pulmonary embolus after my VATS with very minimal tumor burden.  You may want to make sure those numbers aren't getting alarming with your doc.  Just throwing that curve for something to chew on.  Would hate to lose this damned fight from a stupid clot.

      I know I was pissed off when I was in the middle of my attack, hell I couldn't breathe.  How dare I not be given the time to fight this bastard of a disease only to be taken out at the knees by a clot.  Ever since then, when I have surgery ex. ACL reconstruction, I get put on blood thinners for a short time after.  I am allergic to aspirin so that is out.

      Keep up the fight, we have your back.

       

Viewing 14 reply threads
  • You must be logged in to reply to this topic.
About the MRF Patient Forum

The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.