INC B24360
REGISTER
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

INC B24360

› Forums › General Melanoma Community › INC B24360

  • Post
    • September 22, 2016 at 7:30 pm
    snow white
    Participant

    this is the trial that they are talking about for my Dad.  Have you heard of it?

Viewing 5 reply threads
  • Replies
      • September 22, 2016 at 8:31 pm
      debwray
      Participant

      Hi Jennifer,

      Think you are quoting the reference code for epacadostat.

      The clinical trial will have an entry on clinicaltrials.gov  and therefore will begin nct followed by so!me numbers. If your dad is considering a trial he should be offered a written description of the trial protocol do he knows what he will be given etc

      It's all confusing…mk3475 is the same as pembrolizumab is the same as keytruda for example.

      Please shout out when you know a bit more.

      Best wishes 

      Deb

      I

      • September 22, 2016 at 8:31 pm
      debwray
      Participant

      Hi Jennifer,

      Think you are quoting the reference code for epacadostat.

      The clinical trial will have an entry on clinicaltrials.gov  and therefore will begin nct followed by so!me numbers. If your dad is considering a trial he should be offered a written description of the trial protocol do he knows what he will be given etc

      It's all confusing…mk3475 is the same as pembrolizumab is the same as keytruda for example.

      Please shout out when you know a bit more.

      Best wishes 

      Deb

      I

      • September 22, 2016 at 8:31 pm
      debwray
      Participant

      Hi Jennifer,

      Think you are quoting the reference code for epacadostat.

      The clinical trial will have an entry on clinicaltrials.gov  and therefore will begin nct followed by so!me numbers. If your dad is considering a trial he should be offered a written description of the trial protocol do he knows what he will be given etc

      It's all confusing…mk3475 is the same as pembrolizumab is the same as keytruda for example.

      Please shout out when you know a bit more.

      Best wishes 

      Deb

      I

        • September 22, 2016 at 8:38 pm
        snow white
        Participant

        Thank you Deb.  It is so overwhelming and confusing!  I will update when I get more infofrown

         

        • September 22, 2016 at 8:38 pm
        snow white
        Participant

        Thank you Deb.  It is so overwhelming and confusing!  I will update when I get more infofrown

         

        • September 22, 2016 at 8:38 pm
        snow white
        Participant

        Thank you Deb.  It is so overwhelming and confusing!  I will update when I get more infofrown

         

      • September 22, 2016 at 8:55 pm
      Bubbles
      Participant

      Deb is right. Icnb24360 is another name for epacadostat which is and IDO inhibitor.

      Here is a study for melanoma patients in which it is combined with nivolumab (also known as Opdivo) an anti-PD1 product.:  https://clinicaltrials.gov/ct2/show/NCT02327078?term=epacadostat&rank=1

      Here is another in which epacadostat is paired with pembrolizumab (a different but similar anti-PD1 product, also known as Keytruda):  https://clinicaltrials.gov/ct2/show/NCT02752074?term=epacadostat&rank=2

      Hopefully thise links will work and give you and idea how trials work. You have to be careful to understand what they are offering. For example…in one of these…one arm gets placebo. So you have to think about what you (or in this case your dad) is really willing to do.

      If I recall properly, your dad is without prior treatment. Why not the ipi/nivo combo? That treatment is FDA approved and has the best response rates going….no trial needed. Celeste

      • September 22, 2016 at 8:55 pm
      Bubbles
      Participant

      Deb is right. Icnb24360 is another name for epacadostat which is and IDO inhibitor.

      Here is a study for melanoma patients in which it is combined with nivolumab (also known as Opdivo) an anti-PD1 product.:  https://clinicaltrials.gov/ct2/show/NCT02327078?term=epacadostat&rank=1

      Here is another in which epacadostat is paired with pembrolizumab (a different but similar anti-PD1 product, also known as Keytruda):  https://clinicaltrials.gov/ct2/show/NCT02752074?term=epacadostat&rank=2

      Hopefully thise links will work and give you and idea how trials work. You have to be careful to understand what they are offering. For example…in one of these…one arm gets placebo. So you have to think about what you (or in this case your dad) is really willing to do.

      If I recall properly, your dad is without prior treatment. Why not the ipi/nivo combo? That treatment is FDA approved and has the best response rates going….no trial needed. Celeste

      • September 22, 2016 at 8:55 pm
      Bubbles
      Participant

      Deb is right. Icnb24360 is another name for epacadostat which is and IDO inhibitor.

      Here is a study for melanoma patients in which it is combined with nivolumab (also known as Opdivo) an anti-PD1 product.:  https://clinicaltrials.gov/ct2/show/NCT02327078?term=epacadostat&rank=1

      Here is another in which epacadostat is paired with pembrolizumab (a different but similar anti-PD1 product, also known as Keytruda):  https://clinicaltrials.gov/ct2/show/NCT02752074?term=epacadostat&rank=2

      Hopefully thise links will work and give you and idea how trials work. You have to be careful to understand what they are offering. For example…in one of these…one arm gets placebo. So you have to think about what you (or in this case your dad) is really willing to do.

      If I recall properly, your dad is without prior treatment. Why not the ipi/nivo combo? That treatment is FDA approved and has the best response rates going….no trial needed. Celeste

        • September 22, 2016 at 9:04 pm
        Bubbles
        Participant

        Additionally, Brian who responded to your last post is right. Your dad's BRAF status, determined from an examination of his tumor type, is very important. If there is a lot of disease – BRAF inhibitors can decrease the level of tumor burden very rapidly if you are BRAF positive. The downside is that for most, they do not maintain that effect for much longer than 6 months or so. However, they can be very helpful in decreasing tumor burden rapidly and once that is done…switch the patient rapidly to an immunotherapy (ipi/nivo/pembro) which work best in patients with a lower tumor burden.

        It is also essential that your father is being followed by a melanoma specialist….an oncologist very familiar with melanoma and a history of treating many patients with melanoma.

        There are reports, which include data and explanations for most of these things, on my blog. Use the search bubble if you are interested. I wish you and your father well. Celeste

        • September 22, 2016 at 9:04 pm
        Bubbles
        Participant

        Additionally, Brian who responded to your last post is right. Your dad's BRAF status, determined from an examination of his tumor type, is very important. If there is a lot of disease – BRAF inhibitors can decrease the level of tumor burden very rapidly if you are BRAF positive. The downside is that for most, they do not maintain that effect for much longer than 6 months or so. However, they can be very helpful in decreasing tumor burden rapidly and once that is done…switch the patient rapidly to an immunotherapy (ipi/nivo/pembro) which work best in patients with a lower tumor burden.

        It is also essential that your father is being followed by a melanoma specialist….an oncologist very familiar with melanoma and a history of treating many patients with melanoma.

        There are reports, which include data and explanations for most of these things, on my blog. Use the search bubble if you are interested. I wish you and your father well. Celeste

        • September 22, 2016 at 9:04 pm
        Bubbles
        Participant

        Additionally, Brian who responded to your last post is right. Your dad's BRAF status, determined from an examination of his tumor type, is very important. If there is a lot of disease – BRAF inhibitors can decrease the level of tumor burden very rapidly if you are BRAF positive. The downside is that for most, they do not maintain that effect for much longer than 6 months or so. However, they can be very helpful in decreasing tumor burden rapidly and once that is done…switch the patient rapidly to an immunotherapy (ipi/nivo/pembro) which work best in patients with a lower tumor burden.

        It is also essential that your father is being followed by a melanoma specialist….an oncologist very familiar with melanoma and a history of treating many patients with melanoma.

        There are reports, which include data and explanations for most of these things, on my blog. Use the search bubble if you are interested. I wish you and your father well. Celeste

        • September 22, 2016 at 9:22 pm
        snow white
        Participant

        Thank you thank you so much for your reply.  All this information is so much apprecited.  I have referred to your blog, but as this is so new to me, I couldn't make heads or tails of it.  I will follow your links and read it all.  

         

        Again thanks!!!!!!

        • September 22, 2016 at 9:22 pm
        snow white
        Participant

        Thank you thank you so much for your reply.  All this information is so much apprecited.  I have referred to your blog, but as this is so new to me, I couldn't make heads or tails of it.  I will follow your links and read it all.  

         

        Again thanks!!!!!!

        • September 22, 2016 at 9:22 pm
        snow white
        Participant

        Thank you thank you so much for your reply.  All this information is so much apprecited.  I have referred to your blog, but as this is so new to me, I couldn't make heads or tails of it.  I will follow your links and read it all.  

         

        Again thanks!!!!!!

        • September 22, 2016 at 9:46 pm
        BrianP
        Participant

        That was actually Gary (Polymath) who gave the BRAF info but it was pretty good advice so you can give me credit Celeste 🙂

        • September 22, 2016 at 9:46 pm
        BrianP
        Participant

        That was actually Gary (Polymath) who gave the BRAF info but it was pretty good advice so you can give me credit Celeste 🙂

        • September 22, 2016 at 9:46 pm
        BrianP
        Participant

        That was actually Gary (Polymath) who gave the BRAF info but it was pretty good advice so you can give me credit Celeste 🙂

        • September 22, 2016 at 9:54 pm
        Bubbles
        Participant

        Oops! Ought to double check instead of depending on my 'memory'! Sorry, Gary! Still good advice, I think. Hope you're doing okay, Brian! Love, c

        • September 22, 2016 at 9:54 pm
        Bubbles
        Participant

        Oops! Ought to double check instead of depending on my 'memory'! Sorry, Gary! Still good advice, I think. Hope you're doing okay, Brian! Love, c

        • September 22, 2016 at 9:54 pm
        Bubbles
        Participant

        Oops! Ought to double check instead of depending on my 'memory'! Sorry, Gary! Still good advice, I think. Hope you're doing okay, Brian! Love, c

        • September 23, 2016 at 6:08 pm
        Polymath
        Participant

        Hey Celeste & Brian,

        You guys are funny cheeky.  The main thing is this board is such a wealth of information, and the synergy of all of us can help the body and calm the mind.  Thanks to all for the awesome support and information.  FYI, I am kind of stuck in a holding pattern right now.  Nivo appears to be holding things steady for the time being.  Still considering next steps.

        Gary

        • September 23, 2016 at 11:21 pm
        snow white
        Participant

        I am brand new to this board and I can say that it is already bringing me comfort with the knowledge and kindness of its members.  Thanks again for all your helpful info.

        Best to you!

        • September 23, 2016 at 11:21 pm
        snow white
        Participant

        I am brand new to this board and I can say that it is already bringing me comfort with the knowledge and kindness of its members.  Thanks again for all your helpful info.

        Best to you!

        • September 23, 2016 at 11:21 pm
        snow white
        Participant

        I am brand new to this board and I can say that it is already bringing me comfort with the knowledge and kindness of its members.  Thanks again for all your helpful info.

        Best to you!

        • September 23, 2016 at 6:08 pm
        Polymath
        Participant

        Hey Celeste & Brian,

        You guys are funny cheeky.  The main thing is this board is such a wealth of information, and the synergy of all of us can help the body and calm the mind.  Thanks to all for the awesome support and information.  FYI, I am kind of stuck in a holding pattern right now.  Nivo appears to be holding things steady for the time being.  Still considering next steps.

        Gary

        • September 23, 2016 at 6:08 pm
        Polymath
        Participant

        Hey Celeste & Brian,

        You guys are funny cheeky.  The main thing is this board is such a wealth of information, and the synergy of all of us can help the body and calm the mind.  Thanks to all for the awesome support and information.  FYI, I am kind of stuck in a holding pattern right now.  Nivo appears to be holding things steady for the time being.  Still considering next steps.

        Gary

Viewing 5 reply threads
  • You must be logged in to reply to this topic.
About the MRF Patient Forum

The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.

Popular Topics