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Small new Met shows up 10 days post infusion new area
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Small new Met shows up 10 days post infusion new area

› Forums › General Melanoma Community › Small new Met shows up 10 days post infusion new area

  • Post
    • July 21, 2016 at 10:15 pm
    jade1111
    Participant

      Hello! So my mom went to the Drs today.. they decided no infusion based on the rash.. the rash is pretty severe.. they all looked a little shocked.. purple like bumps all over legs and back and some on arms. Also revealing itself was a small purple hard like mass on the arm pimpke sized (her original site is leg). Has anyone heard of these little mets showing up with therapy? They said for now  no biopsy they will just monitor. Was not expecting that part.

      Thanks!!!

    Viewing 11 reply threads
    • Replies
        • July 21, 2016 at 11:33 pm
        Lee Parlier
        Participant

          Are the purple bumps under the skin?

           

          • July 21, 2016 at 11:33 pm
          Lee Parlier
          Participant

            Are the purple bumps under the skin?

             

            • July 21, 2016 at 11:33 pm
            Lee Parlier
            Participant

              Are the purple bumps under the skin?

               

                • July 22, 2016 at 12:33 am
                jade1111
                Participant

                  the rash is purplish/red in color and the pimple/purple like mass is under the skin

                  • July 22, 2016 at 12:33 am
                  jade1111
                  Participant

                    the rash is purplish/red in color and the pimple/purple like mass is under the skin

                    • July 22, 2016 at 12:33 am
                    jade1111
                    Participant

                      the rash is purplish/red in color and the pimple/purple like mass is under the skin

                    • July 22, 2016 at 1:35 pm
                    Patrisa
                    Participant

                      Sounds like pruritus to me…

                        • July 22, 2016 at 3:35 pm
                        jade1111
                        Participant

                          Hmm Dr think the small hard purple lump is a melanoma coming to surface.. the rash is different but happening at same time

                          • July 22, 2016 at 3:35 pm
                          jade1111
                          Participant

                            Hmm Dr think the small hard purple lump is a melanoma coming to surface.. the rash is different but happening at same time

                            • July 22, 2016 at 3:35 pm
                            jade1111
                            Participant

                              Hmm Dr think the small hard purple lump is a melanoma coming to surface.. the rash is different but happening at same time

                            • July 22, 2016 at 1:35 pm
                            Patrisa
                            Participant

                              Sounds like pruritus to me…

                              • July 22, 2016 at 1:35 pm
                              Patrisa
                              Participant

                                Sounds like pruritus to me…

                                • July 22, 2016 at 3:33 pm
                                ed williams
                                Participant

                                  Hi Jade1111, remember that it is early days and not many people have been treated with the combination of Pembro and the Ido inhibitor epacadostat. New side effects can show up that you don't see in just Pembro. I have a link for you to an article from the first phase study. Best Wishes!!!Ed  http://www.cancernetwork.com/smr-2015/epacadostat-pembrolizumab-combo-shows-activity-advanced-melanoma

                                    • July 22, 2016 at 3:36 pm
                                    jade1111
                                    Participant

                                      Thanks Ed!!! I will check it out!

                                      • July 22, 2016 at 3:36 pm
                                      jade1111
                                      Participant

                                        Thanks Ed!!! I will check it out!

                                        • July 22, 2016 at 3:36 pm
                                        jade1111
                                        Participant

                                          Thanks Ed!!! I will check it out!

                                        • July 22, 2016 at 3:33 pm
                                        ed williams
                                        Participant

                                          Hi Jade1111, remember that it is early days and not many people have been treated with the combination of Pembro and the Ido inhibitor epacadostat. New side effects can show up that you don't see in just Pembro. I have a link for you to an article from the first phase study. Best Wishes!!!Ed  http://www.cancernetwork.com/smr-2015/epacadostat-pembrolizumab-combo-shows-activity-advanced-melanoma

                                          • July 22, 2016 at 3:33 pm
                                          ed williams
                                          Participant

                                            Hi Jade1111, remember that it is early days and not many people have been treated with the combination of Pembro and the Ido inhibitor epacadostat. New side effects can show up that you don't see in just Pembro. I have a link for you to an article from the first phase study. Best Wishes!!!Ed  http://www.cancernetwork.com/smr-2015/epacadostat-pembrolizumab-combo-shows-activity-advanced-melanoma

                                            • July 22, 2016 at 3:44 pm
                                            Lee Parlier
                                            Participant

                                              I will tell you my experience but this is strictly mine. I had numerous pencil eraser shaped things coming to the surface as well as what looked like ingrown hairs under the skin. I had numerous biopsies and the ingrown hair like things were melanoma in transit. They were called sattelite tumors. The round things were not melanoma but the bodies reaction to yervoy. They were all purplish. Most of mine have disappeared but not all. Every sattelite tumor is gone (the melanoma in transit) but I still have a few of the pencil eraser shaped nodules.

                                              I want to stress though that this was what I had and what my biopsies showed. 

                                               

                                              "Patients may have a transient worsening of disease, manifested either by progression of known lesions or the appearance of new lesions, before disease stabilizes or tumor regresses. Therefore caution should be taken in abandoning therapy early. In general these delayed responses are not observed in patients with rapidly progressive, symptomatic disease."

                                               

                                              http://www.uptodate.com/contents/immunotherapy-of-advanced-melanoma-with-immune-checkpoint-inhibition

                                              • July 22, 2016 at 3:44 pm
                                              Lee Parlier
                                              Participant

                                                I will tell you my experience but this is strictly mine. I had numerous pencil eraser shaped things coming to the surface as well as what looked like ingrown hairs under the skin. I had numerous biopsies and the ingrown hair like things were melanoma in transit. They were called sattelite tumors. The round things were not melanoma but the bodies reaction to yervoy. They were all purplish. Most of mine have disappeared but not all. Every sattelite tumor is gone (the melanoma in transit) but I still have a few of the pencil eraser shaped nodules.

                                                I want to stress though that this was what I had and what my biopsies showed. 

                                                 

                                                "Patients may have a transient worsening of disease, manifested either by progression of known lesions or the appearance of new lesions, before disease stabilizes or tumor regresses. Therefore caution should be taken in abandoning therapy early. In general these delayed responses are not observed in patients with rapidly progressive, symptomatic disease."

                                                 

                                                http://www.uptodate.com/contents/immunotherapy-of-advanced-melanoma-with-immune-checkpoint-inhibition

                                                  • July 22, 2016 at 4:53 pm
                                                  jade1111
                                                  Participant

                                                    Thanks so much for sharinng your experience Lee as well as the link. It is very much appreciated. We were a little puzzled yesterday when they mentioned melanoma on surface again as we had so much been focusing on the internal.. if that makes sense.

                                                    Best to you! Thanks again!

                                                    • July 22, 2016 at 4:53 pm
                                                    jade1111
                                                    Participant

                                                      Thanks so much for sharinng your experience Lee as well as the link. It is very much appreciated. We were a little puzzled yesterday when they mentioned melanoma on surface again as we had so much been focusing on the internal.. if that makes sense.

                                                      Best to you! Thanks again!

                                                      • July 24, 2016 at 1:35 pm
                                                      Lee Parlier
                                                      Participant

                                                        I was as puzzled as you. I researched a month to figure out what it was. Someone on this site gave me that link. It makes perfect sense. They basically told me the same thing, no biopsy, just watch. I went and got several biopsies anyway. I really thought my regular oncologist should have known what they were. I will now rely on a melanoma Dr. 

                                                         

                                                        "Patients may have a transient worsening of disease, manifested either by progression of known lesions or the appearance of new lesions, before disease stabilizes or tumor regresses. Therefore caution should be taken in abandoning therapy early. In general these delayed responses are not observed in patients with rapidly progressive, symptomatic disease."

                                                         

                                                        The underlined bold sentence caught my eye.

                                                        • July 24, 2016 at 1:35 pm
                                                        Lee Parlier
                                                        Participant

                                                          I was as puzzled as you. I researched a month to figure out what it was. Someone on this site gave me that link. It makes perfect sense. They basically told me the same thing, no biopsy, just watch. I went and got several biopsies anyway. I really thought my regular oncologist should have known what they were. I will now rely on a melanoma Dr. 

                                                           

                                                          "Patients may have a transient worsening of disease, manifested either by progression of known lesions or the appearance of new lesions, before disease stabilizes or tumor regresses. Therefore caution should be taken in abandoning therapy early. In general these delayed responses are not observed in patients with rapidly progressive, symptomatic disease."

                                                           

                                                          The underlined bold sentence caught my eye.

                                                          • July 24, 2016 at 1:35 pm
                                                          Lee Parlier
                                                          Participant

                                                            I was as puzzled as you. I researched a month to figure out what it was. Someone on this site gave me that link. It makes perfect sense. They basically told me the same thing, no biopsy, just watch. I went and got several biopsies anyway. I really thought my regular oncologist should have known what they were. I will now rely on a melanoma Dr. 

                                                             

                                                            "Patients may have a transient worsening of disease, manifested either by progression of known lesions or the appearance of new lesions, before disease stabilizes or tumor regresses. Therefore caution should be taken in abandoning therapy early. In general these delayed responses are not observed in patients with rapidly progressive, symptomatic disease."

                                                             

                                                            The underlined bold sentence caught my eye.

                                                            • July 22, 2016 at 4:53 pm
                                                            jade1111
                                                            Participant

                                                              Thanks so much for sharinng your experience Lee as well as the link. It is very much appreciated. We were a little puzzled yesterday when they mentioned melanoma on surface again as we had so much been focusing on the internal.. if that makes sense.

                                                              Best to you! Thanks again!

                                                            • July 22, 2016 at 3:44 pm
                                                            Lee Parlier
                                                            Participant

                                                              I will tell you my experience but this is strictly mine. I had numerous pencil eraser shaped things coming to the surface as well as what looked like ingrown hairs under the skin. I had numerous biopsies and the ingrown hair like things were melanoma in transit. They were called sattelite tumors. The round things were not melanoma but the bodies reaction to yervoy. They were all purplish. Most of mine have disappeared but not all. Every sattelite tumor is gone (the melanoma in transit) but I still have a few of the pencil eraser shaped nodules.

                                                              I want to stress though that this was what I had and what my biopsies showed. 

                                                               

                                                              "Patients may have a transient worsening of disease, manifested either by progression of known lesions or the appearance of new lesions, before disease stabilizes or tumor regresses. Therefore caution should be taken in abandoning therapy early. In general these delayed responses are not observed in patients with rapidly progressive, symptomatic disease."

                                                               

                                                              http://www.uptodate.com/contents/immunotherapy-of-advanced-melanoma-with-immune-checkpoint-inhibition

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