Triall on patients with melanoma spread to their brain.
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Triall on patients with melanoma spread to their brain.

› Forums › General Melanoma Community › Triall on patients with melanoma spread to their brain.

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      • February 5, 2015 at 11:17 am
      LuckyMan51
      Participant

      Thanks Jerry, Well timed post for me! Just shot my Onc a note asking about a fit for my plan B. Much appreciated.   

      • February 5, 2015 at 11:17 am
      LuckyMan51
      Participant

      Thanks Jerry, Well timed post for me! Just shot my Onc a note asking about a fit for my plan B. Much appreciated.   

      • February 5, 2015 at 11:17 am
      LuckyMan51
      Participant

      Thanks Jerry, Well timed post for me! Just shot my Onc a note asking about a fit for my plan B. Much appreciated.   

        • February 5, 2015 at 12:43 pm
        tschmith
        Participant

        Good to hear from you, Jerry!  Hope all is well.

        Terrie

        • February 5, 2015 at 12:43 pm
        tschmith
        Participant

        Good to hear from you, Jerry!  Hope all is well.

        Terrie

        • February 5, 2015 at 12:43 pm
        tschmith
        Participant

        Good to hear from you, Jerry!  Hope all is well.

        Terrie

        • February 5, 2015 at 1:12 pm
        mary1233
        Participant

        Metastisis to the brain is my biggest fear. Thank you for finding this. Does anyone know if this trial is being duplicated in the US?

        Best wishes to all.

        Mary

        • February 5, 2015 at 1:12 pm
        mary1233
        Participant

        Metastisis to the brain is my biggest fear. Thank you for finding this. Does anyone know if this trial is being duplicated in the US?

        Best wishes to all.

        Mary

        • February 5, 2015 at 1:12 pm
        mary1233
        Participant

        Metastisis to the brain is my biggest fear. Thank you for finding this. Does anyone know if this trial is being duplicated in the US?

        Best wishes to all.

        Mary

      • February 5, 2015 at 1:16 pm
      rick1981
      Participant

      Great news, they used to exclude patients with brain mets from PD1 trials. It seems there are 3 legs: Opdivo/nivolumab, Opdivo/nivolumab + Yervoy/ipilimumab and radiation (not clear if it's with Opdivo).

      My wife's not in a trial but she progressed on the BRAF/MEK combo and developed 12 brain mets, either in the "free fall" period before moving onto PD1 or whilst already on PD1. Anyway, she was allowed to continue and is now having Keytruda/pembrolizumab (4th infusion yesterday), had 5 days of whole brain radiation and today had radiation of her hips (bone mets).

      Will keep everyone posted – even though she's not on a trial,

      Rick 

      • February 5, 2015 at 1:16 pm
      rick1981
      Participant

      Great news, they used to exclude patients with brain mets from PD1 trials. It seems there are 3 legs: Opdivo/nivolumab, Opdivo/nivolumab + Yervoy/ipilimumab and radiation (not clear if it's with Opdivo).

      My wife's not in a trial but she progressed on the BRAF/MEK combo and developed 12 brain mets, either in the "free fall" period before moving onto PD1 or whilst already on PD1. Anyway, she was allowed to continue and is now having Keytruda/pembrolizumab (4th infusion yesterday), had 5 days of whole brain radiation and today had radiation of her hips (bone mets).

      Will keep everyone posted – even though she's not on a trial,

      Rick 

      • February 5, 2015 at 1:16 pm
      rick1981
      Participant

      Great news, they used to exclude patients with brain mets from PD1 trials. It seems there are 3 legs: Opdivo/nivolumab, Opdivo/nivolumab + Yervoy/ipilimumab and radiation (not clear if it's with Opdivo).

      My wife's not in a trial but she progressed on the BRAF/MEK combo and developed 12 brain mets, either in the "free fall" period before moving onto PD1 or whilst already on PD1. Anyway, she was allowed to continue and is now having Keytruda/pembrolizumab (4th infusion yesterday), had 5 days of whole brain radiation and today had radiation of her hips (bone mets).

      Will keep everyone posted – even though she's not on a trial,

      Rick 

        • February 5, 2015 at 3:35 pm
        eturner82
        Participant

        Hi Rick

        Please due keep us posted on your wife, my hubby has bone mets and lung mets and I am very interested in how the PD1 is helping with the bone mets…. my hubby will receive 2nd dose of PD1 tomorrow.

        Thanks

        Emily

        • February 5, 2015 at 3:35 pm
        eturner82
        Participant

        Hi Rick

        Please due keep us posted on your wife, my hubby has bone mets and lung mets and I am very interested in how the PD1 is helping with the bone mets…. my hubby will receive 2nd dose of PD1 tomorrow.

        Thanks

        Emily

        • February 5, 2015 at 3:35 pm
        eturner82
        Participant

        Hi Rick

        Please due keep us posted on your wife, my hubby has bone mets and lung mets and I am very interested in how the PD1 is helping with the bone mets…. my hubby will receive 2nd dose of PD1 tomorrow.

        Thanks

        Emily

        • February 5, 2015 at 4:27 pm
        rick1981
        Participant

        Will do – you can also search posts to see our history. Good luck with the 2nd treatment! Rick

        • February 5, 2015 at 4:27 pm
        rick1981
        Participant

        Will do – you can also search posts to see our history. Good luck with the 2nd treatment! Rick

        • February 5, 2015 at 4:27 pm
        rick1981
        Participant

        Will do – you can also search posts to see our history. Good luck with the 2nd treatment! Rick

      • February 5, 2015 at 1:54 pm
      ed williams
      Participant

      Thanks for the post Jerry!!!! I have been following " Jennifer's Journey " on facebook, she is one of the luck ones to get into the trial in Australia and has just finished her 4th dose of Nivolumab. She is friends with one of the great leaders in Melamona awareness in Australia (Jay Allen). He has been one of the main fighters to get sun tanning beds banned in Australia. I wish every one the best, in their Melanoma journey's. Ed

      • February 5, 2015 at 1:54 pm
      ed williams
      Participant

      Thanks for the post Jerry!!!! I have been following " Jennifer's Journey " on facebook, she is one of the luck ones to get into the trial in Australia and has just finished her 4th dose of Nivolumab. She is friends with one of the great leaders in Melamona awareness in Australia (Jay Allen). He has been one of the main fighters to get sun tanning beds banned in Australia. I wish every one the best, in their Melanoma journey's. Ed

      • February 5, 2015 at 1:54 pm
      ed williams
      Participant

      Thanks for the post Jerry!!!! I have been following " Jennifer's Journey " on facebook, she is one of the luck ones to get into the trial in Australia and has just finished her 4th dose of Nivolumab. She is friends with one of the great leaders in Melamona awareness in Australia (Jay Allen). He has been one of the main fighters to get sun tanning beds banned in Australia. I wish every one the best, in their Melanoma journey's. Ed

      • February 5, 2015 at 8:01 pm
      Bubbles
      Participant

      Yay!  YAY!  YAY!  And a few….It's about time!!!! (s)!!!!  Here's some data I've been YELLING to back up the approach if one is interested!!  Thanks for sharing, Jerry!

      http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/02/ipi-nivo-combo-and-radiation-for.html

      Celeste

      • February 5, 2015 at 8:01 pm
      Bubbles
      Participant

      Yay!  YAY!  YAY!  And a few….It's about time!!!! (s)!!!!  Here's some data I've been YELLING to back up the approach if one is interested!!  Thanks for sharing, Jerry!

      http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/02/ipi-nivo-combo-and-radiation-for.html

      Celeste

      • February 5, 2015 at 8:01 pm
      Bubbles
      Participant

      Yay!  YAY!  YAY!  And a few….It's about time!!!! (s)!!!!  Here's some data I've been YELLING to back up the approach if one is interested!!  Thanks for sharing, Jerry!

      http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/02/ipi-nivo-combo-and-radiation-for.html

      Celeste

        • February 10, 2015 at 7:12 am
        csellers23
        Participant
        Is this keytruda?
        • February 10, 2015 at 7:12 am
        csellers23
        Participant
        Is this keytruda?
        • February 10, 2015 at 7:12 am
        csellers23
        Participant
        Is this keytruda?
        • February 10, 2015 at 6:29 pm
        BrianP
        Participant

        Crystal,

        If I understand your question you are wondering in the first post by Jerry if the drug referred to as nivolumab is Keytruda.  If that's your question the answer is no.

        Kinda confusing but most drugs start out with what I like to call their chemical name and then later they get a commercial name.  There are two big players on the anti-PD1 scene right now.  One is BMS's drug which is nivolumab and is now being marketed as Opdivo.  The second is Merck's pembrolizumab which is now being marketed as Keytruda.  Both drugs are anti-PD1 inhibitors and both drugs have had very similar results on patients with maybe a slight edge to Keytruda but it's probably to early to say for sure.  Hope this answers your question.

        Brian

        • February 10, 2015 at 6:29 pm
        BrianP
        Participant

        Crystal,

        If I understand your question you are wondering in the first post by Jerry if the drug referred to as nivolumab is Keytruda.  If that's your question the answer is no.

        Kinda confusing but most drugs start out with what I like to call their chemical name and then later they get a commercial name.  There are two big players on the anti-PD1 scene right now.  One is BMS's drug which is nivolumab and is now being marketed as Opdivo.  The second is Merck's pembrolizumab which is now being marketed as Keytruda.  Both drugs are anti-PD1 inhibitors and both drugs have had very similar results on patients with maybe a slight edge to Keytruda but it's probably to early to say for sure.  Hope this answers your question.

        Brian

        • February 10, 2015 at 6:29 pm
        BrianP
        Participant

        Crystal,

        If I understand your question you are wondering in the first post by Jerry if the drug referred to as nivolumab is Keytruda.  If that's your question the answer is no.

        Kinda confusing but most drugs start out with what I like to call their chemical name and then later they get a commercial name.  There are two big players on the anti-PD1 scene right now.  One is BMS's drug which is nivolumab and is now being marketed as Opdivo.  The second is Merck's pembrolizumab which is now being marketed as Keytruda.  Both drugs are anti-PD1 inhibitors and both drugs have had very similar results on patients with maybe a slight edge to Keytruda but it's probably to early to say for sure.  Hope this answers your question.

        Brian

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