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POW

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      • July 30, 2014 at 9:17 pm
      POW
      Participant

        I agree, the language in that report is difficult to understand. It might be easier for you to read the original research paper here:

        CTLA4 Blockade Broadens the Peripheral T-Cell Receptor Repertoire (see: http://clincancerres.aacrjournals.org/content/20/9/2424.full )

        The bottom line is that anti-CTL-4 antibodies (ipi; Yervoy) seem to increase the diverstiy of the T-cells in 80% of the patients. This may have a bearing on autoimmune side effects. It does not seem to be related to the effectiveness of the treatment. 

        • July 30, 2014 at 9:17 pm
        POW
        Participant

          I agree, the language in that report is difficult to understand. It might be easier for you to read the original research paper here:

          CTLA4 Blockade Broadens the Peripheral T-Cell Receptor Repertoire (see: http://clincancerres.aacrjournals.org/content/20/9/2424.full )

          The bottom line is that anti-CTL-4 antibodies (ipi; Yervoy) seem to increase the diverstiy of the T-cells in 80% of the patients. This may have a bearing on autoimmune side effects. It does not seem to be related to the effectiveness of the treatment. 

          • July 30, 2014 at 9:17 pm
          POW
          Participant

            I agree, the language in that report is difficult to understand. It might be easier for you to read the original research paper here:

            CTLA4 Blockade Broadens the Peripheral T-Cell Receptor Repertoire (see: http://clincancerres.aacrjournals.org/content/20/9/2424.full )

            The bottom line is that anti-CTL-4 antibodies (ipi; Yervoy) seem to increase the diverstiy of the T-cells in 80% of the patients. This may have a bearing on autoimmune side effects. It does not seem to be related to the effectiveness of the treatment. 

            • June 11, 2014 at 1:29 pm
            POW
            Participant

              Thank you for taking the time to post an update. I'm thrilled that your mother is responding so well to the ipi and SRS.  I hope she continues to feel good and can get back to driving soon. You've been an outstanding health advocate for her!

              • June 11, 2014 at 1:29 pm
              POW
              Participant

                Thank you for taking the time to post an update. I'm thrilled that your mother is responding so well to the ipi and SRS.  I hope she continues to feel good and can get back to driving soon. You've been an outstanding health advocate for her!

                • June 11, 2014 at 1:29 pm
                POW
                Participant

                  Thank you for taking the time to post an update. I'm thrilled that your mother is responding so well to the ipi and SRS.  I hope she continues to feel good and can get back to driving soon. You've been an outstanding health advocate for her!

                  • October 20, 2016 at 2:03 am
                  POW
                  Participant

                    LOL! You folks made MY day! So happy to see you here!

                    • October 20, 2016 at 2:03 am
                    POW
                    Participant

                      LOL! You folks made MY day! So happy to see you here!

                      • October 20, 2016 at 2:03 am
                      POW
                      Participant

                        LOL! You folks made MY day! So happy to see you here!

                        • October 19, 2016 at 12:52 pm
                        POW
                        Participant

                          In situ has a mitosis of 0? I didn't know that. Thank you!

                          • October 19, 2016 at 12:52 pm
                          POW
                          Participant

                            In situ has a mitosis of 0? I didn't know that. Thank you!

                            • October 19, 2016 at 12:52 pm
                            POW
                            Participant

                              In situ has a mitosis of 0? I didn't know that. Thank you!

                              • October 18, 2016 at 7:38 pm
                              POW
                              Participant

                                Thank you both for your replies. That helps a lot. One other question… is the "mitotic index" considered when determining whether or not to do an WLE?

                                Thanks again for your help and advice!

                                • October 18, 2016 at 7:38 pm
                                POW
                                Participant

                                  Thank you both for your replies. That helps a lot. One other question… is the "mitotic index" considered when determining whether or not to do an WLE?

                                  Thanks again for your help and advice!

                                  • October 18, 2016 at 7:38 pm
                                  POW
                                  Participant

                                    Thank you both for your replies. That helps a lot. One other question… is the "mitotic index" considered when determining whether or not to do an WLE?

                                    Thanks again for your help and advice!

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