laurielala

My husband is  Stage IV with mets in his spleen, vertabrae and after Yervoy a couple of spots on his liver.  The Yervoy did not do anything to stop the progression of the disease. I was told the spots on his liver may or may not really be there as Yervoy may have found "activity" and therefore something showed on the PET he had after treatment. He is now in the Merk trial for PD-1. His first infusion was a week ago Thursday.  He has  been experiencing fevers and night sweats.  I called the doctor on call the other night and he suggested a trip to the local ER as we are 90 miles away from the center where he is receiving the drug.  Nothing remarkable came out of the work up at the ER and the on call doctor suggested it was a reaction to the drug and sent him home.  I called the cancer center the next morning to follow up and spoke to the clinical nurse who asked me how he was doing.  At that time he was fever free.  Again last night he had a fever along with night sweats and I gave him a fever reducer and checked him at intervals to make sure the temp didn't go higher.  Fever is one of the side effects of the drug and I didn't get too much information from the nurse as she wasn't the "regular" clinical nurse for that particular trial.   My question is whether the fever is his immune system actually "fired up", so to speak, or is this a reaction that is potentially a problem.  I did not get the impression from the nurse that they were too concerned. It is so difficult to be far enough away from the centers urgent care facility that it is virtually impossible to do anything but use the local ER with doctors who are not at all familiar with the mechanism of these particular drugs.  Has anyone experienced the fevers and night sweats while on the drug?  Just feel like there are too many unknowns!!

Thanks

My husband is  Stage IV with mets in his spleen, vertabrae and after Yervoy a couple of spots on his liver.  The Yervoy did not do anything to stop the progression of the disease. I was told the spots on his liver may or may not really be there as Yervoy may have found "activity" and therefore something showed on the PET he had after treatment. He is now in the Merk trial for PD-1. His first infusion was a week ago Thursday.  He has  been experiencing fevers and night sweats.  I called the doctor on call the other night and he suggested a trip to the local ER as we are 90 miles away from the center where he is receiving the drug.  Nothing remarkable came out of the work up at the ER and the on call doctor suggested it was a reaction to the drug and sent him home.  I called the cancer center the next morning to follow up and spoke to the clinical nurse who asked me how he was doing.  At that time he was fever free.  Again last night he had a fever along with night sweats and I gave him a fever reducer and checked him at intervals to make sure the temp didn't go higher.  Fever is one of the side effects of the drug and I didn't get too much information from the nurse as she wasn't the "regular" clinical nurse for that particular trial.   My question is whether the fever is his immune system actually "fired up", so to speak, or is this a reaction that is potentially a problem.  I did not get the impression from the nurse that they were too concerned. It is so difficult to be far enough away from the centers urgent care facility that it is virtually impossible to do anything but use the local ER with doctors who are not at all familiar with the mechanism of these particular drugs.  Has anyone experienced the fevers and night sweats while on the drug?  Just feel like there are too many unknowns!!

Thanks

My husband is  Stage IV with mets in his spleen, vertabrae and after Yervoy a couple of spots on his liver.  The Yervoy did not do anything to stop the progression of the disease. I was told the spots on his liver may or may not really be there as Yervoy may have found "activity" and therefore something showed on the PET he had after treatment. He is now in the Merk trial for PD-1. His first infusion was a week ago Thursday.  He has  been experiencing fevers and night sweats.  I called the doctor on call the other night and he suggested a trip to the local ER as we are 90 miles away from the center where he is receiving the drug.  Nothing remarkable came out of the work up at the ER and the on call doctor suggested it was a reaction to the drug and sent him home.  I called the cancer center the next morning to follow up and spoke to the clinical nurse who asked me how he was doing.  At that time he was fever free.  Again last night he had a fever along with night sweats and I gave him a fever reducer and checked him at intervals to make sure the temp didn't go higher.  Fever is one of the side effects of the drug and I didn't get too much information from the nurse as she wasn't the "regular" clinical nurse for that particular trial.   My question is whether the fever is his immune system actually "fired up", so to speak, or is this a reaction that is potentially a problem.  I did not get the impression from the nurse that they were too concerned. It is so difficult to be far enough away from the centers urgent care facility that it is virtually impossible to do anything but use the local ER with doctors who are not at all familiar with the mechanism of these particular drugs.  Has anyone experienced the fevers and night sweats while on the drug?  Just feel like there are too many unknowns!!

Thanks