Another cream that works about 6 hours is called Triamcinolone. It's inexpensive and if you apply directly on the itch area (which with me is nearly 70% of the body) then you get excellent relief for about 4 hours, after which the itching returns lightly. I use it twice a day. Morning and evening. This itching could last a year after treatments and it has proved difficult to get the oncologist and others in the med field to understand just how intensive it is. I recommended to our oncologist that he take a few infusions. That way maybe someone in the industry will be motivated to design a no-itch Keytruda. P.S. Don't believe all the hype Keytruda advertises. Most of it is B.S.