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Yervoy / IPI Restart after side effects
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Yervoy / IPI Restart after side effects

› Forums › General Melanoma Community › Yervoy / IPI Restart after side effects

  • Post
    • March 15, 2013 at 2:14 am
    ncdaniel
    Participant

      My wife had her first Dose of Yervoy on 2/6/13 now has had major problems colitis  now on 80mg Prednisone reducing to 60 for 3 weeks then further reduction. Has anyone had bad first/second dose reaction and then able to continue with Yervoy? What happened on restart any better? Hoping to continue but wondering what  others experience was.

      Daniel

      My wife had her first Dose of Yervoy on 2/6/13 now has had major problems colitis  now on 80mg Prednisone reducing to 60 for 3 weeks then further reduction. Has anyone had bad first/second dose reaction and then able to continue with Yervoy? What happened on restart any better? Hoping to continue but wondering what  others experience was.

      Daniel

    Viewing 2 reply threads
    • Replies
        • March 15, 2013 at 1:47 pm
        d1i2x3i4e5
        Participant

          I had the Yervoy treatment right after it was approved March 2011.   I had three treatments between May 2011 and July 2011.  After the third treatment I too developed severe colitis and had to be hospitalized for eight days.  Since that time I have not been able to take the Yervoy treatments.  I asked the doctor when I was in the hospital if I could still take the last treatment even though I had developed colitis.  Her response was that they couldn't kill me to cure me. 

          Since that time my regular oncologist told me I am ineligible to have further Yervoy treatments since I had such a bad side effect of colitis and since I was on steroids for over four months to get the colitis under control I am not eligible to take the PD1 treatments because PD1 has a lot of the same make up as the Yervoy treatment and colitis is one of the big side effects for PD1. 

          I haven't treated since July 2011 other than radiation to my head.  I am currently under the wait and see program which is very nerve racking.  I feel the Yervoy did do some good and wish I could have finished the treatments.  Some of my tumors have resolved and some have disappeared from the Yervoy treatment.  However, I still do have other areas that have been increasing in size.

          I hope this answer is in line with what your doctor will tell you also.  There is also a lot of treatments available if your wife has the BRAF mutation which I do not have.

          Good luck in your journey. 

          Karen in Florida

           

          • March 15, 2013 at 1:47 pm
          d1i2x3i4e5
          Participant

            I had the Yervoy treatment right after it was approved March 2011.   I had three treatments between May 2011 and July 2011.  After the third treatment I too developed severe colitis and had to be hospitalized for eight days.  Since that time I have not been able to take the Yervoy treatments.  I asked the doctor when I was in the hospital if I could still take the last treatment even though I had developed colitis.  Her response was that they couldn't kill me to cure me. 

            Since that time my regular oncologist told me I am ineligible to have further Yervoy treatments since I had such a bad side effect of colitis and since I was on steroids for over four months to get the colitis under control I am not eligible to take the PD1 treatments because PD1 has a lot of the same make up as the Yervoy treatment and colitis is one of the big side effects for PD1. 

            I haven't treated since July 2011 other than radiation to my head.  I am currently under the wait and see program which is very nerve racking.  I feel the Yervoy did do some good and wish I could have finished the treatments.  Some of my tumors have resolved and some have disappeared from the Yervoy treatment.  However, I still do have other areas that have been increasing in size.

            I hope this answer is in line with what your doctor will tell you also.  There is also a lot of treatments available if your wife has the BRAF mutation which I do not have.

            Good luck in your journey. 

            Karen in Florida

             

            • March 15, 2013 at 1:47 pm
            d1i2x3i4e5
            Participant

              I had the Yervoy treatment right after it was approved March 2011.   I had three treatments between May 2011 and July 2011.  After the third treatment I too developed severe colitis and had to be hospitalized for eight days.  Since that time I have not been able to take the Yervoy treatments.  I asked the doctor when I was in the hospital if I could still take the last treatment even though I had developed colitis.  Her response was that they couldn't kill me to cure me. 

              Since that time my regular oncologist told me I am ineligible to have further Yervoy treatments since I had such a bad side effect of colitis and since I was on steroids for over four months to get the colitis under control I am not eligible to take the PD1 treatments because PD1 has a lot of the same make up as the Yervoy treatment and colitis is one of the big side effects for PD1. 

              I haven't treated since July 2011 other than radiation to my head.  I am currently under the wait and see program which is very nerve racking.  I feel the Yervoy did do some good and wish I could have finished the treatments.  Some of my tumors have resolved and some have disappeared from the Yervoy treatment.  However, I still do have other areas that have been increasing in size.

              I hope this answer is in line with what your doctor will tell you also.  There is also a lot of treatments available if your wife has the BRAF mutation which I do not have.

              Good luck in your journey. 

              Karen in Florida

               

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