› Forums › General Melanoma Community › Yervoy induction infusions completed but side effects have stopped any maintenance doses
- This topic has 12 replies, 4 voices, and was last updated 12 years, 2 months ago by
jogo.
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- March 8, 2012 at 12:57 pm
My husband was in the clincial trial interferon vs. ipi. He was able to get all four induction infusions. About 10 days after his fourth infusion, he developed colitis from the ipi. That landed him in the hospital for five days. Last Friday, 25 days post ipi, he was hospitalized again for hepatoxicity. His liver numbers are still up. So far, this hospital stay is day seven and he is still inpatient.
My husband was in the clincial trial interferon vs. ipi. He was able to get all four induction infusions. About 10 days after his fourth infusion, he developed colitis from the ipi. That landed him in the hospital for five days. Last Friday, 25 days post ipi, he was hospitalized again for hepatoxicity. His liver numbers are still up. So far, this hospital stay is day seven and he is still inpatient.
He had CT scans on 2/24/12. Those results have come back. He now has spots on his spine and right pelvis. They did a bone biopsy Tuesday on the right pelvis. We are still awaiting those results.
His oncologist is not recommending any further immunotherapy due to the reaction he has encountered with the ipi. If the biopsy shows melanoma, (which I will be shocked if its not) she is saying chemotherapy.
In your experience, what drugs are we likely to see chemotherapy wise?
If it is melanoma again, that will move him to Stage 4 from Stage 3b.
I need your help to know what our next step is or should be.
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- March 8, 2012 at 2:49 pm
Hello! I wanted to post because this sounds so close to my husbands situation. He is a stage 3b and was started on a clinical trial ipi vs. inerferon. He has only taken 2 infusions and was put in the hospital for 6 days due to colitis. He is supposed to go to Dr next week to decide if he will continue treatments after being so sick. He is also due for scans this months. He was first diagnosed in October 2011. This decisions are some of the hardest that you will ever have to make. Not easy at all. Hope all goes well with your husband. You are the only person i have seen post on here that is apart of the ipi vs. interferon trial.
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- March 8, 2012 at 2:49 pm
Hello! I wanted to post because this sounds so close to my husbands situation. He is a stage 3b and was started on a clinical trial ipi vs. inerferon. He has only taken 2 infusions and was put in the hospital for 6 days due to colitis. He is supposed to go to Dr next week to decide if he will continue treatments after being so sick. He is also due for scans this months. He was first diagnosed in October 2011. This decisions are some of the hardest that you will ever have to make. Not easy at all. Hope all goes well with your husband. You are the only person i have seen post on here that is apart of the ipi vs. interferon trial.
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- March 8, 2012 at 2:49 pm
Hello! I wanted to post because this sounds so close to my husbands situation. He is a stage 3b and was started on a clinical trial ipi vs. inerferon. He has only taken 2 infusions and was put in the hospital for 6 days due to colitis. He is supposed to go to Dr next week to decide if he will continue treatments after being so sick. He is also due for scans this months. He was first diagnosed in October 2011. This decisions are some of the hardest that you will ever have to make. Not easy at all. Hope all goes well with your husband. You are the only person i have seen post on here that is apart of the ipi vs. interferon trial.
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- March 10, 2012 at 11:54 am
BRAF wild type -
- March 10, 2012 at 11:54 am
BRAF wild type -
- March 10, 2012 at 11:54 am
BRAF wild type -
- September 22, 2013 at 2:32 am
This is all happening very quickly for me. I felt a lump on the left side of my face May 6th. June 6th, I had a total left parotidectomy and radical disection of the the lymph nodes/glands of the left side of my neck. The primary melanoma was never located nor identified. After testing and randomization, my first infusion was July 30th. I had 2 infusions of ipilimumab and had diarreah for a few days before I was to have my 3rd infusion. It [diarreah] stopped after 2 days of Budesonide and Imodium. It [diarreah] resumed three days later, the weekend before my rescheduled [3rd] infusion. I also had a temperarure of 101.7 F. I was hospitalized. A colonoscopy confirmed ipilimummab induced colotis. I'm on a steroid regemin [Prednisone starting 120 mg and tapering]. The oncology team told me I will remain in the clinical trial but will not be resuming the infusions. I had just 2 infusions of 3 mg/ Kg body weight. I am now dealing with colotis. It's been a five month roller coater ride. The half full glass theory is that my immune system has been activated. Now it needs direction.
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- September 22, 2013 at 2:32 am
This is all happening very quickly for me. I felt a lump on the left side of my face May 6th. June 6th, I had a total left parotidectomy and radical disection of the the lymph nodes/glands of the left side of my neck. The primary melanoma was never located nor identified. After testing and randomization, my first infusion was July 30th. I had 2 infusions of ipilimumab and had diarreah for a few days before I was to have my 3rd infusion. It [diarreah] stopped after 2 days of Budesonide and Imodium. It [diarreah] resumed three days later, the weekend before my rescheduled [3rd] infusion. I also had a temperarure of 101.7 F. I was hospitalized. A colonoscopy confirmed ipilimummab induced colotis. I'm on a steroid regemin [Prednisone starting 120 mg and tapering]. The oncology team told me I will remain in the clinical trial but will not be resuming the infusions. I had just 2 infusions of 3 mg/ Kg body weight. I am now dealing with colotis. It's been a five month roller coater ride. The half full glass theory is that my immune system has been activated. Now it needs direction.
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- September 22, 2013 at 2:32 am
This is all happening very quickly for me. I felt a lump on the left side of my face May 6th. June 6th, I had a total left parotidectomy and radical disection of the the lymph nodes/glands of the left side of my neck. The primary melanoma was never located nor identified. After testing and randomization, my first infusion was July 30th. I had 2 infusions of ipilimumab and had diarreah for a few days before I was to have my 3rd infusion. It [diarreah] stopped after 2 days of Budesonide and Imodium. It [diarreah] resumed three days later, the weekend before my rescheduled [3rd] infusion. I also had a temperarure of 101.7 F. I was hospitalized. A colonoscopy confirmed ipilimummab induced colotis. I'm on a steroid regemin [Prednisone starting 120 mg and tapering]. The oncology team told me I will remain in the clinical trial but will not be resuming the infusions. I had just 2 infusions of 3 mg/ Kg body weight. I am now dealing with colotis. It's been a five month roller coater ride. The half full glass theory is that my immune system has been activated. Now it needs direction.
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