You'd think I'd be old hat at this, BUT……..I just started my 3rd course of Yervoy. The first was in clinical trial, and the last after FDA approval. My second course I developed pretty severe diarrhea after my 3rd infusion and was put on high dose steriods and was able to finish the 4th dose. Given that I had 33 months of stability on Yervoy, and I have metastatic ocular melanoma, which does not usually respond as well as cutaneous does to certain drugs, it was recommended to do the 3rd course of Yervoy. It seems to me that I remember someone saying something about Entocort for diarrhea and that it stopped it quickly. Please let me know what has worked for you.