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Will Start Taf/Mek combo today hopefully, thoughts?
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Will Start Taf/Mek combo today hopefully, thoughts?

› Forums › General Melanoma Community › Will Start Taf/Mek combo today hopefully, thoughts?

  • Post
    • November 6, 2015 at 9:42 am
    davekarrie
    Participant

      Hello all,

      I was on a clinical trial with Keytruda and IDO inhibitor, but my lung mets are growing close to my heart and other lymph node masses bigger in chest, in addition to one on left adrenal gland and kidney giving me pain at times. Was rushed to ER on Sunday with so much pain. Anyway, I know the Taf/Mek combo usually works for BRAF but is limited to around 9 months or so. I am wondering for those that have done Taf/Mek how you are doing, are you NED, course of treatment etc.?  I just want to get ducks in a row if this fails and we have to shift gears again.  My oncologist said once tumors shrink with combo we weill come back in with another PD1 before the combo stops working.  Much love to you all and thanks for any help! Dave

    Viewing 2 reply threads
    • Replies
        • November 6, 2015 at 1:39 pm
        Bubbles
        Participant

          Hey Dave, 

          I have not taken BRAF/MEK inhibitors….but thought some of these articles might be heartening!

          http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/04/brafi-better-when-combined-with-or.html

          Here's another post with several articles that deal with resistance and remission:

          http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/07/brafi-what-predicts-resistance.html

          Not sure how much any of that helps…but I wish you my best. Celeste

            • November 7, 2015 at 7:07 am
            davekarrie
            Participant

              Thanks Celeste, I will check them out!

              • November 11, 2015 at 4:17 am
              paul
              Participant

                Hi Dave,

                I have been on MEK combo for more than a year and a half now, and seem to be doing well on it. I work full time. From what I've read, including personal accounts on this site, responses differ greatly; for some, it seems to work for several years. Wishing you a good result with it–

                Paul

                • November 12, 2015 at 12:34 pm
                davekarrie
                Participant

                  Paul,

                   

                  That is great, are you NED now?  I have been feeling much better since starting the combo last Friday, so I'm hoping its working already!  My big question is when/if to switch from combo since it usually finds a way around melanoma, but some stay NED on it also?

                  • November 12, 2015 at 12:34 pm
                  davekarrie
                  Participant

                    Paul,

                     

                    That is great, are you NED now?  I have been feeling much better since starting the combo last Friday, so I'm hoping its working already!  My big question is when/if to switch from combo since it usually finds a way around melanoma, but some stay NED on it also?

                    • November 12, 2015 at 12:34 pm
                    davekarrie
                    Participant

                      Paul,

                       

                      That is great, are you NED now?  I have been feeling much better since starting the combo last Friday, so I'm hoping its working already!  My big question is when/if to switch from combo since it usually finds a way around melanoma, but some stay NED on it also?

                      • November 11, 2015 at 4:17 am
                      paul
                      Participant

                        Hi Dave,

                        I have been on MEK combo for more than a year and a half now, and seem to be doing well on it. I work full time. From what I've read, including personal accounts on this site, responses differ greatly; for some, it seems to work for several years. Wishing you a good result with it–

                        Paul

                        • November 11, 2015 at 4:17 am
                        paul
                        Participant

                          Hi Dave,

                          I have been on MEK combo for more than a year and a half now, and seem to be doing well on it. I work full time. From what I've read, including personal accounts on this site, responses differ greatly; for some, it seems to work for several years. Wishing you a good result with it–

                          Paul

                          • November 7, 2015 at 7:07 am
                          davekarrie
                          Participant

                            Thanks Celeste, I will check them out!

                            • November 7, 2015 at 7:07 am
                            davekarrie
                            Participant

                              Thanks Celeste, I will check them out!

                            • November 6, 2015 at 1:39 pm
                            Bubbles
                            Participant

                              Hey Dave, 

                              I have not taken BRAF/MEK inhibitors….but thought some of these articles might be heartening!

                              http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/04/brafi-better-when-combined-with-or.html

                              Here's another post with several articles that deal with resistance and remission:

                              http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/07/brafi-what-predicts-resistance.html

                              Not sure how much any of that helps…but I wish you my best. Celeste

                              • November 6, 2015 at 1:39 pm
                              Bubbles
                              Participant

                                Hey Dave, 

                                I have not taken BRAF/MEK inhibitors….but thought some of these articles might be heartening!

                                http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/04/brafi-better-when-combined-with-or.html

                                Here's another post with several articles that deal with resistance and remission:

                                http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/07/brafi-what-predicts-resistance.html

                                Not sure how much any of that helps…but I wish you my best. Celeste

                            Viewing 2 reply threads
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