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Why do liver enzymes fall after 2nd nivo/ipi infusion?
I have seen no data to support the assumption that liver enzymes decrease after patients attain their second infusion of ipi/nivo. As a matter of fact, elevated liver enzymes can be an unwanted side effect of immunotherapy and all immunotherapy side effects tend to increase over time/exposure to therapy and occasionally rear their ugly heads in a rather random fashion. In your case, however, it would seem to me that your the initial elevations in your liver function values may have been related to the mets you had in your liver and hopefully, due to the combo, they are now shrinking, thus leading to your decreased lab values. Alternatively, perhaps these values have decreased due to the steroids that I seem to recall your doc was giving you simultaneously with your infusions.
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