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Update- Study drugs

Forums General Melanoma Community Update- Study drugs

  • Post
    emilypen
    Participant

      Hi All,

      Just wanted to give you an update. My husband is participating in a combo drug study :http://clinicaltrials.gov/ct2/show/NCT01155453

      Which is a combo study of 2 drugs, one that works on the P13K pathway and one on the MEK pathway ( which is in the same pathway as BRAF).

      Hi All,

      Just wanted to give you an update. My husband is participating in a combo drug study :http://clinicaltrials.gov/ct2/show/NCT01155453

      Which is a combo study of 2 drugs, one that works on the P13K pathway and one on the MEK pathway ( which is in the same pathway as BRAF).

      It's been 2 weeks and the change in him is astounding, to me at least, the docs are of course more circumspect, but my hubby can tell the pain is getting less every day, he actually forgot to take his morphine for 2 hours the other night… which is amazing as he is on 60mg slow release twice a day and before the drug was taking breakthrough pain meds at least once a day.

      His energy is up, he's sleeping better, apetite is good and for the first time in a long time he's really eager to get back to work!… :-) so my fingers and toes remained crossed… the next scan is on Oct 12th.

      I'll keep you posted.

       

      Emily

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    • Replies
        Rebecca and Bob
        Participant

          Emily,

           

          That's great to hear. Your husband knows his own body better than anyone. I hope these doctors finally figure out the right combo with these treatments. Thanks for sharing your information about the trial.

           

          Hope to hear good news for you in Oct.

          Rebecca

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          Rebecca and Bob
          Participant

            Emily,

             

            That's great to hear. Your husband knows his own body better than anyone. I hope these doctors finally figure out the right combo with these treatments. Thanks for sharing your information about the trial.

             

            Hope to hear good news for you in Oct.

            Rebecca

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            Sherron
            Participant

              Sounds like really good news for your husband.  So glad his pain level is down.

              Take Care,

              Sherron, wife to Jim

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              Sherron
              Participant

                Sounds like really good news for your husband.  So glad his pain level is down.

                Take Care,

                Sherron, wife to Jim

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                lhaley
                Participant

                  Great that your husband is feeling better!  Please keep us posted.

                  Linda

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                  lhaley
                  Participant

                    Great that your husband is feeling better!  Please keep us posted.

                    Linda

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                    ValinMtl
                    Participant

                      Thanks for this information Emily.  My prayers are with you for the 12th.  It's so nice to hear that his pain level is getting LESS!!!  I'm keeping this trial on my potential plan B. Val

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                      ValinMtl
                      Participant

                        Thanks for this information Emily.  My prayers are with you for the 12th.  It's so nice to hear that his pain level is getting LESS!!!  I'm keeping this trial on my potential plan B. Val

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                        Terra
                        Participant

                          Emily, glad to hear he is feeling better, I hope it continues.  Unfortunately, Derek was randomized into the DTIC arm in his trial instead of the experimental drug, IL-21, but we'll hope for the best.  Worse case it won't work and he can try ipi.  Although we are still waiting for the NRAS testing to be complete at PMH so we con consider this same trial you guys are doing. 

                          Also, we will be in Toronto for the first trt of DTIC and if Derek tolerates it well, maybe we could get together the next we are in TO for his next injection.  

                          Will touch base with you, but happy to hear your good news.

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                          Terra
                          Participant

                            Emily, glad to hear he is feeling better, I hope it continues.  Unfortunately, Derek was randomized into the DTIC arm in his trial instead of the experimental drug, IL-21, but we'll hope for the best.  Worse case it won't work and he can try ipi.  Although we are still waiting for the NRAS testing to be complete at PMH so we con consider this same trial you guys are doing. 

                            Also, we will be in Toronto for the first trt of DTIC and if Derek tolerates it well, maybe we could get together the next we are in TO for his next injection.  

                            Will touch base with you, but happy to hear your good news.

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                            jag
                            Participant

                              very happy to hear this news.  I hope he continues to do better.

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                              jag
                              Participant

                                very happy to hear this news.  I hope he continues to do better.

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                                MaryD
                                Participant

                                  Very encouraging news!   So glad your husband is feeling better each and wishing him continued improvement with this combo.

                                  Best regards,

                                   

                                  Mary

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                                  MaryD
                                  Participant

                                    Very encouraging news!   So glad your husband is feeling better each and wishing him continued improvement with this combo.

                                    Best regards,

                                     

                                    Mary

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                                    sharmon
                                    Participant

                                      Great News,

                                      My husband has been on Mek alone since February and his scans are on the 11th of Oct.  The combo trials are suppose to awesome.  Sounds like it is working and my husband was off all pain meds within and month when he started.  Keep us posted on his progress and praying for a great scan.

                                      Sharon and Brent

                                       

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                                      sharmon
                                      Participant

                                        Great News,

                                        My husband has been on Mek alone since February and his scans are on the 11th of Oct.  The combo trials are suppose to awesome.  Sounds like it is working and my husband was off all pain meds within and month when he started.  Keep us posted on his progress and praying for a great scan.

                                        Sharon and Brent

                                         

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