› Forums › Cutaneous Melanoma Community › Unusual case of stage 4 melanoma-cryotherapy next step?
- This topic has 9 replies, 4 voices, and was last updated 6 years, 1 month ago by BrianP.
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- September 16, 2018 at 12:38 pm
To all warriors,
My husband Bill has had stage 4 acral lentiginous melanoma for over 5 years. His treatments have been vats surgery, TIL at NIH, ipi/ nivo trial, vats surgery, nivo alone, vats surgery and for the last almost three years a her-2 drug after Sloan Kettering discovered he had a high expression of the mutation. He just had scans last Monday and after being stable since the start of the drug he has two new lung nodules in the right lung that has had 3 vats surgeries!!! It’s so damn frustrating!!! They will do a biopsy this week so Sloan Kettering can do an analysis again. Because his platelets are around 85 for the last three months and his liver numbers are very high, we are extremely concerned about doing another her-2 drug combination that includes chemo. SOLE suggested cryotherapy and we’re seriously considering it. We live in the Washington DC area, but are very willing to travel if necessary. My husband feels great and in fact is playing 18 holes of golf today. Any advice is very welcome!! Thanks so much!!
Maureen
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- September 16, 2018 at 1:55 pm
Hi Maureen, what research have you found on cryotherapy?
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- September 16, 2018 at 6:16 pm
Kim et al. Journal for ImmunoTherapy of Cancer 2015, 3(Suppl 2):P137 http://www.immunotherapyofcancer.org/content/3/S2/P137
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- September 16, 2018 at 2:57 pm
Hi Maureen, i dont have any advice for your hubby but i do have support! Jeewhiz! I looked up Cryotherapy & also “CryoSurgery” wow! sounds good? I know my UFC fighters (Ultimate Fighting) they use cryo to heal their muscles/bones but wow! To realy get in there and kill tumor activity is amazing! Id be to cold!! Lol..whatever you both choose were behind you guys…Mike-
- September 16, 2018 at 6:18 pm
Thanks Mike! Wishing you the best!
Maureen
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- September 16, 2018 at 10:34 pm
Hi Maureen, interesting stuff cryoablation at MD Anderson. It seems that they are moving since that trial in 2015 more towards other injectables like TLR9 anonist (IMO-2125) and CD40 agonist ApX005m (Apexigen INc). Here is a recent article about MD Anderson work and one of the trials that they are running at present.http://www.clinicsinoncology.com/pdfs_folder/cio-v2-id1272.pdf https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2016-00675&r=1
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- September 16, 2018 at 10:35 pm
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- September 16, 2018 at 10:36 pm
ONe more of the trials. http://abstracts.asco.org/214/AbstView_214_227491.html
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- September 17, 2018 at 2:30 pm
Thanks Ed for your research!!We will wait and see if the biopsy results show the her-2 mutation and anything else. Hopefully, surgery is an option too. Our biggest concern is to have a dangerous reaction to any drug choices.
Maureen
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Tagged: acral, cutaneous melanoma
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