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Two More Questions/WLE of Metastasis, In-Transit
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Two More Questions/WLE of Metastasis, In-Transit

› Forums › General Melanoma Community › Two More Questions/WLE of Metastasis, In-Transit

  • Post
    • October 16, 2014 at 12:34 pm
    Girl52
    Participant

      Have more questions as family awaits brother-in-law's results. I am a writer/reporter by profession so always have loads of detailed questions….thanks for your patience.

      *Have read that WLE of a metastatic lesion or recurrent tumor has different guidelines than does excision of a primary/first-time tumor. Does anyone know what is done differently? Different margins, some different analysis of tissue?

      *Why is in-transit metastasis defined as "late-stage disease" if it is regional and non-nodal, as I've read? Wouldn't surgery to remove tumor and adjacent lymphatic vessels be curative? Or, as in other scenarios, is the danger that other regional lymphatic vessels have been affected and are left behind in the surgery?    

    Viewing 5 reply threads
    • Replies
        • October 16, 2014 at 3:39 pm
        ed williams
        Participant

          Hi Girl52, I just finished watching a series on OncLive ( go to Onclive : select Melanoma on left tiltles then select picture of Dr. Jeffrey Weber, guy with bow tie. He is one of the leading Melanoma specialist in the US.  The title under his picture is Nivolumab Plus Ipilimumab in Advanced Melanoma. You now have video with text below it, if you go down page you will find a list of 12 episodes with a top field of medical oncologist and surgeons from across the US. The different episode cover a wide range of Melanoma topics published in Oct. of 2014. They use current data and findings from 2014 ASCO and talk about pros and cons of different procedures. Episode 1 and 2 talk about Surgical Excision of Melanoma and SLN biopsy and Imaging. Hope it will be of some help to you. Ed

            • October 16, 2014 at 5:21 pm
            Girl52
            Participant

              Ed: You're the best…thank you. Sounds like this series will give me plenty of detail. The more I know, the easier I tend to feel. Will start watching now.

              • October 16, 2014 at 5:21 pm
              Girl52
              Participant

                Ed: You're the best…thank you. Sounds like this series will give me plenty of detail. The more I know, the easier I tend to feel. Will start watching now.

                • October 16, 2014 at 5:21 pm
                Girl52
                Participant

                  Ed: You're the best…thank you. Sounds like this series will give me plenty of detail. The more I know, the easier I tend to feel. Will start watching now.

                • October 16, 2014 at 3:39 pm
                ed williams
                Participant

                  Hi Girl52, I just finished watching a series on OncLive ( go to Onclive : select Melanoma on left tiltles then select picture of Dr. Jeffrey Weber, guy with bow tie. He is one of the leading Melanoma specialist in the US.  The title under his picture is Nivolumab Plus Ipilimumab in Advanced Melanoma. You now have video with text below it, if you go down page you will find a list of 12 episodes with a top field of medical oncologist and surgeons from across the US. The different episode cover a wide range of Melanoma topics published in Oct. of 2014. They use current data and findings from 2014 ASCO and talk about pros and cons of different procedures. Episode 1 and 2 talk about Surgical Excision of Melanoma and SLN biopsy and Imaging. Hope it will be of some help to you. Ed

                  • October 16, 2014 at 3:39 pm
                  ed williams
                  Participant

                    Hi Girl52, I just finished watching a series on OncLive ( go to Onclive : select Melanoma on left tiltles then select picture of Dr. Jeffrey Weber, guy with bow tie. He is one of the leading Melanoma specialist in the US.  The title under his picture is Nivolumab Plus Ipilimumab in Advanced Melanoma. You now have video with text below it, if you go down page you will find a list of 12 episodes with a top field of medical oncologist and surgeons from across the US. The different episode cover a wide range of Melanoma topics published in Oct. of 2014. They use current data and findings from 2014 ASCO and talk about pros and cons of different procedures. Episode 1 and 2 talk about Surgical Excision of Melanoma and SLN biopsy and Imaging. Hope it will be of some help to you. Ed

                    • October 17, 2014 at 4:21 pm
                    Bubbles
                    Participant

                      Dear Sis-in-law….Sorry for your brother.  Intransit mel is a tough row in the already tough field of melanoma.  It occurs in about 10% of melanoma patients.  Isolated limb perfusion has been helpful for some.  You may have already read this….but perhaps this link will give you some additional info if you haven't:  http://www.intechopen.com/books/melanoma-from-early-detection-to-treatment/management-of-in-transit-malignant-melanoma

                      Also an article just came out:  In-transit melanoma metastasis: Incidence, Prognosis and Role of Lymphadenectomy.  Read, Haydu, Saw, et al.  Ann Surg Oncol. 2014 Sep 26.  WIll be putting it up on my blog soon….but you can probably find it.  Sorry I don't have the link just now.  I think you can email me through this site and I can send you a copy if you can't find it and are interested.

                      Wishing you and yours my best.  Celeste

                        • October 17, 2014 at 5:32 pm
                        Girl52
                        Participant

                          Celeste: Thank you….I appreciate it. Will read if I can find. My BIL hasn't been diagnosed with in-transit, but surgeon said he'd be checking for it. Hoping the results will be available by early next week. Hope your weekend is good.  

                          • October 17, 2014 at 6:23 pm
                          Bubbles
                          Participant

                            Ok…was confused.  I wondered how he could have that diagnosis already.  It is good that the surgeon is aware of the possibility…we are learning that the earliest possible diagnosis is better….though the average time between diagnosis of the primary melanoma lesion and in-transit melanoma is about 18 months. Very much hoping that all goes well for him.  Yours, Celeste

                            • October 17, 2014 at 6:23 pm
                            Bubbles
                            Participant

                              Ok…was confused.  I wondered how he could have that diagnosis already.  It is good that the surgeon is aware of the possibility…we are learning that the earliest possible diagnosis is better….though the average time between diagnosis of the primary melanoma lesion and in-transit melanoma is about 18 months. Very much hoping that all goes well for him.  Yours, Celeste

                              • October 17, 2014 at 6:23 pm
                              Bubbles
                              Participant

                                Ok…was confused.  I wondered how he could have that diagnosis already.  It is good that the surgeon is aware of the possibility…we are learning that the earliest possible diagnosis is better….though the average time between diagnosis of the primary melanoma lesion and in-transit melanoma is about 18 months. Very much hoping that all goes well for him.  Yours, Celeste

                                • October 17, 2014 at 5:32 pm
                                Girl52
                                Participant

                                  Celeste: Thank you….I appreciate it. Will read if I can find. My BIL hasn't been diagnosed with in-transit, but surgeon said he'd be checking for it. Hoping the results will be available by early next week. Hope your weekend is good.  

                                  • October 17, 2014 at 5:32 pm
                                  Girl52
                                  Participant

                                    Celeste: Thank you….I appreciate it. Will read if I can find. My BIL hasn't been diagnosed with in-transit, but surgeon said he'd be checking for it. Hoping the results will be available by early next week. Hope your weekend is good.  

                                  • October 17, 2014 at 4:21 pm
                                  Bubbles
                                  Participant

                                    Dear Sis-in-law….Sorry for your brother.  Intransit mel is a tough row in the already tough field of melanoma.  It occurs in about 10% of melanoma patients.  Isolated limb perfusion has been helpful for some.  You may have already read this….but perhaps this link will give you some additional info if you haven't:  http://www.intechopen.com/books/melanoma-from-early-detection-to-treatment/management-of-in-transit-malignant-melanoma

                                    Also an article just came out:  In-transit melanoma metastasis: Incidence, Prognosis and Role of Lymphadenectomy.  Read, Haydu, Saw, et al.  Ann Surg Oncol. 2014 Sep 26.  WIll be putting it up on my blog soon….but you can probably find it.  Sorry I don't have the link just now.  I think you can email me through this site and I can send you a copy if you can't find it and are interested.

                                    Wishing you and yours my best.  Celeste

                                    • October 17, 2014 at 4:21 pm
                                    Bubbles
                                    Participant

                                      Dear Sis-in-law….Sorry for your brother.  Intransit mel is a tough row in the already tough field of melanoma.  It occurs in about 10% of melanoma patients.  Isolated limb perfusion has been helpful for some.  You may have already read this….but perhaps this link will give you some additional info if you haven't:  http://www.intechopen.com/books/melanoma-from-early-detection-to-treatment/management-of-in-transit-malignant-melanoma

                                      Also an article just came out:  In-transit melanoma metastasis: Incidence, Prognosis and Role of Lymphadenectomy.  Read, Haydu, Saw, et al.  Ann Surg Oncol. 2014 Sep 26.  WIll be putting it up on my blog soon….but you can probably find it.  Sorry I don't have the link just now.  I think you can email me through this site and I can send you a copy if you can't find it and are interested.

                                      Wishing you and yours my best.  Celeste

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