TIL

Wow. That must be devestating. zel, ipi, taf/mek all failed me at the first scan. Fortunately merck's pd1 is having some results. They say I'm a mixed responder but there are lots more shrinking than are growing. After the first scan they are still keeping me on it.

So yeah if pd1 did not work my plan b was Dr. Rosenberg's TIL/ACT stuff.

Here's a link to a pretty good article on it:

http://www.cancer.gov/ncicancerbulletin/050112/page4

I really liked this part of the article:

"The results to date are impressive. Of the 93 patients treated in the three trials, 20 have seen their tumors disappear completely (complete response); 19 of those 20 have remained tumor-free for longer than 5 years. (Most of these patients' tumors had not responded to other immunotherapy treatments.) Overall, tumors shrank substantially in 52 patients."

Search here did not show it for me but there was quite a lot of talk about people having been on it here I think back in June. Of course everyone is different but those numbers seem pretty good to me if I read it right. About a 50/50 chance of being a responder is pretty good with this stuff I think. Of course 100% would be ideal.

Like someone here said to me when every medicine was failing you gotta stay strong and get to that next treatment. You only have to find that one that will work for you.

Good luck to you Inger.

Artie

Wow. That must be devestating. zel, ipi, taf/mek all failed me at the first scan. Fortunately merck's pd1 is having some results. They say I'm a mixed responder but there are lots more shrinking than are growing. After the first scan they are still keeping me on it.

So yeah if pd1 did not work my plan b was Dr. Rosenberg's TIL/ACT stuff.

Here's a link to a pretty good article on it:

http://www.cancer.gov/ncicancerbulletin/050112/page4

I really liked this part of the article:

"The results to date are impressive. Of the 93 patients treated in the three trials, 20 have seen their tumors disappear completely (complete response); 19 of those 20 have remained tumor-free for longer than 5 years. (Most of these patients' tumors had not responded to other immunotherapy treatments.) Overall, tumors shrank substantially in 52 patients."

Search here did not show it for me but there was quite a lot of talk about people having been on it here I think back in June. Of course everyone is different but those numbers seem pretty good to me if I read it right. About a 50/50 chance of being a responder is pretty good with this stuff I think. Of course 100% would be ideal.

Like someone here said to me when every medicine was failing you gotta stay strong and get to that next treatment. You only have to find that one that will work for you.

Good luck to you Inger.

Artie

Wow. That must be devestating. zel, ipi, taf/mek all failed me at the first scan. Fortunately merck's pd1 is having some results. They say I'm a mixed responder but there are lots more shrinking than are growing. After the first scan they are still keeping me on it.

So yeah if pd1 did not work my plan b was Dr. Rosenberg's TIL/ACT stuff.

Here's a link to a pretty good article on it:

http://www.cancer.gov/ncicancerbulletin/050112/page4

I really liked this part of the article:

"The results to date are impressive. Of the 93 patients treated in the three trials, 20 have seen their tumors disappear completely (complete response); 19 of those 20 have remained tumor-free for longer than 5 years. (Most of these patients' tumors had not responded to other immunotherapy treatments.) Overall, tumors shrank substantially in 52 patients."

Search here did not show it for me but there was quite a lot of talk about people having been on it here I think back in June. Of course everyone is different but those numbers seem pretty good to me if I read it right. About a 50/50 chance of being a responder is pretty good with this stuff I think. Of course 100% would be ideal.

Like someone here said to me when every medicine was failing you gotta stay strong and get to that next treatment. You only have to find that one that will work for you.

Good luck to you Inger.

Artie

So sorry you are dealing with this,

I heard from some people thag after other inmunotheraphy had a great succes, even complete and durable responses.

Hang it there

Any of you know how much this treatment cost?

So sorry you are dealing with this,

I heard from some people thag after other inmunotheraphy had a great succes, even complete and durable responses.

Hang it there

Any of you know how much this treatment cost?

So sorry you are dealing with this,

I heard from some people thag after other inmunotheraphy had a great succes, even complete and durable responses.

Hang it there

Any of you know how much this treatment cost?

Hello, sorry to hear that you haven't had results from either ipi or nivo.  I was in a TIL trial at NIH back in 2010-11 and had a partial response.  In the weeks following treatment, I could see in the mirror the one visible tumor I had (in the soft tissue outside my skull in my right temple) literally melt away and it and the other two active tumors I had at the time (on my internal chest wall and left underarm) both responded completely within about 3 months.   I eventually had disease progression, mostly in the "long bones" of my legs, femur and tibia, but my doctors all believe that the TIL has played an ongoing role in slowing progression so we've been able to address metastases with radiation and/or surgery.  My TIL story is a little complicated, but it was essentially the first treatment I tried after I was diagnosed at Stage IV in the summer of 2010 — neither ipi or the BRAF inhibitors had been approved and nivo wasn't even in trials then.  

I'm glad to answer any questions you have about TIL or NIH, I'll keep an eye on this thread for other questions.  I'm not sure him much detail you'd like and as I said, my case has been complicated, lots of twists and turns, so documenting it in a single post would be hard.  But I consider that I had a good response to TIL and knowing what I know now, I would go through it again.

Joe

Hello, sorry to hear that you haven't had results from either ipi or nivo.  I was in a TIL trial at NIH back in 2010-11 and had a partial response.  In the weeks following treatment, I could see in the mirror the one visible tumor I had (in the soft tissue outside my skull in my right temple) literally melt away and it and the other two active tumors I had at the time (on my internal chest wall and left underarm) both responded completely within about 3 months.   I eventually had disease progression, mostly in the "long bones" of my legs, femur and tibia, but my doctors all believe that the TIL has played an ongoing role in slowing progression so we've been able to address metastases with radiation and/or surgery.  My TIL story is a little complicated, but it was essentially the first treatment I tried after I was diagnosed at Stage IV in the summer of 2010 — neither ipi or the BRAF inhibitors had been approved and nivo wasn't even in trials then.  

I'm glad to answer any questions you have about TIL or NIH, I'll keep an eye on this thread for other questions.  I'm not sure him much detail you'd like and as I said, my case has been complicated, lots of twists and turns, so documenting it in a single post would be hard.  But I consider that I had a good response to TIL and knowing what I know now, I would go through it again.

Joe

Hello, sorry to hear that you haven't had results from either ipi or nivo.  I was in a TIL trial at NIH back in 2010-11 and had a partial response.  In the weeks following treatment, I could see in the mirror the one visible tumor I had (in the soft tissue outside my skull in my right temple) literally melt away and it and the other two active tumors I had at the time (on my internal chest wall and left underarm) both responded completely within about 3 months.   I eventually had disease progression, mostly in the "long bones" of my legs, femur and tibia, but my doctors all believe that the TIL has played an ongoing role in slowing progression so we've been able to address metastases with radiation and/or surgery.  My TIL story is a little complicated, but it was essentially the first treatment I tried after I was diagnosed at Stage IV in the summer of 2010 — neither ipi or the BRAF inhibitors had been approved and nivo wasn't even in trials then.  

I'm glad to answer any questions you have about TIL or NIH, I'll keep an eye on this thread for other questions.  I'm not sure him much detail you'd like and as I said, my case has been complicated, lots of twists and turns, so documenting it in a single post would be hard.  But I consider that I had a good response to TIL and knowing what I know now, I would go through it again.

Joe