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TIL Update, MEK Question
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TIL Update, MEK Question

› Forums › General Melanoma Community › TIL Update, MEK Question

  • Post
    • August 15, 2012 at 1:48 pm
    Angela C
    Participant

      Hi everyone.

      Yesterday I got the results of my scans four months out from IL-12 TIL at NIH. Scans have been stable the last three months. This time there was a small amount of growth, about .7cm. They said they have seen tumors grow one month and shrink the next, so they haven't written this treatment off as a failure for me yet.

      Hi everyone.

      Yesterday I got the results of my scans four months out from IL-12 TIL at NIH. Scans have been stable the last three months. This time there was a small amount of growth, about .7cm. They said they have seen tumors grow one month and shrink the next, so they haven't written this treatment off as a failure for me yet.

      However, they want me to start doing my research into the possible next step, should September's scans still show growth. I am BRAF negative and have pretty much done every treatment that is available. They suggested looking into a MEK inhibitor trial, but for someone without the BRAF mutation. We are told that there are some places doing this. I'm not familiar at all with MEK. Does anyone have any experience or insight into this treatment for someone without the BRAF mutation?

      Thanks!

      ~Angela

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    • Replies
        • August 16, 2012 at 1:16 am
        melissa ann
        Participant

          HI Angela, it seems like you and my husband are on very similiar melanoma treatment regimens.  Actually, he was being evaluated at NIH for TILS at the same time you were accepted.  Unfortunately, he was not accepted.  We went on to Moffitt for BMS Anti-PD1.  Unfortunately he did not respond to that either.  Anyway, Dr. Weber at Moffitt recommended that we go to MD Anderson and speak to Dr. Gerald Falchook in the targeted therapy department about a MEK trial for patients with out the BRAF mutation.  We have not done that yet, we are conferring with our docs in Charlotte.  Actually, we may be heading to MDA for another TILS evaluation with Dr Hwu next week. Never a dull  moment, as I am sure you know.  I hope this info is helpful to you, peace and good thoughts to you!   My e-mail is [email protected] if you want further information.    🙂 Melissa

          • August 16, 2012 at 1:16 am
          melissa ann
          Participant

            HI Angela, it seems like you and my husband are on very similiar melanoma treatment regimens.  Actually, he was being evaluated at NIH for TILS at the same time you were accepted.  Unfortunately, he was not accepted.  We went on to Moffitt for BMS Anti-PD1.  Unfortunately he did not respond to that either.  Anyway, Dr. Weber at Moffitt recommended that we go to MD Anderson and speak to Dr. Gerald Falchook in the targeted therapy department about a MEK trial for patients with out the BRAF mutation.  We have not done that yet, we are conferring with our docs in Charlotte.  Actually, we may be heading to MDA for another TILS evaluation with Dr Hwu next week. Never a dull  moment, as I am sure you know.  I hope this info is helpful to you, peace and good thoughts to you!   My e-mail is [email protected] if you want further information.    🙂 Melissa

            • August 16, 2012 at 1:16 am
            melissa ann
            Participant

              HI Angela, it seems like you and my husband are on very similiar melanoma treatment regimens.  Actually, he was being evaluated at NIH for TILS at the same time you were accepted.  Unfortunately, he was not accepted.  We went on to Moffitt for BMS Anti-PD1.  Unfortunately he did not respond to that either.  Anyway, Dr. Weber at Moffitt recommended that we go to MD Anderson and speak to Dr. Gerald Falchook in the targeted therapy department about a MEK trial for patients with out the BRAF mutation.  We have not done that yet, we are conferring with our docs in Charlotte.  Actually, we may be heading to MDA for another TILS evaluation with Dr Hwu next week. Never a dull  moment, as I am sure you know.  I hope this info is helpful to you, peace and good thoughts to you!   My e-mail is [email protected] if you want further information.    🙂 Melissa

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