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TIL Treatment without IL-2

Forums General Melanoma Community TIL Treatment without IL-2

  • Post
    ncdaniel
    Participant

      Has anyone had TIL treatment without the IL-2 to follow? Does anyone have a good or bad story to share as my wife considers this treatment option. I know in most cases the TIL is done with Chemo and Radiation plus IL-2  but in this case it would be only chemo and the Til cell transfer. any comments are more than welcomed.

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    • Replies
        Jeff G.
        Participant

          Yes.  My wife went through a TIL treatment at NCI that did not include IL-2 at the end.  Her cells were, however, genetically engineered to express IL-12 so it was a bit different.  That trial closed because unfortunately some patients had very severe side effects (fortunately not my wife).   Her doctors at NCI have told us there are trials underway without the IL-2 at the end of the treatment.  Most TIL treatment options do not include radiation, and those that do usually only half of the patients are receiving it so I wouldn’t worry about that.  My wife is over a year NED so it has certainly worked for her so far.  You can read about her experience at http://www.melanomamom.com.  Where are you considering the TIL treatment?

            ncdaniel
            Participant

              Thank you for your response. My wife starts treatment at NIH next week. Thanks for your encouragement I hope your wife continues to be NED.

              daniel

              ncdaniel
              Participant

                Thank you for your response. My wife starts treatment at NIH next week. Thanks for your encouragement I hope your wife continues to be NED.

                daniel

                ncdaniel
                Participant

                  Thank you for your response. My wife starts treatment at NIH next week. Thanks for your encouragement I hope your wife continues to be NED.

                  daniel

                Jeff G.
                Participant

                  Yes.  My wife went through a TIL treatment at NCI that did not include IL-2 at the end.  Her cells were, however, genetically engineered to express IL-12 so it was a bit different.  That trial closed because unfortunately some patients had very severe side effects (fortunately not my wife).   Her doctors at NCI have told us there are trials underway without the IL-2 at the end of the treatment.  Most TIL treatment options do not include radiation, and those that do usually only half of the patients are receiving it so I wouldn’t worry about that.  My wife is over a year NED so it has certainly worked for her so far.  You can read about her experience at http://www.melanomamom.com.  Where are you considering the TIL treatment?

                  Jeff G.
                  Participant

                    Yes.  My wife went through a TIL treatment at NCI that did not include IL-2 at the end.  Her cells were, however, genetically engineered to express IL-12 so it was a bit different.  That trial closed because unfortunately some patients had very severe side effects (fortunately not my wife).   Her doctors at NCI have told us there are trials underway without the IL-2 at the end of the treatment.  Most TIL treatment options do not include radiation, and those that do usually only half of the patients are receiving it so I wouldn’t worry about that.  My wife is over a year NED so it has certainly worked for her so far.  You can read about her experience at http://www.melanomamom.com.  Where are you considering the TIL treatment?

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