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TIL – Do MD Anderson and Moffitt’s results compare to NIH??
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TIL – Do MD Anderson and Moffitt’s results compare to NIH??

› Forums › General Melanoma Community › TIL – Do MD Anderson and Moffitt’s results compare to NIH??

  • Post
    • February 28, 2012 at 4:37 pm
    Angela C
    Participant

      Hello.

      I had a consult at NIH last week. They wanted to put me in the TIL plus TBI trial. I just found out that I don't qualify because of my prior radiation history. So, now I have to decide between doing the TIL + IL-12 trial at NIH or going to Moffitt or MD Anderson and doing their TIL protocol.

      NIH wasn't sure if MD Anderson and Moffitt were getting the same results that they have been able to get with TIL. They had heard that they may be having trouble growing the TIL cells. Does anyone know anything about this??

      Hello.

      I had a consult at NIH last week. They wanted to put me in the TIL plus TBI trial. I just found out that I don't qualify because of my prior radiation history. So, now I have to decide between doing the TIL + IL-12 trial at NIH or going to Moffitt or MD Anderson and doing their TIL protocol.

      NIH wasn't sure if MD Anderson and Moffitt were getting the same results that they have been able to get with TIL. They had heard that they may be having trouble growing the TIL cells. Does anyone know anything about this??

      I'm really not sure what to do. It's so hard to make these decisions sometimes.

      Thanks!!

      ~Angela

    Viewing 5 reply threads
    • Replies
        • February 28, 2012 at 6:35 pm
        jag
        Participant

          Ask NIH what results they have been gettting (long term) I would put that treatment much lower on the list of treatment options I would consider.  MD Anderson and Moffitt aren't likely the problem with this treatment.  I have payed attention to this site over the years and haven't seen Any long term remission from TIL.  Have you considered other options/trials?

          • February 28, 2012 at 6:35 pm
          jag
          Participant

            Ask NIH what results they have been gettting (long term) I would put that treatment much lower on the list of treatment options I would consider.  MD Anderson and Moffitt aren't likely the problem with this treatment.  I have payed attention to this site over the years and haven't seen Any long term remission from TIL.  Have you considered other options/trials?

              • February 28, 2012 at 6:39 pm
              Angela C
              Participant

                I have pretty much done everything that there is to offer. I've done IL-2, MDX-1106 and Yervoy. TIL is the next thing in line. NIH is having 70% response rates with TIL plus Total Body Irradiation and 50% response rates with standard TIL. So, I'm just wondering if MD Anderson and Moffitt are also getting those 50% response rates.

                • February 28, 2012 at 8:25 pm
                Phil S
                Participant
                  Angela, Feel free to email me directly, [email protected] my husband is a patient at md Anderson and is being considered for the TIL program here. From what I understand they have two cohorts here, depending on your HLAA2 status, so you need to be positive to get the TIL with vaccine arm. My husband’s cells grew fine, and they are also saying 50 percent response rate, my real concern is for durable response! Dr Patrick Hwu, who is running the adoptive cell trial in Houston, was at NIH before, he heads the melanoma department at md Anderson now, and I have ever confidence he knows how to run a adoptive cell program. Real question is who is getting a durable response! Too early to tell! Good luck to you, Valerie (Phil’s wife)
                  • February 28, 2012 at 10:25 pm
                  boot2aboot
                  Participant

                    http://www.melanomaintl.org/news/webinar_adoptive1.html

                     

                    very good webinar…Weber goes through differences of protocol between NIH and Moffitt. and percentages of CR adn PR with TIL/ACT.  I do believe that one cohort does not have to be HLA-A2(this is NOT mentioned in Webinar)at Moffitt, but will find out more when i go down there on the M 30th…i think Moffitt gets comparable results to anderson and NCI…but treatment not as rough…doesn't knock out whole immune system and considering doing the Anti-PD1 as Tcell stimulator as opposed to IL2…i always kinda was leary of NIH's TIL therapy after Val's experience…i thought it was TOO ROUGH…i do know that there are some (not on this board) that got NED through NIH on this protocol

                    good luck

                    boots

                    • February 28, 2012 at 10:25 pm
                    boot2aboot
                    Participant

                      http://www.melanomaintl.org/news/webinar_adoptive1.html

                       

                      very good webinar…Weber goes through differences of protocol between NIH and Moffitt. and percentages of CR adn PR with TIL/ACT.  I do believe that one cohort does not have to be HLA-A2(this is NOT mentioned in Webinar)at Moffitt, but will find out more when i go down there on the M 30th…i think Moffitt gets comparable results to anderson and NCI…but treatment not as rough…doesn't knock out whole immune system and considering doing the Anti-PD1 as Tcell stimulator as opposed to IL2…i always kinda was leary of NIH's TIL therapy after Val's experience…i thought it was TOO ROUGH…i do know that there are some (not on this board) that got NED through NIH on this protocol

                      good luck

                      boots

                      • February 28, 2012 at 10:25 pm
                      boot2aboot
                      Participant

                        http://www.melanomaintl.org/news/webinar_adoptive1.html

                         

                        very good webinar…Weber goes through differences of protocol between NIH and Moffitt. and percentages of CR adn PR with TIL/ACT.  I do believe that one cohort does not have to be HLA-A2(this is NOT mentioned in Webinar)at Moffitt, but will find out more when i go down there on the M 30th…i think Moffitt gets comparable results to anderson and NCI…but treatment not as rough…doesn't knock out whole immune system and considering doing the Anti-PD1 as Tcell stimulator as opposed to IL2…i always kinda was leary of NIH's TIL therapy after Val's experience…i thought it was TOO ROUGH…i do know that there are some (not on this board) that got NED through NIH on this protocol

                        good luck

                        boots

                        • February 28, 2012 at 10:29 pm
                        boot2aboot
                        Participant

                          have you ever thought of cyber knife to adrenal tumor?

                          boots

                          • February 28, 2012 at 10:29 pm
                          boot2aboot
                          Participant

                            have you ever thought of cyber knife to adrenal tumor?

                            boots

                            • February 28, 2012 at 10:29 pm
                            boot2aboot
                            Participant

                              have you ever thought of cyber knife to adrenal tumor?

                              boots

                              • February 28, 2012 at 8:25 pm
                              Phil S
                              Participant
                                Angela, Feel free to email me directly, [email protected] my husband is a patient at md Anderson and is being considered for the TIL program here. From what I understand they have two cohorts here, depending on your HLAA2 status, so you need to be positive to get the TIL with vaccine arm. My husband’s cells grew fine, and they are also saying 50 percent response rate, my real concern is for durable response! Dr Patrick Hwu, who is running the adoptive cell trial in Houston, was at NIH before, he heads the melanoma department at md Anderson now, and I have ever confidence he knows how to run a adoptive cell program. Real question is who is getting a durable response! Too early to tell! Good luck to you, Valerie (Phil’s wife)
                                • February 28, 2012 at 8:25 pm
                                Phil S
                                Participant
                                  Angela, Feel free to email me directly, [email protected] my husband is a patient at md Anderson and is being considered for the TIL program here. From what I understand they have two cohorts here, depending on your HLAA2 status, so you need to be positive to get the TIL with vaccine arm. My husband’s cells grew fine, and they are also saying 50 percent response rate, my real concern is for durable response! Dr Patrick Hwu, who is running the adoptive cell trial in Houston, was at NIH before, he heads the melanoma department at md Anderson now, and I have ever confidence he knows how to run a adoptive cell program. Real question is who is getting a durable response! Too early to tell! Good luck to you, Valerie (Phil’s wife)
                                  • February 28, 2012 at 6:39 pm
                                  Angela C
                                  Participant

                                    I have pretty much done everything that there is to offer. I've done IL-2, MDX-1106 and Yervoy. TIL is the next thing in line. NIH is having 70% response rates with TIL plus Total Body Irradiation and 50% response rates with standard TIL. So, I'm just wondering if MD Anderson and Moffitt are also getting those 50% response rates.

                                    • February 28, 2012 at 6:39 pm
                                    Angela C
                                    Participant

                                      I have pretty much done everything that there is to offer. I've done IL-2, MDX-1106 and Yervoy. TIL is the next thing in line. NIH is having 70% response rates with TIL plus Total Body Irradiation and 50% response rates with standard TIL. So, I'm just wondering if MD Anderson and Moffitt are also getting those 50% response rates.

                                    • February 28, 2012 at 6:35 pm
                                    jag
                                    Participant

                                      Ask NIH what results they have been gettting (long term) I would put that treatment much lower on the list of treatment options I would consider.  MD Anderson and Moffitt aren't likely the problem with this treatment.  I have payed attention to this site over the years and haven't seen Any long term remission from TIL.  Have you considered other options/trials?

                                      • February 29, 2012 at 4:11 pm
                                      cltml
                                      Participant

                                        Angela,

                                        I was seen by Dr. Weber two weeks ago at Moffitt for consideration for ACT.  Dr. Weber is/was getting the 50% response that NIH was getting with ACT&IL2.  NIH has switched to using IL15 recently but only have a half dozen patients or so as of my conversation with Dr. M. Hughes.  Of course, NIH has so many trials.

                                        Unfortunately, Dr. Weber indicated that Moffitt is out of donor money for the TIL generation part of their ACT treatment so unless you can pay for that yourself, they will probably tell you they cannot do it until they get more $'s.

                                        My info was current as of March 17th, 22012.

                                        • February 29, 2012 at 4:11 pm
                                        cltml
                                        Participant

                                          Angela,

                                          I was seen by Dr. Weber two weeks ago at Moffitt for consideration for ACT.  Dr. Weber is/was getting the 50% response that NIH was getting with ACT&IL2.  NIH has switched to using IL15 recently but only have a half dozen patients or so as of my conversation with Dr. M. Hughes.  Of course, NIH has so many trials.

                                          Unfortunately, Dr. Weber indicated that Moffitt is out of donor money for the TIL generation part of their ACT treatment so unless you can pay for that yourself, they will probably tell you they cannot do it until they get more $'s.

                                          My info was current as of March 17th, 22012.

                                          • February 29, 2012 at 4:11 pm
                                          cltml
                                          Participant

                                            Angela,

                                            I was seen by Dr. Weber two weeks ago at Moffitt for consideration for ACT.  Dr. Weber is/was getting the 50% response that NIH was getting with ACT&IL2.  NIH has switched to using IL15 recently but only have a half dozen patients or so as of my conversation with Dr. M. Hughes.  Of course, NIH has so many trials.

                                            Unfortunately, Dr. Weber indicated that Moffitt is out of donor money for the TIL generation part of their ACT treatment so unless you can pay for that yourself, they will probably tell you they cannot do it until they get more $'s.

                                            My info was current as of March 17th, 22012.

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