three doses of ipi

I too developed colitis after 3 doses of Ipi. As hard as it is to believe right now, you do NOT want the 4th dose. Your body is at its maximum ipi immune system response. The only thing that cured my colitis was 2 doses of Remicade–you might want to discuss that with your oncologist so you can start weaning off the steroids.
I was only a partial and short-lived responder to Ipi, which is why I’m awaiting the start of an anti-PD1 trial. I do know that PD1 after Ipi is supposed to produce good results. Catherine at melanoma international is great at finding clinical trials for folks in various countries.
I’m so sorry you’re going through this; I hope you’ll keep us posted.
Karen

I too developed colitis after 3 doses of Ipi. As hard as it is to believe right now, you do NOT want the 4th dose. Your body is at its maximum ipi immune system response. The only thing that cured my colitis was 2 doses of Remicade–you might want to discuss that with your oncologist so you can start weaning off the steroids.
I was only a partial and short-lived responder to Ipi, which is why I’m awaiting the start of an anti-PD1 trial. I do know that PD1 after Ipi is supposed to produce good results. Catherine at melanoma international is great at finding clinical trials for folks in various countries.
I’m so sorry you’re going through this; I hope you’ll keep us posted.
Karen

I too developed colitis after 3 doses of Ipi. As hard as it is to believe right now, you do NOT want the 4th dose. Your body is at its maximum ipi immune system response. The only thing that cured my colitis was 2 doses of Remicade–you might want to discuss that with your oncologist so you can start weaning off the steroids.
I was only a partial and short-lived responder to Ipi, which is why I’m awaiting the start of an anti-PD1 trial. I do know that PD1 after Ipi is supposed to produce good results. Catherine at melanoma international is great at finding clinical trials for folks in various countries.
I’m so sorry you’re going through this; I hope you’ll keep us posted.
Karen

Having an auto-immune response to the ipi is actually a good sign. It shows, as my Dr explained to me, that the ipi has done what it was supposed to and got the immune system ramped up. I can imagine these past weeks have been exhausitng for you, and hoping you have begun to recover. Will look forward to hearing results of your scans. Initial scans do not always show what the ultimate outcome will be, either… because it can take a little time for the ipi to show its effect.

Tina

Having an auto-immune response to the ipi is actually a good sign. It shows, as my Dr explained to me, that the ipi has done what it was supposed to and got the immune system ramped up. I can imagine these past weeks have been exhausitng for you, and hoping you have begun to recover. Will look forward to hearing results of your scans. Initial scans do not always show what the ultimate outcome will be, either… because it can take a little time for the ipi to show its effect.

Tina

Having an auto-immune response to the ipi is actually a good sign. It shows, as my Dr explained to me, that the ipi has done what it was supposed to and got the immune system ramped up. I can imagine these past weeks have been exhausitng for you, and hoping you have begun to recover. Will look forward to hearing results of your scans. Initial scans do not always show what the ultimate outcome will be, either… because it can take a little time for the ipi to show its effect.

Tina

The colitis can be treated. To go on the PD-1 trial either Merck or BMS you have to be 4-6 weeks from WBR. My wife has currently dealt with this. She did complete IPI and also had to have WBR after. It does show a good response so far patient that have had IPI then get on one of the PD-1 trials. good luck and keep pushing. following the comments on here will give you some good things to question and look up. 

The colitis can be treated. To go on the PD-1 trial either Merck or BMS you have to be 4-6 weeks from WBR. My wife has currently dealt with this. She did complete IPI and also had to have WBR after. It does show a good response so far patient that have had IPI then get on one of the PD-1 trials. good luck and keep pushing. following the comments on here will give you some good things to question and look up. 

The colitis can be treated. To go on the PD-1 trial either Merck or BMS you have to be 4-6 weeks from WBR. My wife has currently dealt with this. She did complete IPI and also had to have WBR after. It does show a good response so far patient that have had IPI then get on one of the PD-1 trials. good luck and keep pushing. following the comments on here will give you some good things to question and look up. 

Just to be clear…you do NOT have to have whole brain radiation to be in an anti-PD1 trial.  You will have to deal with the brain mets…the options include:  whole brain radiation, stereotactic radiation, surgery, or resolution just because…which ipi can sometimes help induce…and remain stable for a certain amount of time….before being admitted into an anti-PD1 trial.  Trust me. I had a brain met and have completed and  a 2 1/2 year anti-PD1 trial and remain NED.  With 40 brain mets….you are up against a formidable enemy.  BUT…whole brain radiation is not REQUIRED!!!!  You do have to deal with the mets in some way…and then have to go through a period of stability…but there are many ways to get there.  Wishing you the best.  Celeste

Just to be clear…you do NOT have to have whole brain radiation to be in an anti-PD1 trial.  You will have to deal with the brain mets…the options include:  whole brain radiation, stereotactic radiation, surgery, or resolution just because…which ipi can sometimes help induce…and remain stable for a certain amount of time….before being admitted into an anti-PD1 trial.  Trust me. I had a brain met and have completed and  a 2 1/2 year anti-PD1 trial and remain NED.  With 40 brain mets….you are up against a formidable enemy.  BUT…whole brain radiation is not REQUIRED!!!!  You do have to deal with the mets in some way…and then have to go through a period of stability…but there are many ways to get there.  Wishing you the best.  Celeste

Just to be clear…you do NOT have to have whole brain radiation to be in an anti-PD1 trial.  You will have to deal with the brain mets…the options include:  whole brain radiation, stereotactic radiation, surgery, or resolution just because…which ipi can sometimes help induce…and remain stable for a certain amount of time….before being admitted into an anti-PD1 trial.  Trust me. I had a brain met and have completed and  a 2 1/2 year anti-PD1 trial and remain NED.  With 40 brain mets….you are up against a formidable enemy.  BUT…whole brain radiation is not REQUIRED!!!!  You do have to deal with the mets in some way…and then have to go through a period of stability…but there are many ways to get there.  Wishing you the best.  Celeste

That is right. With Keri's brain mets the oncologist recommend WBR. Then on Merck they said 30 from radiation then scan to see if stable and now on BMS you have to be 8 weeks from radition then scan for stable. With Keri we were turned down on Merck due to hemogloban count but BMS said we are good. The only concern with BMS is that it is randomized. good luck and never give up.. 

That is right. With Keri's brain mets the oncologist recommend WBR. Then on Merck they said 30 from radiation then scan to see if stable and now on BMS you have to be 8 weeks from radition then scan for stable. With Keri we were turned down on Merck due to hemogloban count but BMS said we are good. The only concern with BMS is that it is randomized. good luck and never give up.. 

That is right. With Keri's brain mets the oncologist recommend WBR. Then on Merck they said 30 from radiation then scan to see if stable and now on BMS you have to be 8 weeks from radition then scan for stable. With Keri we were turned down on Merck due to hemogloban count but BMS said we are good. The only concern with BMS is that it is randomized. good luck and never give up..