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The most important new drug of 2015? :)
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The most important new drug of 2015? :)

› Forums › General Melanoma Community › The most important new drug of 2015? :)

  • Post
    • January 5, 2015 at 12:59 pm
    rick1981
    Participant

      ….panRAF inhibitors.

      Stage 1 trials just starting. These pills seems similar to BRAF/MEK in attacking proteins but use multiple paths making them potentially impossible to become resistent too. Promising!

      (I can't paste the link unfortunately, anyone else having issues pasting text on MPIP?!)

       

    Viewing 14 reply threads
    • Replies
        • January 5, 2015 at 2:48 pm
        Wader
        Participant

          Are there trials in the US? From what I read trials are offered in the UK.

          Hope there will be some in the US.

          • January 5, 2015 at 2:48 pm
          Wader
          Participant

            Are there trials in the US? From what I read trials are offered in the UK.

            Hope there will be some in the US.

              • January 6, 2015 at 7:56 am
              rick1981
              Participant

                There is a trial open, can't paste the link as usual but it's called LY3009120 on the clinicaltrials.gov website. The company behind the drug is Eli Lilly (?).

                They are recruiting in Boston, Scotsdale AZ and Houston.

                • January 6, 2015 at 7:56 am
                rick1981
                Participant

                  There is a trial open, can't paste the link as usual but it's called LY3009120 on the clinicaltrials.gov website. The company behind the drug is Eli Lilly (?).

                  They are recruiting in Boston, Scotsdale AZ and Houston.

                  • January 6, 2015 at 7:56 am
                  rick1981
                  Participant

                    There is a trial open, can't paste the link as usual but it's called LY3009120 on the clinicaltrials.gov website. The company behind the drug is Eli Lilly (?).

                    They are recruiting in Boston, Scotsdale AZ and Houston.

                    • January 7, 2015 at 9:07 am
                    rick1981
                    Participant

                      The trial in the UK (different one it seems) will be in the Royal Marsden in London and the Christie Hospital in Manchester – recruitment hasn't started yet.

                      • January 7, 2015 at 9:07 am
                      rick1981
                      Participant

                        The trial in the UK (different one it seems) will be in the Royal Marsden in London and the Christie Hospital in Manchester – recruitment hasn't started yet.

                        • January 7, 2015 at 9:07 am
                        rick1981
                        Participant

                          The trial in the UK (different one it seems) will be in the Royal Marsden in London and the Christie Hospital in Manchester – recruitment hasn't started yet.

                        • January 5, 2015 at 2:48 pm
                        Wader
                        Participant

                          Are there trials in the US? From what I read trials are offered in the UK.

                          Hope there will be some in the US.

                          • January 5, 2015 at 7:26 pm
                          arthurjedi007
                          Participant

                            http://www.dailymail.co.uk/health/article-2894612/Revolutionary-new-PILL-treat-skin-cancer-Scientists-discover-drug-help-patients-resistant-standard-treatments.html

                            Sounds fantastic. Hope it works. Also for the 30%ish of us that are B-RAF positive but B-RAF doesn't work I hope this works.

                            Thanks Rick.

                            Artie

                            • January 5, 2015 at 7:26 pm
                            arthurjedi007
                            Participant

                              http://www.dailymail.co.uk/health/article-2894612/Revolutionary-new-PILL-treat-skin-cancer-Scientists-discover-drug-help-patients-resistant-standard-treatments.html

                              Sounds fantastic. Hope it works. Also for the 30%ish of us that are B-RAF positive but B-RAF doesn't work I hope this works.

                              Thanks Rick.

                              Artie

                              • January 5, 2015 at 7:26 pm
                              arthurjedi007
                              Participant

                                http://www.dailymail.co.uk/health/article-2894612/Revolutionary-new-PILL-treat-skin-cancer-Scientists-discover-drug-help-patients-resistant-standard-treatments.html

                                Sounds fantastic. Hope it works. Also for the 30%ish of us that are B-RAF positive but B-RAF doesn't work I hope this works.

                                Thanks Rick.

                                Artie

                                • January 5, 2015 at 11:29 pm
                                Ninniditti
                                Participant
                                  Hi!
                                  I have read the linked page but don't understand if the new drug only works if you are BRAF positive. 
                                  • January 5, 2015 at 11:29 pm
                                  Ninniditti
                                  Participant
                                    Hi!
                                    I have read the linked page but don't understand if the new drug only works if you are BRAF positive. 
                                    • January 5, 2015 at 11:29 pm
                                    Ninniditti
                                    Participant
                                      Hi!
                                      I have read the linked page but don't understand if the new drug only works if you are BRAF positive. 
                                        • January 6, 2015 at 1:31 am
                                        arthurjedi007
                                        Participant

                                          Good question. I don't understand either.

                                          Artie

                                          • January 6, 2015 at 1:31 am
                                          arthurjedi007
                                          Participant

                                            Good question. I don't understand either.

                                            Artie

                                            • January 6, 2015 at 1:31 am
                                            arthurjedi007
                                            Participant

                                              Good question. I don't understand either.

                                              Artie

                                            • January 6, 2015 at 1:53 am
                                            Bubbles
                                            Participant

                                              PAN raf…..means that.  Covering a wide range of pathways….in theory…BRAF, NRAS, etc. Of course, time will tell. The downside may be that while they cover a greater range of pathways, they may induce a greater range of side effects as well. Of course, time will tell and we can hope.

                                              PS….to post a link? Easy peasy. Use the "chain link" icon.

                                              Here's to many new things and wonderful breakthroughs in 2015! C

                                              • January 6, 2015 at 1:53 am
                                              Bubbles
                                              Participant

                                                PAN raf…..means that.  Covering a wide range of pathways….in theory…BRAF, NRAS, etc. Of course, time will tell. The downside may be that while they cover a greater range of pathways, they may induce a greater range of side effects as well. Of course, time will tell and we can hope.

                                                PS….to post a link? Easy peasy. Use the "chain link" icon.

                                                Here's to many new things and wonderful breakthroughs in 2015! C

                                                  • January 6, 2015 at 7:46 am
                                                  rick1981
                                                  Participant

                                                    (Neither the good ol' copy-paste or the chain thingy work for me somehow – must be my old browser)

                                                    • January 6, 2015 at 7:46 am
                                                    rick1981
                                                    Participant

                                                      (Neither the good ol' copy-paste or the chain thingy work for me somehow – must be my old browser)

                                                      • January 6, 2015 at 7:46 am
                                                      rick1981
                                                      Participant

                                                        (Neither the good ol' copy-paste or the chain thingy work for me somehow – must be my old browser)

                                                        • January 6, 2015 at 11:38 am
                                                        rick1981
                                                        Participant

                                                          On the side effects, for what it's worth: "the two drugs were effective at stopping drug-resistant tumors in mice without any accompanying serious side-effects".

                                                          • January 6, 2015 at 11:38 am
                                                          rick1981
                                                          Participant

                                                            On the side effects, for what it's worth: "the two drugs were effective at stopping drug-resistant tumors in mice without any accompanying serious side-effects".

                                                            • January 6, 2015 at 11:38 am
                                                            rick1981
                                                            Participant

                                                              On the side effects, for what it's worth: "the two drugs were effective at stopping drug-resistant tumors in mice without any accompanying serious side-effects".

                                                            • January 6, 2015 at 1:53 am
                                                            Bubbles
                                                            Participant

                                                              PAN raf…..means that.  Covering a wide range of pathways….in theory…BRAF, NRAS, etc. Of course, time will tell. The downside may be that while they cover a greater range of pathways, they may induce a greater range of side effects as well. Of course, time will tell and we can hope.

                                                              PS….to post a link? Easy peasy. Use the "chain link" icon.

                                                              Here's to many new things and wonderful breakthroughs in 2015! C

                                                              • January 29, 2015 at 10:54 am
                                                              rick1981
                                                              Participant

                                                                Any news on the panRAF inhibitors? Is anyone on MPIP participating in a trial or planning to?

                                                                  • January 13, 2016 at 7:39 am
                                                                  Hibby1975
                                                                  Participant

                                                                    My husband has just started a phase 1 pan raf trial (millennium). He is struggling with some of the side effects, fatigue, joint pain and nausea. He has only had his second dose so far and he doesn't have a scan until March. It would be interesting to know if anyone has heard any more about pan raf or if anyone else is on the trial. 

                                                                    We are based in the uk.

                                                                    • January 13, 2016 at 7:39 am
                                                                    Hibby1975
                                                                    Participant

                                                                      My husband has just started a phase 1 pan raf trial (millennium). He is struggling with some of the side effects, fatigue, joint pain and nausea. He has only had his second dose so far and he doesn't have a scan until March. It would be interesting to know if anyone has heard any more about pan raf or if anyone else is on the trial. 

                                                                      We are based in the uk.

                                                                      • January 13, 2016 at 7:39 am
                                                                      Hibby1975
                                                                      Participant

                                                                        My husband has just started a phase 1 pan raf trial (millennium). He is struggling with some of the side effects, fatigue, joint pain and nausea. He has only had his second dose so far and he doesn't have a scan until March. It would be interesting to know if anyone has heard any more about pan raf or if anyone else is on the trial. 

                                                                        We are based in the uk.

                                                                      • January 29, 2015 at 10:54 am
                                                                      rick1981
                                                                      Participant

                                                                        Any news on the panRAF inhibitors? Is anyone on MPIP participating in a trial or planning to?

                                                                        • January 29, 2015 at 10:54 am
                                                                        rick1981
                                                                        Participant

                                                                          Any news on the panRAF inhibitors? Is anyone on MPIP participating in a trial or planning to?

                                                                      Viewing 14 reply threads
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