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The heat shock protein-90 inhibitor XL888 overcomes BRAF inhibitor resistance!!!
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The heat shock protein-90 inhibitor XL888 overcomes BRAF inhibitor resistance!!!

› Forums › General Melanoma Community › The heat shock protein-90 inhibitor XL888 overcomes BRAF inhibitor resistance!!!

  • Post
    • February 21, 2012 at 5:46 pm
    jim Breitfeller
    Participant

      "The clinical use of BRAF inhibitors is being hampered by the acquisition of drug resistance. This study demonstrates the potential therapeutic utility of the HSP90 inhibitor (XL888) in 6 different models of vemurafenib resistance. Experimental design: The ability of XL888 to inhibit growth and to induce apoptosis and tumor regression of vemurafenib-resistant melanoma cell lines was demonstrated in vitro and in vivo ."

       

      "The clinical use of BRAF inhibitors is being hampered by the acquisition of drug resistance. This study demonstrates the potential therapeutic utility of the HSP90 inhibitor (XL888) in 6 different models of vemurafenib resistance. Experimental design: The ability of XL888 to inhibit growth and to induce apoptosis and tumor regression of vemurafenib-resistant melanoma cell lines was demonstrated in vitro and in vivo ."

       

      The heat shock protein-90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms

      1.  ↵* Corresponding Author:
        Keiran S.M. Smalley, Molecular Oncology, The Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, 33612, United States [email protected]

       

      This may be a way to get a complete response, with the addition of a HSP90 inhibitor.

      This Paper is for BRAF positive Melanoma Patients.

       

      Best regards,

       

      Jimmy B

    Viewing 2 reply threads
    • Replies
        • February 22, 2012 at 2:24 pm
        boot2aboot
        Participant

          There is a new phase 1 Raf Inhibitor Trial from Novaritis (LGX818 🙂 for failed Zelboraf users…

          However, Here is the question…doing standard treatment or doing Phase 1 trials…dilemma…

          I was thinking of jumping off Zelboraf which is still working and doing Bristol Meyers Anti PD 1, but wondering if that would just be…stupid.- screwing myself on future trials, taking a risk…

          There is talk of 'pulsing' the zelboraf to see if it would last longer…that is, taking and stopping doses intermittantly…

          Anyway, keep researching Jimmy…we appreciate your efforts…

          boots

          • February 22, 2012 at 2:24 pm
          boot2aboot
          Participant

            There is a new phase 1 Raf Inhibitor Trial from Novaritis (LGX818 🙂 for failed Zelboraf users…

            However, Here is the question…doing standard treatment or doing Phase 1 trials…dilemma…

            I was thinking of jumping off Zelboraf which is still working and doing Bristol Meyers Anti PD 1, but wondering if that would just be…stupid.- screwing myself on future trials, taking a risk…

            There is talk of 'pulsing' the zelboraf to see if it would last longer…that is, taking and stopping doses intermittantly…

            Anyway, keep researching Jimmy…we appreciate your efforts…

            boots

            • February 22, 2012 at 2:24 pm
            boot2aboot
            Participant

              There is a new phase 1 Raf Inhibitor Trial from Novaritis (LGX818 🙂 for failed Zelboraf users…

              However, Here is the question…doing standard treatment or doing Phase 1 trials…dilemma…

              I was thinking of jumping off Zelboraf which is still working and doing Bristol Meyers Anti PD 1, but wondering if that would just be…stupid.- screwing myself on future trials, taking a risk…

              There is talk of 'pulsing' the zelboraf to see if it would last longer…that is, taking and stopping doses intermittantly…

              Anyway, keep researching Jimmy…we appreciate your efforts…

              boots

          Viewing 2 reply threads

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