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The double edge of cancer immunotherapy

Forums General Melanoma Community The double edge of cancer immunotherapy

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      ed williams
      Participant

        Hi Anon, if you would take some time and look up the Dr. being quoted in the article you will find that he has an agenda against Immunotherapy treatments that are working for Melanoma patients. His field of research is stem cell engraftment, not some one that I would want to get an expert opinion from in Immunotherapy side effects. I am sure there are some pretty pissed off chemotherapy companies out there, do to the loss of business from the success of Immunotherapy drugs especially check point blockade(ipi and Pd-1) and targeted therapy drugs. I would read that article and put it in the "hit job" on Immunotherapy section of my favorites. I love it when Anon's post this kind of B.S.

        ed williams
        Participant

          Hi Anon, if you would take some time and look up the Dr. being quoted in the article you will find that he has an agenda against Immunotherapy treatments that are working for Melanoma patients. His field of research is stem cell engraftment, not some one that I would want to get an expert opinion from in Immunotherapy side effects. I am sure there are some pretty pissed off chemotherapy companies out there, do to the loss of business from the success of Immunotherapy drugs especially check point blockade(ipi and Pd-1) and targeted therapy drugs. I would read that article and put it in the "hit job" on Immunotherapy section of my favorites. I love it when Anon's post this kind of B.S.

          ed williams
          Participant

            Hi Anon, if you would take some time and look up the Dr. being quoted in the article you will find that he has an agenda against Immunotherapy treatments that are working for Melanoma patients. His field of research is stem cell engraftment, not some one that I would want to get an expert opinion from in Immunotherapy side effects. I am sure there are some pretty pissed off chemotherapy companies out there, do to the loss of business from the success of Immunotherapy drugs especially check point blockade(ipi and Pd-1) and targeted therapy drugs. I would read that article and put it in the "hit job" on Immunotherapy section of my favorites. I love it when Anon's post this kind of B.S.

              lou2
              Participant

                There are a lot of anonymous posts and I don't think you can expect all people to be able to decipher nefarious intent in published articles.  I think it would be fair to say that many of them have motive.  You probably are mad because you want the "CURE" to be found, and one with no side effects and works for everyone.  Gee, that does sound wonderful.  If only it were true, and true about every medical problem.  But don't take your fear and anxiety out on other patients who are just as scared as you are.

                Recently there was a Science mag sponsored webinar about immune therapy for cancer, and it was clear that it was not perfect.  Clear because they kept repeating that one of the challenges now was to figure out which patient would be helped by this, and which would not.  Does that tell you something?

                I would not want to reduce the hope of anyone with this awful cancer, but some of us do want the whole story before we invest our time, money, and whole heart in something.  Do you read all the published articles on melanoma treatment, does anyone before they start a treatment?  I doubt it.  They go to the places that are recommended on this forum and they trust the doctors to tell them the truth about the pro's and cons of treatment.  Some of us do want to know the cons as well.  In the end we all have to make a choice about what to do, how much we want to know.  If you do not want to know, and assume everyone that does tell you the cons has an ulterior motive, then that is your choice.  It is not everyones.  If they don't want to read posts like this, they can just pass it by.

                lou2
                Participant

                  There are a lot of anonymous posts and I don't think you can expect all people to be able to decipher nefarious intent in published articles.  I think it would be fair to say that many of them have motive.  You probably are mad because you want the "CURE" to be found, and one with no side effects and works for everyone.  Gee, that does sound wonderful.  If only it were true, and true about every medical problem.  But don't take your fear and anxiety out on other patients who are just as scared as you are.

                  Recently there was a Science mag sponsored webinar about immune therapy for cancer, and it was clear that it was not perfect.  Clear because they kept repeating that one of the challenges now was to figure out which patient would be helped by this, and which would not.  Does that tell you something?

                  I would not want to reduce the hope of anyone with this awful cancer, but some of us do want the whole story before we invest our time, money, and whole heart in something.  Do you read all the published articles on melanoma treatment, does anyone before they start a treatment?  I doubt it.  They go to the places that are recommended on this forum and they trust the doctors to tell them the truth about the pro's and cons of treatment.  Some of us do want to know the cons as well.  In the end we all have to make a choice about what to do, how much we want to know.  If you do not want to know, and assume everyone that does tell you the cons has an ulterior motive, then that is your choice.  It is not everyones.  If they don't want to read posts like this, they can just pass it by.

                  lou2
                  Participant

                    There are a lot of anonymous posts and I don't think you can expect all people to be able to decipher nefarious intent in published articles.  I think it would be fair to say that many of them have motive.  You probably are mad because you want the "CURE" to be found, and one with no side effects and works for everyone.  Gee, that does sound wonderful.  If only it were true, and true about every medical problem.  But don't take your fear and anxiety out on other patients who are just as scared as you are.

                    Recently there was a Science mag sponsored webinar about immune therapy for cancer, and it was clear that it was not perfect.  Clear because they kept repeating that one of the challenges now was to figure out which patient would be helped by this, and which would not.  Does that tell you something?

                    I would not want to reduce the hope of anyone with this awful cancer, but some of us do want the whole story before we invest our time, money, and whole heart in something.  Do you read all the published articles on melanoma treatment, does anyone before they start a treatment?  I doubt it.  They go to the places that are recommended on this forum and they trust the doctors to tell them the truth about the pro's and cons of treatment.  Some of us do want to know the cons as well.  In the end we all have to make a choice about what to do, how much we want to know.  If you do not want to know, and assume everyone that does tell you the cons has an ulterior motive, then that is your choice.  It is not everyones.  If they don't want to read posts like this, they can just pass it by.

                    lou2
                    Participant

                      I am really bothered that you say this author is biased because of his field of study.  Apparently you did not read the article I posted.  Here is a quote "Concerted research efforts to understand the mechanisms of immunotherapy-triggered responses are crucial for developing better treatments."

                      Obviously we need to identify and deal with side effects of cancer therapies.  The article points out that almost known of the trials have as part of the research the undesirable side effects.  Wouldn't you want that to be handled better?

                      I know a woman who had a solid abdominal cancer, not melanoma, that was treated with a cocktail of cancer drugs.  It was apparently cured, but she was left with peripheral neuropathy and other side effects.  Because of the neuropathy, she has no feeling in her toes and it affects her balance.  So, one day this caused her to fall and break bones in her hand and wrist.  Certainly all of us would want to avoid this kind of result from cancer treatment, wouldn't we?

                      lou2
                      Participant

                        I am really bothered that you say this author is biased because of his field of study.  Apparently you did not read the article I posted.  Here is a quote "Concerted research efforts to understand the mechanisms of immunotherapy-triggered responses are crucial for developing better treatments."

                        Obviously we need to identify and deal with side effects of cancer therapies.  The article points out that almost known of the trials have as part of the research the undesirable side effects.  Wouldn't you want that to be handled better?

                        I know a woman who had a solid abdominal cancer, not melanoma, that was treated with a cocktail of cancer drugs.  It was apparently cured, but she was left with peripheral neuropathy and other side effects.  Because of the neuropathy, she has no feeling in her toes and it affects her balance.  So, one day this caused her to fall and break bones in her hand and wrist.  Certainly all of us would want to avoid this kind of result from cancer treatment, wouldn't we?

                        lou2
                        Participant

                          I am really bothered that you say this author is biased because of his field of study.  Apparently you did not read the article I posted.  Here is a quote "Concerted research efforts to understand the mechanisms of immunotherapy-triggered responses are crucial for developing better treatments."

                          Obviously we need to identify and deal with side effects of cancer therapies.  The article points out that almost known of the trials have as part of the research the undesirable side effects.  Wouldn't you want that to be handled better?

                          I know a woman who had a solid abdominal cancer, not melanoma, that was treated with a cocktail of cancer drugs.  It was apparently cured, but she was left with peripheral neuropathy and other side effects.  Because of the neuropathy, she has no feeling in her toes and it affects her balance.  So, one day this caused her to fall and break bones in her hand and wrist.  Certainly all of us would want to avoid this kind of result from cancer treatment, wouldn't we?

                        ed williams
                        Participant

                          Hi Lou2, while I read the article and came across the name Dr.William J Murphy a little bell went off in my radiated brain. So I went back and read an article that was posted on the forum before x-mas  https://www.nytimes.com/2016/12/03/health/immunotherapy-cancer.html?_r=0  if you go to the 14th paragraph again Dr. William J Murphy is being quoted about the risk of check point inhibotors ( CTLA-4 and Pd-1) drugs and the need to slow down do to IRAE being not studied enough etc etc. So I looked the Dr. up and found that he is very respected in the medical field and is a teacher and does research in various types of Cancer including Melanoma. He is big into NK (Natural Killer) cells and stem cell research. When Anon's publish articles that in my opinion are trying to create a fear of using Immunotherapy drugs and use experts, but not experts like Dr.Weber or Dr.Omid Hamid or Dr.Wolchok, or Dr.James Allison, or Dr.Pam Sharma, or Dr. Michael Postow, or Dr.Jason Luke, but some one that is an expert in using vaccines and Nk cells and stem cells none of which are front line Melanoma therapies at present. Maybe if there had been only one such article against the new drugs in Immunotherpy but Dr. Murphy is being quoted in two separate negative articles. I don't have a problem with Anon's who are looking for help and advice but when they come to our forum and post articles trying to create fear then I do speak up and will continue to speak up. I have some more stuff about Dr. Murphy, Lou2, if you are interested?  https://www.youtube.com/watch?v=spuJ0c6DuIU Have a nice day Lou2!!! Ed

                            lou2
                            Participant

                              Sorry, I know you don't want to hear anything against immunotherapy, but not everyone feels this way.  If you want to ignore anyone who wishes for side effects to be part of research and hopefully reduced, then do that.  You have used someone's background to tarnish any effort to improve treatment.  As far as I know, there is no cancer treatment without side effects, some worse than others.  But patients should be told what they are, and improvements should be made.  Unless you think ignorance is preferable.  Choose it for yourself, not others.  Ordinarily I would not speak this way to another sick person, but you were rude and unfair, attacking me for posting what some people would think is common sense about medical treatments.  Maybe this is not a friendly place for sick people and I should leave.

                              jennunicorn
                              Participant

                                Side effects will always be around, there will never be a treatment for any ailment without side effects. Of course we'd like those side effects to be less dangerous and not as prevelent, perhaps as immunotherapy is fine tuned more in the future that will be the case. The one thing we have to remember about anytime a new drug is developed, the scientists do not know what side effects will occur in patients. They do the trials and get some data as far as what side effects pop up and which are more common. But, even after a drug is FDA approved, the whole range of possible side effects is still unknown. New patients will report new and different side effects and doctors will continue to learn about them and how to treat them or even how to prevent them from happening. The best thing we can do as patients is find a top notch specialist who is familiar or even active in melanoma research so that we know we're in the best hands when/if a serious side effect comes up. 

                                Some of us might be a little sensitive to doctors who are speaking about immunotherapy as if its side effects outweigh the benefit of how well it can kill cancer. The side effects are treatable. Some may have to deal with taking a hormone replacement the rest of their life because their pituitary was damaged on immunotherapy… but they have a chance at the rest of their life! That's the best part. I think any of us would trade a few new daily medications over cancer any day. Before immunotherapy, late stage melanoma patients were kind of sh*t outta luck… they hoped the old treatments would work, but most of the time they didn't. It was almost always a death sentence at stage 4. Now, thanks to these awesome new drugs, that may or may not give us some crappy side effects, we have a serious chance at living. 

                                Hoping nothing but the best for you in whatever stage of treatment you're at. We all deserve to beat this nasty thing and live long lives… even if we get a little crabby sometimes ๐Ÿ™‚ 

                                cancersnewnormal
                                Participant

                                  Yes, yes, and another yes to this response directly above. : )  Not sure who this particular "anon" is, but you swiped the words right out of my head. 

                                  cancersnewnormal
                                  Participant

                                    Yes, yes, and another yes to this response directly above. : )  Not sure who this particular "anon" is, but you swiped the words right out of my head. 

                                    cancersnewnormal
                                    Participant

                                      Yes, yes, and another yes to this response directly above. : )  Not sure who this particular "anon" is, but you swiped the words right out of my head. 

                                      jennunicorn
                                      Participant

                                        Side effects will always be around, there will never be a treatment for any ailment without side effects. Of course we'd like those side effects to be less dangerous and not as prevelent, perhaps as immunotherapy is fine tuned more in the future that will be the case. The one thing we have to remember about anytime a new drug is developed, the scientists do not know what side effects will occur in patients. They do the trials and get some data as far as what side effects pop up and which are more common. But, even after a drug is FDA approved, the whole range of possible side effects is still unknown. New patients will report new and different side effects and doctors will continue to learn about them and how to treat them or even how to prevent them from happening. The best thing we can do as patients is find a top notch specialist who is familiar or even active in melanoma research so that we know we're in the best hands when/if a serious side effect comes up. 

                                        Some of us might be a little sensitive to doctors who are speaking about immunotherapy as if its side effects outweigh the benefit of how well it can kill cancer. The side effects are treatable. Some may have to deal with taking a hormone replacement the rest of their life because their pituitary was damaged on immunotherapy… but they have a chance at the rest of their life! That's the best part. I think any of us would trade a few new daily medications over cancer any day. Before immunotherapy, late stage melanoma patients were kind of sh*t outta luck… they hoped the old treatments would work, but most of the time they didn't. It was almost always a death sentence at stage 4. Now, thanks to these awesome new drugs, that may or may not give us some crappy side effects, we have a serious chance at living. 

                                        Hoping nothing but the best for you in whatever stage of treatment you're at. We all deserve to beat this nasty thing and live long lives… even if we get a little crabby sometimes ๐Ÿ™‚ 

                                        jennunicorn
                                        Participant

                                          Side effects will always be around, there will never be a treatment for any ailment without side effects. Of course we'd like those side effects to be less dangerous and not as prevelent, perhaps as immunotherapy is fine tuned more in the future that will be the case. The one thing we have to remember about anytime a new drug is developed, the scientists do not know what side effects will occur in patients. They do the trials and get some data as far as what side effects pop up and which are more common. But, even after a drug is FDA approved, the whole range of possible side effects is still unknown. New patients will report new and different side effects and doctors will continue to learn about them and how to treat them or even how to prevent them from happening. The best thing we can do as patients is find a top notch specialist who is familiar or even active in melanoma research so that we know we're in the best hands when/if a serious side effect comes up. 

                                          Some of us might be a little sensitive to doctors who are speaking about immunotherapy as if its side effects outweigh the benefit of how well it can kill cancer. The side effects are treatable. Some may have to deal with taking a hormone replacement the rest of their life because their pituitary was damaged on immunotherapy… but they have a chance at the rest of their life! That's the best part. I think any of us would trade a few new daily medications over cancer any day. Before immunotherapy, late stage melanoma patients were kind of sh*t outta luck… they hoped the old treatments would work, but most of the time they didn't. It was almost always a death sentence at stage 4. Now, thanks to these awesome new drugs, that may or may not give us some crappy side effects, we have a serious chance at living. 

                                          Hoping nothing but the best for you in whatever stage of treatment you're at. We all deserve to beat this nasty thing and live long lives… even if we get a little crabby sometimes ๐Ÿ™‚ 

                                          lou2
                                          Participant

                                            Sorry, I know you don't want to hear anything against immunotherapy, but not everyone feels this way.  If you want to ignore anyone who wishes for side effects to be part of research and hopefully reduced, then do that.  You have used someone's background to tarnish any effort to improve treatment.  As far as I know, there is no cancer treatment without side effects, some worse than others.  But patients should be told what they are, and improvements should be made.  Unless you think ignorance is preferable.  Choose it for yourself, not others.  Ordinarily I would not speak this way to another sick person, but you were rude and unfair, attacking me for posting what some people would think is common sense about medical treatments.  Maybe this is not a friendly place for sick people and I should leave.

                                            lou2
                                            Participant

                                              Sorry, I know you don't want to hear anything against immunotherapy, but not everyone feels this way.  If you want to ignore anyone who wishes for side effects to be part of research and hopefully reduced, then do that.  You have used someone's background to tarnish any effort to improve treatment.  As far as I know, there is no cancer treatment without side effects, some worse than others.  But patients should be told what they are, and improvements should be made.  Unless you think ignorance is preferable.  Choose it for yourself, not others.  Ordinarily I would not speak this way to another sick person, but you were rude and unfair, attacking me for posting what some people would think is common sense about medical treatments.  Maybe this is not a friendly place for sick people and I should leave.

                                            ed williams
                                            Participant

                                              Hi Lou2, while I read the article and came across the name Dr.William J Murphy a little bell went off in my radiated brain. So I went back and read an article that was posted on the forum before x-mas  https://www.nytimes.com/2016/12/03/health/immunotherapy-cancer.html?_r=0  if you go to the 14th paragraph again Dr. William J Murphy is being quoted about the risk of check point inhibotors ( CTLA-4 and Pd-1) drugs and the need to slow down do to IRAE being not studied enough etc etc. So I looked the Dr. up and found that he is very respected in the medical field and is a teacher and does research in various types of Cancer including Melanoma. He is big into NK (Natural Killer) cells and stem cell research. When Anon's publish articles that in my opinion are trying to create a fear of using Immunotherapy drugs and use experts, but not experts like Dr.Weber or Dr.Omid Hamid or Dr.Wolchok, or Dr.James Allison, or Dr.Pam Sharma, or Dr. Michael Postow, or Dr.Jason Luke, but some one that is an expert in using vaccines and Nk cells and stem cells none of which are front line Melanoma therapies at present. Maybe if there had been only one such article against the new drugs in Immunotherpy but Dr. Murphy is being quoted in two separate negative articles. I don't have a problem with Anon's who are looking for help and advice but when they come to our forum and post articles trying to create fear then I do speak up and will continue to speak up. I have some more stuff about Dr. Murphy, Lou2, if you are interested?  https://www.youtube.com/watch?v=spuJ0c6DuIU Have a nice day Lou2!!! Ed

                                              ed williams
                                              Participant

                                                Hi Lou2, while I read the article and came across the name Dr.William J Murphy a little bell went off in my radiated brain. So I went back and read an article that was posted on the forum before x-mas  https://www.nytimes.com/2016/12/03/health/immunotherapy-cancer.html?_r=0  if you go to the 14th paragraph again Dr. William J Murphy is being quoted about the risk of check point inhibotors ( CTLA-4 and Pd-1) drugs and the need to slow down do to IRAE being not studied enough etc etc. So I looked the Dr. up and found that he is very respected in the medical field and is a teacher and does research in various types of Cancer including Melanoma. He is big into NK (Natural Killer) cells and stem cell research. When Anon's publish articles that in my opinion are trying to create a fear of using Immunotherapy drugs and use experts, but not experts like Dr.Weber or Dr.Omid Hamid or Dr.Wolchok, or Dr.James Allison, or Dr.Pam Sharma, or Dr. Michael Postow, or Dr.Jason Luke, but some one that is an expert in using vaccines and Nk cells and stem cells none of which are front line Melanoma therapies at present. Maybe if there had been only one such article against the new drugs in Immunotherpy but Dr. Murphy is being quoted in two separate negative articles. I don't have a problem with Anon's who are looking for help and advice but when they come to our forum and post articles trying to create fear then I do speak up and will continue to speak up. I have some more stuff about Dr. Murphy, Lou2, if you are interested?  https://www.youtube.com/watch?v=spuJ0c6DuIU Have a nice day Lou2!!! Ed

                                                blessd4x
                                                Participant

                                                  I dont think the original Anon was trying to spark controversy over the article and its legitamacy or how accurate it is.  We Anon's for the greater part are finding our way here out of fear and desperation.  We do not know the in's and out's, whats accurate or not.  Sometimes we post things just to get clarification but not to piss anyone off.  I believe this is a place of support and when we first come here we are naive and need some of you experts to take our hand and guide us.  But if were here and posting its because we are touched by this horrific disease, please dont condemn us or belittle us by our lack of education thus far.  We're reaching out.  Please be kind.

                                                  blessd4x
                                                  Participant

                                                    I dont think the original Anon was trying to spark controversy over the article and its legitamacy or how accurate it is.  We Anon's for the greater part are finding our way here out of fear and desperation.  We do not know the in's and out's, whats accurate or not.  Sometimes we post things just to get clarification but not to piss anyone off.  I believe this is a place of support and when we first come here we are naive and need some of you experts to take our hand and guide us.  But if were here and posting its because we are touched by this horrific disease, please dont condemn us or belittle us by our lack of education thus far.  We're reaching out.  Please be kind.

                                                    blessd4x
                                                    Participant

                                                      I dont think the original Anon was trying to spark controversy over the article and its legitamacy or how accurate it is.  We Anon's for the greater part are finding our way here out of fear and desperation.  We do not know the in's and out's, whats accurate or not.  Sometimes we post things just to get clarification but not to piss anyone off.  I believe this is a place of support and when we first come here we are naive and need some of you experts to take our hand and guide us.  But if were here and posting its because we are touched by this horrific disease, please dont condemn us or belittle us by our lack of education thus far.  We're reaching out.  Please be kind.

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