temozolmide
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temozolmide

› Forums › General Melanoma Community › temozolmide

  • Post
    • September 1, 2014 at 6:58 pm
    starletwoman2007
    Participant
    Can anyone tell me if they have taken temozolmide and whether it has been successful
Viewing 8 reply threads
  • Replies
      • September 2, 2014 at 11:17 am
      Cooper
      Participant

      I found out it is the same as dacarbazine and response is low, like 10%.  They could show me any studies with it either.  I chose to not take it.

      • September 2, 2014 at 11:17 am
      Cooper
      Participant

      I found out it is the same as dacarbazine and response is low, like 10%.  They could show me any studies with it either.  I chose to not take it.

      • September 2, 2014 at 11:17 am
      Cooper
      Participant

      I found out it is the same as dacarbazine and response is low, like 10%.  They could show me any studies with it either.  I chose to not take it.

        • September 2, 2014 at 4:55 pm
        RJoeyB
        Participant

        I haven't used temozolomide (a.k.a.).  However, for clarification, temozolomide and dacarbazine are actually different chemotherapies, both in a class of drugs known as "alkylating agents", but chemicallty different.  But yes, both have a low response rate for melanoma.  You'll also see temozolomide used in combination with other agents for biochemotherapy ("biochemo") regimens for melanoma, typically along with interleukin-2 (IL-2), interferon-alpha, and other combinations of "traditional" chemotherapy drugs — I've heard of various combinations that include two or three of temozolomide, cisplatin, carboplatin, dacarbazine, and vinblastine, among others.

         

        • September 2, 2014 at 4:56 pm
        RJoeyB
        Participant

        …a.k.a. Temodar…,

        accidentally deleted that.

        • September 2, 2014 at 4:56 pm
        RJoeyB
        Participant

        …a.k.a. Temodar…,

        accidentally deleted that.

        • September 2, 2014 at 4:56 pm
        RJoeyB
        Participant

        …a.k.a. Temodar…,

        accidentally deleted that.

        • September 2, 2014 at 4:55 pm
        RJoeyB
        Participant

        I haven't used temozolomide (a.k.a.).  However, for clarification, temozolomide and dacarbazine are actually different chemotherapies, both in a class of drugs known as "alkylating agents", but chemicallty different.  But yes, both have a low response rate for melanoma.  You'll also see temozolomide used in combination with other agents for biochemotherapy ("biochemo") regimens for melanoma, typically along with interleukin-2 (IL-2), interferon-alpha, and other combinations of "traditional" chemotherapy drugs — I've heard of various combinations that include two or three of temozolomide, cisplatin, carboplatin, dacarbazine, and vinblastine, among others.

         

        • September 2, 2014 at 4:55 pm
        RJoeyB
        Participant

        I haven't used temozolomide (a.k.a.).  However, for clarification, temozolomide and dacarbazine are actually different chemotherapies, both in a class of drugs known as "alkylating agents", but chemicallty different.  But yes, both have a low response rate for melanoma.  You'll also see temozolomide used in combination with other agents for biochemotherapy ("biochemo") regimens for melanoma, typically along with interleukin-2 (IL-2), interferon-alpha, and other combinations of "traditional" chemotherapy drugs — I've heard of various combinations that include two or three of temozolomide, cisplatin, carboplatin, dacarbazine, and vinblastine, among others.

         

      • September 2, 2014 at 7:53 pm
      Tim–MRF
      Guest

      Temozolomide does not generate large response rates in melanoma, but that is not to say it has no role at all. Sometimes it can knock tumors back temporarily and allow time for other drugs to kick in. I have heard of it being used in patients with brain mets so they would qualify for clinical trials.

      I also spoke with a Stage IV patient with autoimmune disease and no BRAF mutation. The first disqualified them from immunotherapies and the second from BRAF therapies. Chemo was the only option.

      And some small group of people have good responses.

      The decision about taking this chemotherapy should be part of a larger conversation. Certainly better drugs exist now for first-line therapy under normal circumstances.  

      Hope this helps.

      Tim–MRF

       

        • September 2, 2014 at 8:13 pm
        RJoeyB
        Participant

        Great points Tim.  I also think about the scenario right now where there are people waiting for the approval of pembrolizumab and where temozolomide (or other chemotherapy drugs) might be a good "bridge" option to control or reduce tumor burden for even a couple of months while waiting for the approval and then availability.  As you said, part of a larger conversation and plan.  Especially with all of the changes to melanoma treatment and management these past few years, the role of timing is often underestimated and difficult to manage — I've been playing the timing game for 4 years now and we threw the roadmap away a long time ago.

        Joe

         

        • September 2, 2014 at 8:38 pm
        Cooper
        Participant

        However, there isn't any scientific evidence that it works.  There needs to be a trial to see if it does. It is super expensive too!

        • September 2, 2014 at 8:38 pm
        Cooper
        Participant

        However, there isn't any scientific evidence that it works.  There needs to be a trial to see if it does. It is super expensive too!

        • September 2, 2014 at 8:38 pm
        Cooper
        Participant

        However, there isn't any scientific evidence that it works.  There needs to be a trial to see if it does. It is super expensive too!

        • September 2, 2014 at 8:13 pm
        RJoeyB
        Participant

        Great points Tim.  I also think about the scenario right now where there are people waiting for the approval of pembrolizumab and where temozolomide (or other chemotherapy drugs) might be a good "bridge" option to control or reduce tumor burden for even a couple of months while waiting for the approval and then availability.  As you said, part of a larger conversation and plan.  Especially with all of the changes to melanoma treatment and management these past few years, the role of timing is often underestimated and difficult to manage — I've been playing the timing game for 4 years now and we threw the roadmap away a long time ago.

        Joe

         

        • September 2, 2014 at 8:13 pm
        RJoeyB
        Participant

        Great points Tim.  I also think about the scenario right now where there are people waiting for the approval of pembrolizumab and where temozolomide (or other chemotherapy drugs) might be a good "bridge" option to control or reduce tumor burden for even a couple of months while waiting for the approval and then availability.  As you said, part of a larger conversation and plan.  Especially with all of the changes to melanoma treatment and management these past few years, the role of timing is often underestimated and difficult to manage — I've been playing the timing game for 4 years now and we threw the roadmap away a long time ago.

        Joe

         

      • September 2, 2014 at 7:53 pm
      Tim–MRF
      Guest

      Temozolomide does not generate large response rates in melanoma, but that is not to say it has no role at all. Sometimes it can knock tumors back temporarily and allow time for other drugs to kick in. I have heard of it being used in patients with brain mets so they would qualify for clinical trials.

      I also spoke with a Stage IV patient with autoimmune disease and no BRAF mutation. The first disqualified them from immunotherapies and the second from BRAF therapies. Chemo was the only option.

      And some small group of people have good responses.

      The decision about taking this chemotherapy should be part of a larger conversation. Certainly better drugs exist now for first-line therapy under normal circumstances.  

      Hope this helps.

      Tim–MRF

       

      • September 2, 2014 at 7:53 pm
      Tim–MRF
      Guest

      Temozolomide does not generate large response rates in melanoma, but that is not to say it has no role at all. Sometimes it can knock tumors back temporarily and allow time for other drugs to kick in. I have heard of it being used in patients with brain mets so they would qualify for clinical trials.

      I also spoke with a Stage IV patient with autoimmune disease and no BRAF mutation. The first disqualified them from immunotherapies and the second from BRAF therapies. Chemo was the only option.

      And some small group of people have good responses.

      The decision about taking this chemotherapy should be part of a larger conversation. Certainly better drugs exist now for first-line therapy under normal circumstances.  

      Hope this helps.

      Tim–MRF

       

      • September 4, 2014 at 1:02 pm
      hannahcopeland1
      Participant

      i took 4 rounds of temodar this summer after WBR and during ipi infusions. i have an almost incurable brain disease called lepotmeningeal, but it has almost dissappeared! i dont know if it is because of the combination or one of them individually, but i think it helped. 

       

      • September 4, 2014 at 1:02 pm
      hannahcopeland1
      Participant

      i took 4 rounds of temodar this summer after WBR and during ipi infusions. i have an almost incurable brain disease called lepotmeningeal, but it has almost dissappeared! i dont know if it is because of the combination or one of them individually, but i think it helped. 

       

      • September 4, 2014 at 1:02 pm
      hannahcopeland1
      Participant

      i took 4 rounds of temodar this summer after WBR and during ipi infusions. i have an almost incurable brain disease called lepotmeningeal, but it has almost dissappeared! i dont know if it is because of the combination or one of them individually, but i think it helped. 

       

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