Stopping the Merck pd1 trial

Forgive me for not answering you question as I've only just entered the Nivo vs. Ipi trail from Bristol Meyers Squibb, yet you are NED, rihgt?  And when you entered you were what stage/condition? 

I'm curious as the recent trial indicated Pembro beat Ipi hands down and I'm wonding how Pembro worked for you in case I'm on the Nivo (PD-1) leg of this trial or if I'm not and on Ipi (CTLA-4) leg.  Curious… 

Forgive me for not answering you question as I've only just entered the Nivo vs. Ipi trail from Bristol Meyers Squibb, yet you are NED, rihgt?  And when you entered you were what stage/condition? 

I'm curious as the recent trial indicated Pembro beat Ipi hands down and I'm wonding how Pembro worked for you in case I'm on the Nivo (PD-1) leg of this trial or if I'm not and on Ipi (CTLA-4) leg.  Curious… 

Forgive me for not answering you question as I've only just entered the Nivo vs. Ipi trail from Bristol Meyers Squibb, yet you are NED, rihgt?  And when you entered you were what stage/condition? 

I'm curious as the recent trial indicated Pembro beat Ipi hands down and I'm wonding how Pembro worked for you in case I'm on the Nivo (PD-1) leg of this trial or if I'm not and on Ipi (CTLA-4) leg.  Curious… 

Those are great questions and I hope someone can answer them but we may be anxiously awaiting you to answer those questions for us.  If you are a 3 year trial participant you are definitely leading the way for many of us anti PD-1 trial participants.  I'm in a IPI/Nivo combo trial that will hit the 2 year mark in August and I'm not being told anything to lead me to believe they intend to keep offering me the drug so I'm assuming I will be entering the observation period as well.  Unfortunately I'm not NED so if they won't allow me to stay on the drug in the trial I'm hoping to continue through my insurance off trial. 

Good luck to you and congrats on 3 years!

Brian

Those are great questions and I hope someone can answer them but we may be anxiously awaiting you to answer those questions for us.  If you are a 3 year trial participant you are definitely leading the way for many of us anti PD-1 trial participants.  I'm in a IPI/Nivo combo trial that will hit the 2 year mark in August and I'm not being told anything to lead me to believe they intend to keep offering me the drug so I'm assuming I will be entering the observation period as well.  Unfortunately I'm not NED so if they won't allow me to stay on the drug in the trial I'm hoping to continue through my insurance off trial. 

Good luck to you and congrats on 3 years!

Brian

Those are great questions and I hope someone can answer them but we may be anxiously awaiting you to answer those questions for us.  If you are a 3 year trial participant you are definitely leading the way for many of us anti PD-1 trial participants.  I'm in a IPI/Nivo combo trial that will hit the 2 year mark in August and I'm not being told anything to lead me to believe they intend to keep offering me the drug so I'm assuming I will be entering the observation period as well.  Unfortunately I'm not NED so if they won't allow me to stay on the drug in the trial I'm hoping to continue through my insurance off trial. 

Good luck to you and congrats on 3 years!

Brian

Those are great questions and I hope someone can answer them but we may be anxiously awaiting you to answer those questions for us.  If you are a 3 year trial participant you are definitely leading the way for many of us anti PD-1 trial participants.  I'm in a IPI/Nivo combo trial that will hit the 2 year mark in August and I'm not being told anything to lead me to believe they intend to keep offering me the drug so I'm assuming I will be entering the observation period as well.  Unfortunately I'm not NED so if they won't allow me to stay on the drug in the trial I'm hoping to continue through my insurance off trial. 

Good luck to you and congrats on 3 years!

Brian

Those are great questions and I hope someone can answer them but we may be anxiously awaiting you to answer those questions for us.  If you are a 3 year trial participant you are definitely leading the way for many of us anti PD-1 trial participants.  I'm in a IPI/Nivo combo trial that will hit the 2 year mark in August and I'm not being told anything to lead me to believe they intend to keep offering me the drug so I'm assuming I will be entering the observation period as well.  Unfortunately I'm not NED so if they won't allow me to stay on the drug in the trial I'm hoping to continue through my insurance off trial. 

Good luck to you and congrats on 3 years!

Brian

Those are great questions and I hope someone can answer them but we may be anxiously awaiting you to answer those questions for us.  If you are a 3 year trial participant you are definitely leading the way for many of us anti PD-1 trial participants.  I'm in a IPI/Nivo combo trial that will hit the 2 year mark in August and I'm not being told anything to lead me to believe they intend to keep offering me the drug so I'm assuming I will be entering the observation period as well.  Unfortunately I'm not NED so if they won't allow me to stay on the drug in the trial I'm hoping to continue through my insurance off trial. 

Good luck to you and congrats on 3 years!

Brian

Brian is right…we are still waiting on ratties…like all of you…and me…to tell the tale.  I cannot say what the results for all of us will be.  Generally speaking…anti-PD1 patients have greater response rates than ipi patients.

http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/04/ipi-vs-nivo-trial-as-adjuvant-for-stage.html

Though the blog post above is specifically about NED patients in both of the studies….but it is still the gist of research data for unresected patients as well.  But…duration of effect?  Anti-PD1 is still too new to know…

But, when you're looking at ipi, it is still pretty good:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/03/ipi-for-melanomathe-data-keeps-pouring.html

On the good side for all of us….more and more researchers feel that it is not necessary to take whatever med you respond to forever.  Durable responses are showing up with BRAFi after patients STOP the med: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/04/brafi-better-when-combined-with-or.html 

Weber has long contended that folks that respond don't need to take anti-PD1 forever.  Of course…the exact amount of time we DO need to take it remains unconfirmed.  For my part, with my ratties….http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/03/one-more-tampa-trip-update-on-33.html

I remain:  139 months post melanoma diagnosis
59 months post Stage IV melanoma
53 months NED
51 months post start of nivo/Opdivo trial
21 months post my last infusion

I don't know if any of this helps.  But, I wish you all my best.  C

Brian is right…we are still waiting on ratties…like all of you…and me…to tell the tale.  I cannot say what the results for all of us will be.  Generally speaking…anti-PD1 patients have greater response rates than ipi patients.

http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/04/ipi-vs-nivo-trial-as-adjuvant-for-stage.html

Though the blog post above is specifically about NED patients in both of the studies….but it is still the gist of research data for unresected patients as well.  But…duration of effect?  Anti-PD1 is still too new to know…

But, when you're looking at ipi, it is still pretty good:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/03/ipi-for-melanomathe-data-keeps-pouring.html

On the good side for all of us….more and more researchers feel that it is not necessary to take whatever med you respond to forever.  Durable responses are showing up with BRAFi after patients STOP the med: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/04/brafi-better-when-combined-with-or.html 

Weber has long contended that folks that respond don't need to take anti-PD1 forever.  Of course…the exact amount of time we DO need to take it remains unconfirmed.  For my part, with my ratties….http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/03/one-more-tampa-trip-update-on-33.html

I remain:  139 months post melanoma diagnosis
59 months post Stage IV melanoma
53 months NED
51 months post start of nivo/Opdivo trial
21 months post my last infusion

I don't know if any of this helps.  But, I wish you all my best.  C

Brian is right…we are still waiting on ratties…like all of you…and me…to tell the tale.  I cannot say what the results for all of us will be.  Generally speaking…anti-PD1 patients have greater response rates than ipi patients.

http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/04/ipi-vs-nivo-trial-as-adjuvant-for-stage.html

Though the blog post above is specifically about NED patients in both of the studies….but it is still the gist of research data for unresected patients as well.  But…duration of effect?  Anti-PD1 is still too new to know…

But, when you're looking at ipi, it is still pretty good:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/03/ipi-for-melanomathe-data-keeps-pouring.html

On the good side for all of us….more and more researchers feel that it is not necessary to take whatever med you respond to forever.  Durable responses are showing up with BRAFi after patients STOP the med: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/04/brafi-better-when-combined-with-or.html 

Weber has long contended that folks that respond don't need to take anti-PD1 forever.  Of course…the exact amount of time we DO need to take it remains unconfirmed.  For my part, with my ratties….http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/03/one-more-tampa-trip-update-on-33.html

I remain:  139 months post melanoma diagnosis
59 months post Stage IV melanoma
53 months NED
51 months post start of nivo/Opdivo trial
21 months post my last infusion

I don't know if any of this helps.  But, I wish you all my best.  C

I don't know the answers to your questions either.  But I am also curious to know more.

Like…how many of you out there were on the Merck Pembro trial and decided to come off the trial just for the heck of it and how you guys are doing?  Have any of you relapsed?

I have been on Merck's Pembro trial for 2.5 years so far and the doctors are planning on keeping me on the trial with no end date.  I am on the 10mg dose every 3 weeks for 30 minutes.   I've never been on any other treatments.  To the doctors I am considered a Partial Responder.  But in my mind…I feel like a Full Responder because there really is no evidence anywhere of anything going wrong.

All my best to you, Laurie

I don't know the answers to your questions either.  But I am also curious to know more.

Like…how many of you out there were on the Merck Pembro trial and decided to come off the trial just for the heck of it and how you guys are doing?  Have any of you relapsed?

I have been on Merck's Pembro trial for 2.5 years so far and the doctors are planning on keeping me on the trial with no end date.  I am on the 10mg dose every 3 weeks for 30 minutes.   I've never been on any other treatments.  To the doctors I am considered a Partial Responder.  But in my mind…I feel like a Full Responder because there really is no evidence anywhere of anything going wrong.

All my best to you, Laurie

I don't know the answers to your questions either.  But I am also curious to know more.

Like…how many of you out there were on the Merck Pembro trial and decided to come off the trial just for the heck of it and how you guys are doing?  Have any of you relapsed?

I have been on Merck's Pembro trial for 2.5 years so far and the doctors are planning on keeping me on the trial with no end date.  I am on the 10mg dose every 3 weeks for 30 minutes.   I've never been on any other treatments.  To the doctors I am considered a Partial Responder.  But in my mind…I feel like a Full Responder because there really is no evidence anywhere of anything going wrong.

All my best to you, Laurie